Faster Rate of Initial Fluid Resuscitation in Severe Acute Pancreatitis Diminishes In-Hospital Mortality
Abstract Background/Aims: We evaluated the impact of the initial intravenous fluid resuscitation rate within the first 24 h of presentation to the emergency room on important outcomes in severe acute pancreatitis. Methods: Patients presenting directly with a diagnosis of severe acute pancreatitis we...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2009-01, Vol.9 (6), p.770-776 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| creator | Gardner, Timothy B Vege, Santhi Swaroop Chari, Suresh T Petersen, Bret T Topazian, Mark D Clain, Jonathan E Pearson, Randall K Levy, Michael J Sarr, Michael G |
| description | Abstract Background/Aims: We evaluated the impact of the initial intravenous fluid resuscitation rate within the first 24 h of presentation to the emergency room on important outcomes in severe acute pancreatitis. Methods: Patients presenting directly with a diagnosis of severe acute pancreatitis were identified retrospectively. Patients were divided into two groups — those who received ≥.33% (‘early resuscitation’) and |
| doi_str_mv | 10.1159/000210022 |
| format | Article |
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Methods: Patients presenting directly with a diagnosis of severe acute pancreatitis were identified retrospectively. Patients were divided into two groups — those who received ≥.33% (‘early resuscitation’) and <33% (‘late resuscitation’) of their cumulative 72-hour intravenous fluid volume within the first 24 h of presentation.The primary clinical outcomes were in-hospital mortality, development of persistent organ failure, and duration of hospitalization. Results: 17 patients were identified in the ‘early resuscitation’ group and 28 in the ‘late resuscitation’ group and there were no baseline differences in clinical characteristics between groups. Patients in the ‘late resuscitation’ group experienced greater mortality than those in the ‘early resuscitation’ group (18 vs. 0%,p<0.04) and demonstrated a trend toward greater rates of persistent organ failure (43 vs. 35%, p = 0.31). There was no difference in the total amount of fluid given during the first 72 h. Conclusions: Patients with severe acute pancreatitis who do not receive at least one third of their initial 72-hour cumulative intravenous fluid volume during the first 24 h are at riskfor greater mortality than those who are initially resuscitated more aggressively.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1159/000210022</identifier><identifier>PMID: 20110744</identifier><language>eng</language><publisher>Basel, Switzerland: Elsevier B.V</publisher><subject>Acute pancreatitis ; Adult ; Aged ; Endocrinology & Metabolism ; Female ; Fluid resuscitation ; Fluid Therapy - methods ; Gastroenterology and Hepatology ; Hospital Mortality ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Original Paper ; Pancreatitis, Acute Necrotizing - mortality ; Pancreatitis, Acute Necrotizing - therapy ; Retrospective Studies</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2009-01, Vol.9 (6), p.770-776</ispartof><rights>IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd.</rights><rights>2009 IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd.</rights><rights>2010 S. Karger AG, Basel and IAP</rights><rights>Copyright 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-38ced351261fd1afff0f1aaea4af4a24080ba6720aba94f288113b3747d9a60e3</citedby><cites>FETCH-LOGICAL-c523t-38ced351261fd1afff0f1aaea4af4a24080ba6720aba94f288113b3747d9a60e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20110744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gardner, Timothy B</creatorcontrib><creatorcontrib>Vege, Santhi Swaroop</creatorcontrib><creatorcontrib>Chari, Suresh T</creatorcontrib><creatorcontrib>Petersen, Bret T</creatorcontrib><creatorcontrib>Topazian, Mark D</creatorcontrib><creatorcontrib>Clain, Jonathan E</creatorcontrib><creatorcontrib>Pearson, Randall K</creatorcontrib><creatorcontrib>Levy, Michael J</creatorcontrib><creatorcontrib>Sarr, Michael G</creatorcontrib><title>Faster Rate of Initial Fluid Resuscitation in Severe Acute Pancreatitis Diminishes In-Hospital Mortality</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Abstract Background/Aims: We evaluated the impact of the initial intravenous fluid resuscitation rate within the first 24 h of presentation to the emergency room on important outcomes in severe acute pancreatitis. Methods: Patients presenting directly with a diagnosis of severe acute pancreatitis were identified retrospectively. Patients were divided into two groups — those who received ≥.33% (‘early resuscitation’) and <33% (‘late resuscitation’) of their cumulative 72-hour intravenous fluid volume within the first 24 h of presentation.The primary clinical outcomes were in-hospital mortality, development of persistent organ failure, and duration of hospitalization. Results: 17 patients were identified in the ‘early resuscitation’ group and 28 in the ‘late resuscitation’ group and there were no baseline differences in clinical characteristics between groups. Patients in the ‘late resuscitation’ group experienced greater mortality than those in the ‘early resuscitation’ group (18 vs. 0%,p<0.04) and demonstrated a trend toward greater rates of persistent organ failure (43 vs. 35%, p = 0.31). There was no difference in the total amount of fluid given during the first 72 h. Conclusions: Patients with severe acute pancreatitis who do not receive at least one third of their initial 72-hour cumulative intravenous fluid volume during the first 24 h are at riskfor greater mortality than those who are initially resuscitated more aggressively.</description><subject>Acute pancreatitis</subject><subject>Adult</subject><subject>Aged</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Fluid resuscitation</subject><subject>Fluid Therapy - methods</subject><subject>Gastroenterology and Hepatology</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Pancreatitis, Acute Necrotizing - mortality</subject><subject>Pancreatitis, Acute Necrotizing - therapy</subject><subject>Retrospective Studies</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptktFrFDEQxoNYbG198F0k-CI-rGaS7O3uS6FUry1ULK0-h7nsxKbd25xJtnD_vTmuPaH4ECYwv29m8mUYewviM0DdfRFCSChHvmAHoKWuVAfwcncXap-9TuluQwB0r9i-FACi0fqA3c4xZYr8GjPx4PjF6LPHgc-Hyff8mtKUrM-YfRi5H_kNPVAkfmKngl_haCOVXPaJf_VLP_p0S6nUqM5DWhXZwL-HWILP6yO253BI9OYxHrJf828_T8-ryx9nF6cnl5WtpcqVai31qgY5A9cDOueEA0RCjU6j1KIVC5w1UuACO-1k2wKohWp003c4E6QO2cdt3VUMfyZK2Sx9sjQMOFKYkmmUajsx000hPzwj78IUxzKckU1dIN3UBfq0hWwMKUVyZhX9EuPagDAb883O_MK-fyw4LZbU78gntwvwbgvcY_xN8R_wpFfbNBV_HnwBivc0FkN8JJtNH_x_ux4_U9mh_ITF4Z7WlHZvApOkEeZmsxSbnRBdW-aqtfoL4dSs1A</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Gardner, Timothy B</creator><creator>Vege, Santhi Swaroop</creator><creator>Chari, Suresh T</creator><creator>Petersen, Bret T</creator><creator>Topazian, Mark D</creator><creator>Clain, Jonathan E</creator><creator>Pearson, Randall K</creator><creator>Levy, Michael J</creator><creator>Sarr, Michael G</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Faster Rate of Initial Fluid Resuscitation in Severe Acute Pancreatitis Diminishes In-Hospital Mortality</title><author>Gardner, Timothy B ; Vege, Santhi Swaroop ; Chari, Suresh T ; Petersen, Bret T ; Topazian, Mark D ; Clain, Jonathan E ; Pearson, Randall K ; Levy, Michael J ; Sarr, Michael G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-38ced351261fd1afff0f1aaea4af4a24080ba6720aba94f288113b3747d9a60e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute pancreatitis</topic><topic>Adult</topic><topic>Aged</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Fluid resuscitation</topic><topic>Fluid Therapy - methods</topic><topic>Gastroenterology and Hepatology</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Pancreatitis, Acute Necrotizing - mortality</topic><topic>Pancreatitis, Acute Necrotizing - therapy</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gardner, Timothy B</creatorcontrib><creatorcontrib>Vege, Santhi Swaroop</creatorcontrib><creatorcontrib>Chari, Suresh T</creatorcontrib><creatorcontrib>Petersen, Bret T</creatorcontrib><creatorcontrib>Topazian, Mark D</creatorcontrib><creatorcontrib>Clain, Jonathan E</creatorcontrib><creatorcontrib>Pearson, Randall K</creatorcontrib><creatorcontrib>Levy, Michael J</creatorcontrib><creatorcontrib>Sarr, Michael G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gardner, Timothy B</au><au>Vege, Santhi Swaroop</au><au>Chari, Suresh T</au><au>Petersen, Bret T</au><au>Topazian, Mark D</au><au>Clain, Jonathan E</au><au>Pearson, Randall K</au><au>Levy, Michael J</au><au>Sarr, Michael G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Faster Rate of Initial Fluid Resuscitation in Severe Acute Pancreatitis Diminishes In-Hospital Mortality</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>9</volume><issue>6</issue><spage>770</spage><epage>776</epage><pages>770-776</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Abstract Background/Aims: We evaluated the impact of the initial intravenous fluid resuscitation rate within the first 24 h of presentation to the emergency room on important outcomes in severe acute pancreatitis. Methods: Patients presenting directly with a diagnosis of severe acute pancreatitis were identified retrospectively. Patients were divided into two groups — those who received ≥.33% (‘early resuscitation’) and <33% (‘late resuscitation’) of their cumulative 72-hour intravenous fluid volume within the first 24 h of presentation.The primary clinical outcomes were in-hospital mortality, development of persistent organ failure, and duration of hospitalization. Results: 17 patients were identified in the ‘early resuscitation’ group and 28 in the ‘late resuscitation’ group and there were no baseline differences in clinical characteristics between groups. Patients in the ‘late resuscitation’ group experienced greater mortality than those in the ‘early resuscitation’ group (18 vs. 0%,p<0.04) and demonstrated a trend toward greater rates of persistent organ failure (43 vs. 35%, p = 0.31). There was no difference in the total amount of fluid given during the first 72 h. Conclusions: Patients with severe acute pancreatitis who do not receive at least one third of their initial 72-hour cumulative intravenous fluid volume during the first 24 h are at riskfor greater mortality than those who are initially resuscitated more aggressively.</abstract><cop>Basel, Switzerland</cop><pub>Elsevier B.V</pub><pmid>20110744</pmid><doi>10.1159/000210022</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2009-01, Vol.9 (6), p.770-776 |
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| language | eng |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Acute pancreatitis Adult Aged Endocrinology & Metabolism Female Fluid resuscitation Fluid Therapy - methods Gastroenterology and Hepatology Hospital Mortality Humans Infusions, Intravenous Male Middle Aged Original Paper Pancreatitis, Acute Necrotizing - mortality Pancreatitis, Acute Necrotizing - therapy Retrospective Studies |
| title | Faster Rate of Initial Fluid Resuscitation in Severe Acute Pancreatitis Diminishes In-Hospital Mortality |
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