IV amantadine improves chorea in Huntington's disease: An acute randomized, controlled study
The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-...
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| Veröffentlicht in: | Neurology 2003-06, Vol.60 (12), p.1995-1997 |
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| container_end_page | 1997 |
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| container_issue | 12 |
| container_start_page | 1995 |
| container_title | Neurology |
| container_volume | 60 |
| creator | LUCETTI, C DEL DOTTO, P GAMBACCINI, G DELL'AGNELLO, G BERNARDINI, S ROSSI, G MURRI, L BONUCCELLI, U |
| description | The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales. |
| doi_str_mv | 10.1212/01.WNL.0000068165.07883.64 |
| format | Article |
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A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/01.WNL.0000068165.07883.64</identifier><identifier>PMID: 12821751</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Administration, Oral ; Aged ; Amantadine - administration & dosage ; Amantadine - therapeutic use ; Biological and medical sciences ; Catecholaminergic system ; Cross-Over Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Drug Administration Schedule ; Excitatory Amino Acid Antagonists - administration & dosage ; Excitatory Amino Acid Antagonists - therapeutic use ; Female ; Glutamic Acid - metabolism ; Humans ; Huntington Disease - drug therapy ; Huntington Disease - physiopathology ; Huntington Disease - psychology ; Infusions, Intravenous ; Male ; Medical sciences ; Middle Aged ; Motor Activity - drug effects ; Neurology ; Neuropharmacology ; Neuropsychological Tests ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Neurology, 2003-06, Vol.60 (12), p.1995-1997</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-dd4f81984a4fab5b86c21b574dc840ec4af00449e1026545f8df79429bf9924a3</citedby><cites>FETCH-LOGICAL-c345t-dd4f81984a4fab5b86c21b574dc840ec4af00449e1026545f8df79429bf9924a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14885980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12821751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LUCETTI, C</creatorcontrib><creatorcontrib>DEL DOTTO, P</creatorcontrib><creatorcontrib>GAMBACCINI, G</creatorcontrib><creatorcontrib>DELL'AGNELLO, G</creatorcontrib><creatorcontrib>BERNARDINI, S</creatorcontrib><creatorcontrib>ROSSI, G</creatorcontrib><creatorcontrib>MURRI, L</creatorcontrib><creatorcontrib>BONUCCELLI, U</creatorcontrib><title>IV amantadine improves chorea in Huntington's disease: An acute randomized, controlled study</title><title>Neurology</title><addtitle>Neurology</addtitle><description>The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Amantadine - administration & dosage</subject><subject>Amantadine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Cross-Over Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Drug Administration Schedule</subject><subject>Excitatory Amino Acid Antagonists - administration & dosage</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>Female</subject><subject>Glutamic Acid - metabolism</subject><subject>Humans</subject><subject>Huntington Disease - drug therapy</subject><subject>Huntington Disease - physiopathology</subject><subject>Huntington Disease - psychology</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Activity - drug effects</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Neuropsychological Tests</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAQx4Mo7vr4ChIE9WJrnm3iTRZfsOjF10EIaR4aaVNtWkE_vV13Yecyh_n9Z4YfAIcY5ZhgcoZw_nw3z9GiCoELnqNSCJoXbANMMSdFVlDysgmmCBGRUVGKCdhJ6QOhcVjKbTDBRBBccjwFr7dPUDc69tqG6GBoPrv22yVo3tvOaRgivBliH-Jb38aTBG1ITid3Di8i1GboHex0tG0Tfp09haaNfdfWtbMw9YP92QNbXtfJ7a_6Lni8unyY3WTz--vb2cU8M5TxPrOWeYGlYJp5XfFKFIbgipfMGsGQM0x7hBiTDiNScMa9sL6UjMjKS0mYprvgeLl3fP5rcKlXTUjG1bWOrh2SKikVElE5gudL0HRtSp3z6rMLje5-FEZq4VYhrEa3au1W_btVBRvDB6srQ9U4u46uZI7A0QrQyejaj2pMSGuOCcGlQPQPCOaC2Q</recordid><startdate>20030624</startdate><enddate>20030624</enddate><creator>LUCETTI, C</creator><creator>DEL DOTTO, P</creator><creator>GAMBACCINI, G</creator><creator>DELL'AGNELLO, G</creator><creator>BERNARDINI, S</creator><creator>ROSSI, G</creator><creator>MURRI, L</creator><creator>BONUCCELLI, U</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030624</creationdate><title>IV amantadine improves chorea in Huntington's disease: An acute randomized, controlled study</title><author>LUCETTI, C ; DEL DOTTO, P ; GAMBACCINI, G ; DELL'AGNELLO, G ; BERNARDINI, S ; ROSSI, G ; MURRI, L ; BONUCCELLI, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-dd4f81984a4fab5b86c21b574dc840ec4af00449e1026545f8df79429bf9924a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Amantadine - administration & dosage</topic><topic>Amantadine - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Cross-Over Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Drug Administration Schedule</topic><topic>Excitatory Amino Acid Antagonists - administration & dosage</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>Female</topic><topic>Glutamic Acid - metabolism</topic><topic>Humans</topic><topic>Huntington Disease - drug therapy</topic><topic>Huntington Disease - physiopathology</topic><topic>Huntington Disease - psychology</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Activity - drug effects</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LUCETTI, C</creatorcontrib><creatorcontrib>DEL DOTTO, P</creatorcontrib><creatorcontrib>GAMBACCINI, G</creatorcontrib><creatorcontrib>DELL'AGNELLO, G</creatorcontrib><creatorcontrib>BERNARDINI, S</creatorcontrib><creatorcontrib>ROSSI, G</creatorcontrib><creatorcontrib>MURRI, L</creatorcontrib><creatorcontrib>BONUCCELLI, U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LUCETTI, C</au><au>DEL DOTTO, P</au><au>GAMBACCINI, G</au><au>DELL'AGNELLO, G</au><au>BERNARDINI, S</au><au>ROSSI, G</au><au>MURRI, L</au><au>BONUCCELLI, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IV amantadine improves chorea in Huntington's disease: An acute randomized, controlled study</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2003-06-24</date><risdate>2003</risdate><volume>60</volume><issue>12</issue><spage>1995</spage><epage>1997</epage><pages>1995-1997</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>The acute antidyskinetic effects of IV amantadine in HD were evaluated. A 2-hour IV infusion of amantadine or placebo was administered to nine patients with HD on two different days in a double-blind, randomized crossover fashion. All patients subsequently received oral amantadine unblinded for a 1-year period. A reduction of dyskinesia scores was reported during both IV and oral amantadine treatment (p < 0.05). No significant changes were observed in neuropsychological tests or psychiatric rating scales.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12821751</pmid><doi>10.1212/01.WNL.0000068165.07883.64</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neurology, 2003-06, Vol.60 (12), p.1995-1997 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Administration, Oral Aged Amantadine - administration & dosage Amantadine - therapeutic use Biological and medical sciences Catecholaminergic system Cross-Over Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Administration Schedule Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - therapeutic use Female Glutamic Acid - metabolism Humans Huntington Disease - drug therapy Huntington Disease - physiopathology Huntington Disease - psychology Infusions, Intravenous Male Medical sciences Middle Aged Motor Activity - drug effects Neurology Neuropharmacology Neuropsychological Tests Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Severity of Illness Index Treatment Outcome |
| title | IV amantadine improves chorea in Huntington's disease: An acute randomized, controlled study |
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