Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis

Summary Objectives The role of calcium phosphate and pyrophosphate crystals in osteoarthritis (OA) is unclear: are they a symptom of the damage that occurs to the joint or a key intermediate in the progression of inflammation and joint damage that occurs in OA? The proinflammatory and catabolic resp...

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Veröffentlicht in:	Osteoarthritis and cartilage 2009-10, Vol.17 (10), p.1333-1340
Hauptverfasser:	Liu, Y.Z, Jackson, A.P, Cosgrove, S.D
Format:	Artikel
Sprache:	eng
Schlagworte:	BCP Biomarkers - metabolism Calcium Phosphates - analysis Calcium Phosphates - chemistry Calcium Phosphates - pharmacology Calcium Pyrophosphate Cartilage, Articular - metabolism Cells, Cultured Chondrocalcinosis - metabolism Chondrocyte Chondrocytes - metabolism CPPD CPPT Crystallization DCPD Dinoprostone - metabolism Humans Matrix Metalloproteinase 13 - metabolism MMP-13 Nitric Oxide - metabolism Osteoarthritis Osteoarthritis, Knee - metabolism PGE 2 Pyrophosphate Rheumatology Synovial Membrane - metabolism Synoviocyte X-Ray Diffraction
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