ATR Kinase Activity Regulates the Intranuclear Translocation of ATR and RPA following Ionizing Radiation

Upon damage of DNA in eukaryotic cells, several repair and checkpoint proteins undergo a dramatic intranuclear relocalization, translocating to nuclear foci thought to represent sites of DNA damage and repair. Examples of such proteins include the checkpoint kinase ATR (ATM and Rad3-related) as well...

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Veröffentlicht in:	Current biology 2003-06, Vol.13 (12), p.1047-1051
Hauptverfasser:	Barr, Sharon M., Leung, Cindy G., Chang, Elbert E., Cimprich, Karlene A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - metabolism Cell Cycle Proteins - radiation effects Cell Line Cell Nucleus - metabolism DNA Damage - physiology DNA Damage - radiation effects DNA Repair - physiology DNA-Binding Proteins - metabolism DNA-Binding Proteins - radiation effects Humans Immunohistochemistry Protein-Serine-Threonine Kinases - metabolism Radiation, Ionizing Replication Protein A
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