Role of HIF-1alpha in skeletal development

Angiogenesis and osteogenesis are tightly coupled during bone development and regeneration. Mesenchymal cells in the developing stroma elicit angiogenic signals to recruit new blood vessels into bone. Reciprocal signals, likely emanating from the incoming vascular endothelium, stimulate mesenchymal...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2010-03, Vol.1192, p.322-326
Hauptverfasser:	Wan, Chao, Shao, Jin, Gilbert, Shawn R, Riddle, Ryan C, Long, Fanxin, Johnson, Randall S, Schipani, Ernestina, Clemens, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones - embryology Bone Development - genetics Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - physiology Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Osteogenesis - genetics Signal Transduction - genetics Signal Transduction - physiology Skull - embryology
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