Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma
Background Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC. Methods E...
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| Veröffentlicht in: | Head & neck 2010-05, Vol.32 (5), p.568-571 |
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| creator | Giovanella, Luca Ceriani, Luca Maffioli, Marco |
| description | Background
Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC.
Methods
Enrolled were 96 patients with DTC. Serum Tg was measured first at 5 minutes, then at 24, 48, 72, 96, and 120 hours after thyroidectomy. The Tg half‐life (Tg[t1/2]) was estimated in a 1‐compartment model. A simplified 2‐point formula (24 and 120 hours) was also used.
Results
The mean Tg(t1/2) was 28.53 to 30.22 hours in 1‐compartment model and 27.39 hours when estimated by a simplified formula. A strong inter‐methods relationship was found (p < .001).
Conclusions
A reliable Tg(t1/2) estimation could be obtained by a simplified formula requiring only 2 postsurgery Tg measurements (24 and 120 hours, respectively). © 2009 Wiley Periodicals, Inc. Head Neck, 2010 |
| doi_str_mv | 10.1002/hed.21214 |
| format | Article |
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Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC.
Methods
Enrolled were 96 patients with DTC. Serum Tg was measured first at 5 minutes, then at 24, 48, 72, 96, and 120 hours after thyroidectomy. The Tg half‐life (Tg[t1/2]) was estimated in a 1‐compartment model. A simplified 2‐point formula (24 and 120 hours) was also used.
Results
The mean Tg(t1/2) was 28.53 to 30.22 hours in 1‐compartment model and 27.39 hours when estimated by a simplified formula. A strong inter‐methods relationship was found (p < .001).
Conclusions
A reliable Tg(t1/2) estimation could be obtained by a simplified formula requiring only 2 postsurgery Tg measurements (24 and 120 hours, respectively). © 2009 Wiley Periodicals, Inc. Head Neck, 2010</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21214</identifier><identifier>PMID: 19672965</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Carcinoma - surgery ; differentiated thyroid carcinoma ; Female ; Half-Life ; Humans ; kinetic ; Male ; Middle Aged ; Postoperative Period ; thyroglobulin ; Thyroglobulin - blood ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Young Adult</subject><ispartof>Head & neck, 2010-05, Vol.32 (5), p.568-571</ispartof><rights>Copyright © 2009 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3624-d806aae8d7f17f03a1b1324543d1898a52a07b8c062aa36cf4652f138d5d50693</citedby><cites>FETCH-LOGICAL-c3624-d806aae8d7f17f03a1b1324543d1898a52a07b8c062aa36cf4652f138d5d50693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21214$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21214$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19672965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giovanella, Luca</creatorcontrib><creatorcontrib>Ceriani, Luca</creatorcontrib><creatorcontrib>Maffioli, Marco</creatorcontrib><title>Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC.
Methods
Enrolled were 96 patients with DTC. Serum Tg was measured first at 5 minutes, then at 24, 48, 72, 96, and 120 hours after thyroidectomy. The Tg half‐life (Tg[t1/2]) was estimated in a 1‐compartment model. A simplified 2‐point formula (24 and 120 hours) was also used.
Results
The mean Tg(t1/2) was 28.53 to 30.22 hours in 1‐compartment model and 27.39 hours when estimated by a simplified formula. A strong inter‐methods relationship was found (p < .001).
Conclusions
A reliable Tg(t1/2) estimation could be obtained by a simplified formula requiring only 2 postsurgery Tg measurements (24 and 120 hours, respectively). © 2009 Wiley Periodicals, Inc. Head Neck, 2010</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma - surgery</subject><subject>differentiated thyroid carcinoma</subject><subject>Female</subject><subject>Half-Life</subject><subject>Humans</subject><subject>kinetic</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Period</subject><subject>thyroglobulin</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Young Adult</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElvFDEQRi0EIgsc-AOobyiHTry7-4iyIgUyh6AcrRq7esakN2y3wvx7OukhN061vXqHj5BPjJ4ySvnZFv0pZ5zJN-SQ0dqUVEjz9rmXohTUyANylNIvSqnQkr8nB6zWhtdaHZLNakg5TXGDcVckjFNX5O0uDpt2WE9t6AsfEowjQoTeYfEYeszBFfNhhBywz6l4Cnk7Y02DcZ4DZPSLI_jCQXShHzr4QN410Cb8uK_H5OfV5f35TXl7d_3t_Ott6YTmsvQV1QBYedMw01ABbM0El0oKz6q6AsWBmnXlqOYAQrtGasUbJiqvvKK6Fsfky-Id4_B7wpRtF5LDtoUehylZI0RVGa7UTJ4spItDShEbO8bQQdxZRu1zrHaO1b7EOrOf99Zp3c3bV3Kf4wycLcBTaHH3f5O9ubz4pyyXj5Ay_nn9gPhotRFG2Ycf11Y9fF9d6YuVZeIvK--SPQ</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Giovanella, Luca</creator><creator>Ceriani, Luca</creator><creator>Maffioli, Marco</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma</title><author>Giovanella, Luca ; Ceriani, Luca ; Maffioli, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3624-d806aae8d7f17f03a1b1324543d1898a52a07b8c062aa36cf4652f138d5d50693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma - surgery</topic><topic>differentiated thyroid carcinoma</topic><topic>Female</topic><topic>Half-Life</topic><topic>Humans</topic><topic>kinetic</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Period</topic><topic>thyroglobulin</topic><topic>Thyroglobulin - blood</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giovanella, Luca</creatorcontrib><creatorcontrib>Ceriani, Luca</creatorcontrib><creatorcontrib>Maffioli, Marco</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giovanella, Luca</au><au>Ceriani, Luca</au><au>Maffioli, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2010-05</date><risdate>2010</risdate><volume>32</volume><issue>5</issue><spage>568</spage><epage>571</epage><pages>568-571</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC.
Methods
Enrolled were 96 patients with DTC. Serum Tg was measured first at 5 minutes, then at 24, 48, 72, 96, and 120 hours after thyroidectomy. The Tg half‐life (Tg[t1/2]) was estimated in a 1‐compartment model. A simplified 2‐point formula (24 and 120 hours) was also used.
Results
The mean Tg(t1/2) was 28.53 to 30.22 hours in 1‐compartment model and 27.39 hours when estimated by a simplified formula. A strong inter‐methods relationship was found (p < .001).
Conclusions
A reliable Tg(t1/2) estimation could be obtained by a simplified formula requiring only 2 postsurgery Tg measurements (24 and 120 hours, respectively). © 2009 Wiley Periodicals, Inc. Head Neck, 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19672965</pmid><doi>10.1002/hed.21214</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Carcinoma - surgery differentiated thyroid carcinoma Female Half-Life Humans kinetic Male Middle Aged Postoperative Period thyroglobulin Thyroglobulin - blood Thyroid Neoplasms - surgery Thyroidectomy Young Adult |
| title | Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma |
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