Comprehensive Evaluation and Medical Management of Infrainguinal Peripheral Artery Disease: “When to Treat, When Not to Treat”
Peripheral artery disease (PAD) is a highly prevalent atherosclerotic syndrome associated with significant morbidity and mortality. PAD is defined by atherosclerotic obstruction of the arteries to the legs that reduce arterial flow during exercise or at rest, and is associated with systemic atherosc...
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| Veröffentlicht in: | Techniques in vascular and interventional radiology 2010-03, Vol.13 (1), p.2-10 |
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| creator | Kiernan, Thomas J., MD Hynes, Brian G., MD Ruggiero, Nicholas J., MD Yan, Bryan P., MD Jaff, Michael R., DO |
| description | Peripheral artery disease (PAD) is a highly prevalent atherosclerotic syndrome associated with significant morbidity and mortality. PAD is defined by atherosclerotic obstruction of the arteries to the legs that reduce arterial flow during exercise or at rest, and is associated with systemic atherosclerosis. The clinical presentation of PAD is quite varied, including patients with atypical leg symptoms, classic intermittent claudication, and critical limb ischemia. Clinical assessment of these patients includes a comprehensive history, physical examination, and noninvasive and invasive vascular studies. The major risk factors for PAD include diabetes mellitus, tobacco abuse, hyperlipidemia, hypertension, and advanced age. Because of the presence of these risk factors, the systemic nature of atherosclerosis, and the high risk of ischemic events, patients with PAD should be candidates for comprehensive secondary prevention strategies, including aggressive glycemic control, all attempts at tobacco cessation, lipid lowering and antihypertensive treatment, antiplatelet therapy, and thorough foot care. This article reviews the comprehensive diagnostic algorithm and medical treatment strategies for patients with infrainguinal PAD. |
| doi_str_mv | 10.1053/j.tvir.2009.10.002 |
| format | Article |
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PAD is defined by atherosclerotic obstruction of the arteries to the legs that reduce arterial flow during exercise or at rest, and is associated with systemic atherosclerosis. The clinical presentation of PAD is quite varied, including patients with atypical leg symptoms, classic intermittent claudication, and critical limb ischemia. Clinical assessment of these patients includes a comprehensive history, physical examination, and noninvasive and invasive vascular studies. The major risk factors for PAD include diabetes mellitus, tobacco abuse, hyperlipidemia, hypertension, and advanced age. Because of the presence of these risk factors, the systemic nature of atherosclerosis, and the high risk of ischemic events, patients with PAD should be candidates for comprehensive secondary prevention strategies, including aggressive glycemic control, all attempts at tobacco cessation, lipid lowering and antihypertensive treatment, antiplatelet therapy, and thorough foot care. 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PAD is defined by atherosclerotic obstruction of the arteries to the legs that reduce arterial flow during exercise or at rest, and is associated with systemic atherosclerosis. The clinical presentation of PAD is quite varied, including patients with atypical leg symptoms, classic intermittent claudication, and critical limb ischemia. Clinical assessment of these patients includes a comprehensive history, physical examination, and noninvasive and invasive vascular studies. The major risk factors for PAD include diabetes mellitus, tobacco abuse, hyperlipidemia, hypertension, and advanced age. Because of the presence of these risk factors, the systemic nature of atherosclerosis, and the high risk of ischemic events, patients with PAD should be candidates for comprehensive secondary prevention strategies, including aggressive glycemic control, all attempts at tobacco cessation, lipid lowering and antihypertensive treatment, antiplatelet therapy, and thorough foot care. 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Hynes, Brian G., MD ; Ruggiero, Nicholas J., MD ; Yan, Bryan P., MD ; Jaff, Michael R., DO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-ca9af2fe1dc2b8dbc051b71497f4b38832e15953648d0c3f9063e9fa406194843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Algorithms</topic><topic>Angiography, Digital Subtraction</topic><topic>Arterial Occlusive Diseases - complications</topic><topic>Arterial Occlusive Diseases - diagnosis</topic><topic>Arterial Occlusive Diseases - therapy</topic><topic>Clinical Protocols</topic><topic>Constriction, Pathologic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>intermittent claudication</topic><topic>Intermittent Claudication - etiology</topic><topic>Intermittent Claudication - therapy</topic><topic>Ischemia - etiology</topic><topic>Ischemia - therapy</topic><topic>Lower Extremity - blood supply</topic><topic>Magnetic Resonance Angiography</topic><topic>Patient Selection</topic><topic>peripheral artery disease</topic><topic>Peripheral Vascular Diseases - complications</topic><topic>Peripheral Vascular Diseases - diagnosis</topic><topic>Peripheral Vascular Diseases - therapy</topic><topic>Predictive Value of Tests</topic><topic>Radiology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Secondary Prevention</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiernan, Thomas J., MD</creatorcontrib><creatorcontrib>Hynes, Brian G., MD</creatorcontrib><creatorcontrib>Ruggiero, Nicholas J., MD</creatorcontrib><creatorcontrib>Yan, Bryan P., MD</creatorcontrib><creatorcontrib>Jaff, Michael R., DO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Techniques in vascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiernan, Thomas J., MD</au><au>Hynes, Brian G., MD</au><au>Ruggiero, Nicholas J., MD</au><au>Yan, Bryan P., MD</au><au>Jaff, Michael R., DO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive Evaluation and Medical Management of Infrainguinal Peripheral Artery Disease: “When to Treat, When Not to Treat”</atitle><jtitle>Techniques in vascular and interventional radiology</jtitle><addtitle>Tech Vasc Interv Radiol</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>13</volume><issue>1</issue><spage>2</spage><epage>10</epage><pages>2-10</pages><issn>1089-2516</issn><eissn>1557-9808</eissn><abstract>Peripheral artery disease (PAD) is a highly prevalent atherosclerotic syndrome associated with significant morbidity and mortality. PAD is defined by atherosclerotic obstruction of the arteries to the legs that reduce arterial flow during exercise or at rest, and is associated with systemic atherosclerosis. The clinical presentation of PAD is quite varied, including patients with atypical leg symptoms, classic intermittent claudication, and critical limb ischemia. Clinical assessment of these patients includes a comprehensive history, physical examination, and noninvasive and invasive vascular studies. The major risk factors for PAD include diabetes mellitus, tobacco abuse, hyperlipidemia, hypertension, and advanced age. Because of the presence of these risk factors, the systemic nature of atherosclerosis, and the high risk of ischemic events, patients with PAD should be candidates for comprehensive secondary prevention strategies, including aggressive glycemic control, all attempts at tobacco cessation, lipid lowering and antihypertensive treatment, antiplatelet therapy, and thorough foot care. 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| subjects | Algorithms Angiography, Digital Subtraction Arterial Occlusive Diseases - complications Arterial Occlusive Diseases - diagnosis Arterial Occlusive Diseases - therapy Clinical Protocols Constriction, Pathologic Hematology, Oncology and Palliative Medicine Humans intermittent claudication Intermittent Claudication - etiology Intermittent Claudication - therapy Ischemia - etiology Ischemia - therapy Lower Extremity - blood supply Magnetic Resonance Angiography Patient Selection peripheral artery disease Peripheral Vascular Diseases - complications Peripheral Vascular Diseases - diagnosis Peripheral Vascular Diseases - therapy Predictive Value of Tests Radiology Risk Assessment Risk Factors Secondary Prevention Tomography, X-Ray Computed Treatment Outcome |
| title | Comprehensive Evaluation and Medical Management of Infrainguinal Peripheral Artery Disease: “When to Treat, When Not to Treat” |
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