GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

The clinical importance of benzodiazepines, barbiturates and general anesthetics, all of which act through the γ-aminobutyric acid (GABA)-A neurotransmitter receptor, is testament to its significance as a CNS drug target. These drugs were all developed before there was any understanding of the diver...

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Veröffentlicht in:	Drug Discovery Today 2003-05, Vol.8 (10), p.445-450
1. Verfasser:	Whiting, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	anaesthetic Animals anxiety benzodiazepine Brain - drug effects Brain - metabolism Central Nervous System - drug effects Central Nervous System - metabolism cognition compound Drug Delivery Systems - methods GABA GABA-A Receptor Agonists GABA-A Receptor Antagonists Humans receptor Receptors, GABA-A - metabolism Technology, Pharmaceutical - methods transgenic
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