General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression

Cyclooxygenase (COX) is a critical enzyme in prostaglandin biosynthesis that modulates a wide range of biological functions, such as pain, fever, and so on. To perform in vivo COX imaging by positron emission tomography (PET), we developed a method to incorporate (11)C radionuclide into various 2-ar...

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Veröffentlicht in:	Chemistry : a European journal 2010-04, Vol.16 (14), p.4250-4258
Hauptverfasser:	Takashima-Hirano, Misato, Shukuri, Miho, Takashima, Tadayuki, Goto, Miki, Wada, Yasuhiro, Watanabe, Yasuyoshi, Onoe, Hirotaka, Doi, Hisashi, Suzuki, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Blood - metabolism Brain - metabolism Carbon Radioisotopes - chemistry Carbon Radioisotopes - metabolism Cyclooxygenase 2 Inhibitors - chemistry Cyclooxygenase 2 Inhibitors - metabolism Esters Inflammation - enzymology Methylation Molecular Structure Positron-Emission Tomography - methods Propionates - chemistry Prostaglandin-Endoperoxide Synthases - chemistry Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
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