Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism

In photoreceptor cells of vertebrates light activates a series of protein-protein interactions resulting in activation of a cGMP-phosphodiesterase (PDE). Interaction between the GTP-bound form of rod G-protein alpha-subunit (alpha t) and PDE inhibitory gamma-subunit (P gamma) is a key event for effe...

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Veröffentlicht in:	The Journal of biological chemistry 1992-12, Vol.267 (35), p.25067-25072
Hauptverfasser:	ARTEMYEV, N. O, RARICK, H. M, MILLS, J. S, SKIBA, N. P, HAMM, H. E
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-cyclic GMP phosphodiesterase 3',5'-Cyclic-GMP Phosphodiesterases - metabolism Amino Acid Sequence Animals Binding Sites Binding, Competitive Biological and medical sciences Cattle Cell Membrane - metabolism Cell physiology Enzyme Activation fluorescence Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism guanine nucleotide-binding protein Guanine Nucleotides - pharmacology interaction Kinetics Macromolecular Substances Molecular and cellular biology Molecular Sequence Data Peptides - chemical synthesis Peptides - pharmacology Photoreceptor Cells - metabolism photoreceptors rods Vision, photoreception
Online-Zugang:	Volltext
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