Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry
Abstract Purpose Erythromycin is successfully used as a gastroduodenal prokinetic agent. Given the limited available treatments for colonic dysmotility, further investigation into erythromycin's effect on colonic motility is warranted. We aimed to study the effect of erythromycin on colonic mot...
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description | Abstract Purpose Erythromycin is successfully used as a gastroduodenal prokinetic agent. Given the limited available treatments for colonic dysmotility, further investigation into erythromycin's effect on colonic motility is warranted. We aimed to study the effect of erythromycin on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods Patients referred for colonic manometry were eligible for enrollment. Fasting motility was recorded for 1 to 2 hours, then erythromycin lactobionate (EL), 3 mg/kg, was administered intravenously, and colonic motility was monitored for 1 to 2 hours after erythromycin. Manometry was then continued per routine. The motility index (MI) of pressure tracings at each pressure transducer was calculated for each patient for a period of 15 and 60 minutes before and after EL infusion. Change in MI was compared by Wilcoxon signed rank test. Results Twenty patients were enrolled. The most common indication was constipation with encopresis. Seventy percent of patients had normal colonic manometry, and 30% of patients demonstrated a neuropathy. Average MI for the 60-minute period before and after EL infusion were 254 ± 74 mm Hg/h and 253 ± 94 mm Hg/h, respectively ( P = .55). Average MI for the 15-minute period before and after EL infusion were 64 ± 23 mm Hg/15 min and 69 ± 32 mm Hg/15 min, respectively ( P = .45). Conclusions Administration of intravenous EL resulted in no changes in colonic MI in pediatric patients referred for colonic manometry. Further studies on potential colokinetic agents are warranted in this population of patients. |
doi_str_mv | 10.1016/j.jpedsurg.2009.07.039 |
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Narasimha ; Croffie, Joseph</creator><creatorcontrib>Dranove, Jason ; Horn, Debra ; Reddy, S. Narasimha ; Croffie, Joseph</creatorcontrib><description>Abstract Purpose Erythromycin is successfully used as a gastroduodenal prokinetic agent. Given the limited available treatments for colonic dysmotility, further investigation into erythromycin's effect on colonic motility is warranted. We aimed to study the effect of erythromycin on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods Patients referred for colonic manometry were eligible for enrollment. Fasting motility was recorded for 1 to 2 hours, then erythromycin lactobionate (EL), 3 mg/kg, was administered intravenously, and colonic motility was monitored for 1 to 2 hours after erythromycin. Manometry was then continued per routine. The motility index (MI) of pressure tracings at each pressure transducer was calculated for each patient for a period of 15 and 60 minutes before and after EL infusion. Change in MI was compared by Wilcoxon signed rank test. Results Twenty patients were enrolled. The most common indication was constipation with encopresis. Seventy percent of patients had normal colonic manometry, and 30% of patients demonstrated a neuropathy. Average MI for the 60-minute period before and after EL infusion were 254 ± 74 mm Hg/h and 253 ± 94 mm Hg/h, respectively ( P = .55). Average MI for the 15-minute period before and after EL infusion were 64 ± 23 mm Hg/15 min and 69 ± 32 mm Hg/15 min, respectively ( P = .45). Conclusions Administration of intravenous EL resulted in no changes in colonic MI in pediatric patients referred for colonic manometry. Further studies on potential colokinetic agents are warranted in this population of patients.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2009.07.039</identifier><identifier>PMID: 20385286</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Colonic manometry ; Colonic motility ; Colonic Pseudo-Obstruction - drug therapy ; Constipation ; Constipation - drug therapy ; Encopresis - drug therapy ; Erythromycin ; Erythromycin - administration & dosage ; Erythromycin - analogs & derivatives ; Erythromycin - pharmacology ; Female ; Gastrointestinal Agents - administration & dosage ; Gastrointestinal Agents - pharmacology ; Gastrointestinal Motility - drug effects ; Humans ; Infusions, Intravenous ; Male ; Manometry ; Motility ; Pediatrics ; Pilot Projects ; Pseudoobstruction ; Surgery ; Young Adult</subject><ispartof>Journal of pediatric surgery, 2010-04, Vol.45 (4), p.777-783</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-96d55122db07f877017cabbb9fa7bb36b635e50f39a72cd45e1cdf47b1de95fb3</citedby><cites>FETCH-LOGICAL-c422t-96d55122db07f877017cabbb9fa7bb36b635e50f39a72cd45e1cdf47b1de95fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpedsurg.2009.07.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20385286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dranove, Jason</creatorcontrib><creatorcontrib>Horn, Debra</creatorcontrib><creatorcontrib>Reddy, S. Narasimha</creatorcontrib><creatorcontrib>Croffie, Joseph</creatorcontrib><title>Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Abstract Purpose Erythromycin is successfully used as a gastroduodenal prokinetic agent. Given the limited available treatments for colonic dysmotility, further investigation into erythromycin's effect on colonic motility is warranted. We aimed to study the effect of erythromycin on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods Patients referred for colonic manometry were eligible for enrollment. Fasting motility was recorded for 1 to 2 hours, then erythromycin lactobionate (EL), 3 mg/kg, was administered intravenously, and colonic motility was monitored for 1 to 2 hours after erythromycin. Manometry was then continued per routine. The motility index (MI) of pressure tracings at each pressure transducer was calculated for each patient for a period of 15 and 60 minutes before and after EL infusion. Change in MI was compared by Wilcoxon signed rank test. Results Twenty patients were enrolled. The most common indication was constipation with encopresis. Seventy percent of patients had normal colonic manometry, and 30% of patients demonstrated a neuropathy. Average MI for the 60-minute period before and after EL infusion were 254 ± 74 mm Hg/h and 253 ± 94 mm Hg/h, respectively ( P = .55). Average MI for the 15-minute period before and after EL infusion were 64 ± 23 mm Hg/15 min and 69 ± 32 mm Hg/15 min, respectively ( P = .45). Conclusions Administration of intravenous EL resulted in no changes in colonic MI in pediatric patients referred for colonic manometry. Further studies on potential colokinetic agents are warranted in this population of patients.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colonic manometry</subject><subject>Colonic motility</subject><subject>Colonic Pseudo-Obstruction - drug therapy</subject><subject>Constipation</subject><subject>Constipation - drug therapy</subject><subject>Encopresis - drug therapy</subject><subject>Erythromycin</subject><subject>Erythromycin - administration & dosage</subject><subject>Erythromycin - analogs & derivatives</subject><subject>Erythromycin - pharmacology</subject><subject>Female</subject><subject>Gastrointestinal Agents - administration & dosage</subject><subject>Gastrointestinal Agents - pharmacology</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Manometry</subject><subject>Motility</subject><subject>Pediatrics</subject><subject>Pilot Projects</subject><subject>Pseudoobstruction</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhL1S-cdowttdxckGgqnxIlTgAZ8uxx12HxF7spFL-fR1t2wMXTqMZve98PFNVVxRqCrT5MNTDCW1e0l3NALoaZA28e1HtqOB0L4DLl9UOgLE9PzTtRfUm5wGglIG-ri4Y8FawttlVpxvn0MwkOuLDnPQ9hrhkgmmdjylOq_GBxEDmIxITxxi8IVOc_ejndfOYox9twkB0sGSNS7gj2i7jnIldki_Zs0mHOOGc1rfVK6fHjO8e42X1-8vNr-tv-9sfX79ff77dmwNj875rrBCUMduDdK0sa0uj-77vnJZ9z5u-4QIFON5pyYw9CKTGuoPsqcVOuJ5fVu_PfU8p_l0wz2ry2eA46oDlQiU5b1tKG1aUzVlpUsw5oVOn5CedVkVBbbDVoJ5gqw22AqkK7GK8ehyx9BPaZ9sT3SL4dBZgOfTeY1LZeAwGrU8FurLR_3_Gx39amNEXoHr8gyvmIS4pFIyKqswUqJ_by7ePQwfQQCf4A5KyrBU</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Dranove, Jason</creator><creator>Horn, Debra</creator><creator>Reddy, S. Narasimha</creator><creator>Croffie, Joseph</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry</title><author>Dranove, Jason ; Horn, Debra ; Reddy, S. Narasimha ; Croffie, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-96d55122db07f877017cabbb9fa7bb36b635e50f39a72cd45e1cdf47b1de95fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Colonic manometry</topic><topic>Colonic motility</topic><topic>Colonic Pseudo-Obstruction - drug therapy</topic><topic>Constipation</topic><topic>Constipation - drug therapy</topic><topic>Encopresis - drug therapy</topic><topic>Erythromycin</topic><topic>Erythromycin - administration & dosage</topic><topic>Erythromycin - analogs & derivatives</topic><topic>Erythromycin - pharmacology</topic><topic>Female</topic><topic>Gastrointestinal Agents - administration & dosage</topic><topic>Gastrointestinal Agents - pharmacology</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Manometry</topic><topic>Motility</topic><topic>Pediatrics</topic><topic>Pilot Projects</topic><topic>Pseudoobstruction</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dranove, Jason</creatorcontrib><creatorcontrib>Horn, Debra</creatorcontrib><creatorcontrib>Reddy, S. Narasimha</creatorcontrib><creatorcontrib>Croffie, Joseph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dranove, Jason</au><au>Horn, Debra</au><au>Reddy, S. Narasimha</au><au>Croffie, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>45</volume><issue>4</issue><spage>777</spage><epage>783</epage><pages>777-783</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>Abstract Purpose Erythromycin is successfully used as a gastroduodenal prokinetic agent. Given the limited available treatments for colonic dysmotility, further investigation into erythromycin's effect on colonic motility is warranted. We aimed to study the effect of erythromycin on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods Patients referred for colonic manometry were eligible for enrollment. Fasting motility was recorded for 1 to 2 hours, then erythromycin lactobionate (EL), 3 mg/kg, was administered intravenously, and colonic motility was monitored for 1 to 2 hours after erythromycin. Manometry was then continued per routine. The motility index (MI) of pressure tracings at each pressure transducer was calculated for each patient for a period of 15 and 60 minutes before and after EL infusion. Change in MI was compared by Wilcoxon signed rank test. Results Twenty patients were enrolled. The most common indication was constipation with encopresis. Seventy percent of patients had normal colonic manometry, and 30% of patients demonstrated a neuropathy. Average MI for the 60-minute period before and after EL infusion were 254 ± 74 mm Hg/h and 253 ± 94 mm Hg/h, respectively ( P = .55). Average MI for the 15-minute period before and after EL infusion were 64 ± 23 mm Hg/15 min and 69 ± 32 mm Hg/15 min, respectively ( P = .45). Conclusions Administration of intravenous EL resulted in no changes in colonic MI in pediatric patients referred for colonic manometry. Further studies on potential colokinetic agents are warranted in this population of patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20385286</pmid><doi>10.1016/j.jpedsurg.2009.07.039</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Child Child, Preschool Colonic manometry Colonic motility Colonic Pseudo-Obstruction - drug therapy Constipation Constipation - drug therapy Encopresis - drug therapy Erythromycin Erythromycin - administration & dosage Erythromycin - analogs & derivatives Erythromycin - pharmacology Female Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - pharmacology Gastrointestinal Motility - drug effects Humans Infusions, Intravenous Male Manometry Motility Pediatrics Pilot Projects Pseudoobstruction Surgery Young Adult |
title | Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry |
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