High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva
Abstract Objective To assess the efficacy of high-intensity focused ultrasound (HIFU) treatment in patients with non-neoplastic epithelial disorders of the vulva. Method We reviewed 41 cases of lichen sclerosus, 38 cases of squamous cell hyperplasia, and 17 mixed cases treated by HIFU from April 200...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2010-05, Vol.109 (2), p.167-170 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Ruan, Liming Xie, Zhenwei Wang, Huiyun Jiang, Jingyi Shi, Haiyan Xu, Jian |
| description | Abstract Objective To assess the efficacy of high-intensity focused ultrasound (HIFU) treatment in patients with non-neoplastic epithelial disorders of the vulva. Method We reviewed 41 cases of lichen sclerosus, 38 cases of squamous cell hyperplasia, and 17 mixed cases treated by HIFU from April 2004 to July 2008 at the Women's Hospital of Zhejiang University School of Medicine. Biopsy specimens were assessed with light microscopy before and after treatment. Results Pruritus and signs of vulvar lesions were dramatically improved following HIFU treatment, without severe complications, and 90.23% of the patients were cured or had their symptoms improved 6 months after treatment. On light microscopy, pigmentation and epithelial structures were recovered and dermal lymphocytic infiltration was reduced. The response rates were lower and complication rates higher among lichen sclerosus than among squamous cell hyperplasia cases ( P < 0.05 for both). Conclusion Treatment with HIFU may be safe and effective in cases of vulvar dystrophy. |
| doi_str_mv | 10.1016/j.ijgo.2009.12.014 |
| format | Article |
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Method We reviewed 41 cases of lichen sclerosus, 38 cases of squamous cell hyperplasia, and 17 mixed cases treated by HIFU from April 2004 to July 2008 at the Women's Hospital of Zhejiang University School of Medicine. Biopsy specimens were assessed with light microscopy before and after treatment. Results Pruritus and signs of vulvar lesions were dramatically improved following HIFU treatment, without severe complications, and 90.23% of the patients were cured or had their symptoms improved 6 months after treatment. On light microscopy, pigmentation and epithelial structures were recovered and dermal lymphocytic infiltration was reduced. The response rates were lower and complication rates higher among lichen sclerosus than among squamous cell hyperplasia cases ( P < 0.05 for both). Conclusion Treatment with HIFU may be safe and effective in cases of vulvar dystrophy.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2009.12.014</identifier><identifier>PMID: 20153858</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Female ; Gynecology. Andrology. Obstetrics ; High-intensity focused ultrasound ; High-Intensity Focused Ultrasound Ablation ; Humans ; Hyperplasia - therapy ; Medical sciences ; Middle Aged ; Non-neoplastic epithelial disorders of the vulva ; Obstetrics and Gynecology ; Pruritus - therapy ; Treatment ; Treatment Outcome ; Vulva - pathology ; Vulvar Diseases - pathology ; Vulvar Diseases - therapy ; Vulvar Lichen Sclerosus - pathology ; Vulvar Lichen Sclerosus - therapy ; Young Adult</subject><ispartof>International journal of gynecology and obstetrics, 2010-05, Vol.109 (2), p.167-170</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2010 International Federation of Gynecology and Obstetrics</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4887-2f0780f527355ac50ff09ecac2651d684e226298a64cb7aa73d8b4d08d86a1983</citedby><cites>FETCH-LOGICAL-c4887-2f0780f527355ac50ff09ecac2651d684e226298a64cb7aa73d8b4d08d86a1983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2009.12.014$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2009.12.014$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22757778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20153858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruan, Liming</creatorcontrib><creatorcontrib>Xie, Zhenwei</creatorcontrib><creatorcontrib>Wang, Huiyun</creatorcontrib><creatorcontrib>Jiang, Jingyi</creatorcontrib><creatorcontrib>Shi, Haiyan</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><title>High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective To assess the efficacy of high-intensity focused ultrasound (HIFU) treatment in patients with non-neoplastic epithelial disorders of the vulva. Method We reviewed 41 cases of lichen sclerosus, 38 cases of squamous cell hyperplasia, and 17 mixed cases treated by HIFU from April 2004 to July 2008 at the Women's Hospital of Zhejiang University School of Medicine. Biopsy specimens were assessed with light microscopy before and after treatment. Results Pruritus and signs of vulvar lesions were dramatically improved following HIFU treatment, without severe complications, and 90.23% of the patients were cured or had their symptoms improved 6 months after treatment. On light microscopy, pigmentation and epithelial structures were recovered and dermal lymphocytic infiltration was reduced. The response rates were lower and complication rates higher among lichen sclerosus than among squamous cell hyperplasia cases ( P < 0.05 for both). Conclusion Treatment with HIFU may be safe and effective in cases of vulvar dystrophy.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>High-intensity focused ultrasound</subject><subject>High-Intensity Focused Ultrasound Ablation</subject><subject>Humans</subject><subject>Hyperplasia - therapy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non-neoplastic epithelial disorders of the vulva</subject><subject>Obstetrics and Gynecology</subject><subject>Pruritus - therapy</subject><subject>Treatment</subject><subject>Treatment Outcome</subject><subject>Vulva - pathology</subject><subject>Vulvar Diseases - pathology</subject><subject>Vulvar Diseases - therapy</subject><subject>Vulvar Lichen Sclerosus - pathology</subject><subject>Vulvar Lichen Sclerosus - therapy</subject><subject>Young Adult</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2PFCEQhonRuOPqH_Bg-mI8dVvQH9CJMTEb3V2zyR7UMzJQvcvIwAj0mPn30plREw_GEwk8b1E8FCHPKTQU6PB609jNXWgYwNhQ1gDtHpAVFXys246PD8kKgEHN2cjOyJOUNgBAOaWPyRkD2reiFyvy9cre3dfWZ_TJ5kM1BT0nNNXsclQpzN5UOaLKW_S5HMbKB197DDunUra6wp3N9-iscpWxKUSDMVVhqspmtZ_dXj0ljyblEj47refky4f3ny-u6pvby-uLdze17oTgNZuAC5h6xtu-V7qHaYIRtdJs6KkZRIeMDWwUauj0mivFWyPWnQFhxKDoKNpz8upYdxfD9xlTllubNDqnSrdzkrxthYCBsUKyI6ljSCniJHfRblU8SApyESs3chErF7GSMlnEltCLU_l5vUXzO_LLZAFengCVtHJTVF7b9IdjvOecLxw_cj-sw8N_XC2vP17e0oGX5JtjEovGvcUok7boNRobUWdpgv33C97-FdfOelt6_YYHTJswR18-SFKZSkB-WoZnmR0Ky9x0vP0Ji7G9sQ</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Ruan, Liming</creator><creator>Xie, Zhenwei</creator><creator>Wang, Huiyun</creator><creator>Jiang, Jingyi</creator><creator>Shi, Haiyan</creator><creator>Xu, Jian</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva</title><author>Ruan, Liming ; Xie, Zhenwei ; Wang, Huiyun ; Jiang, Jingyi ; Shi, Haiyan ; Xu, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4887-2f0780f527355ac50ff09ecac2651d684e226298a64cb7aa73d8b4d08d86a1983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>High-intensity focused ultrasound</topic><topic>High-Intensity Focused Ultrasound Ablation</topic><topic>Humans</topic><topic>Hyperplasia - therapy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non-neoplastic epithelial disorders of the vulva</topic><topic>Obstetrics and Gynecology</topic><topic>Pruritus - therapy</topic><topic>Treatment</topic><topic>Treatment Outcome</topic><topic>Vulva - pathology</topic><topic>Vulvar Diseases - pathology</topic><topic>Vulvar Diseases - therapy</topic><topic>Vulvar Lichen Sclerosus - pathology</topic><topic>Vulvar Lichen Sclerosus - therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruan, Liming</creatorcontrib><creatorcontrib>Xie, Zhenwei</creatorcontrib><creatorcontrib>Wang, Huiyun</creatorcontrib><creatorcontrib>Jiang, Jingyi</creatorcontrib><creatorcontrib>Shi, Haiyan</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruan, Liming</au><au>Xie, Zhenwei</au><au>Wang, Huiyun</au><au>Jiang, Jingyi</au><au>Shi, Haiyan</au><au>Xu, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2010-05</date><risdate>2010</risdate><volume>109</volume><issue>2</issue><spage>167</spage><epage>170</epage><pages>167-170</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objective To assess the efficacy of high-intensity focused ultrasound (HIFU) treatment in patients with non-neoplastic epithelial disorders of the vulva. Method We reviewed 41 cases of lichen sclerosus, 38 cases of squamous cell hyperplasia, and 17 mixed cases treated by HIFU from April 2004 to July 2008 at the Women's Hospital of Zhejiang University School of Medicine. Biopsy specimens were assessed with light microscopy before and after treatment. Results Pruritus and signs of vulvar lesions were dramatically improved following HIFU treatment, without severe complications, and 90.23% of the patients were cured or had their symptoms improved 6 months after treatment. On light microscopy, pigmentation and epithelial structures were recovered and dermal lymphocytic infiltration was reduced. The response rates were lower and complication rates higher among lichen sclerosus than among squamous cell hyperplasia cases ( P < 0.05 for both). Conclusion Treatment with HIFU may be safe and effective in cases of vulvar dystrophy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20153858</pmid><doi>10.1016/j.ijgo.2009.12.014</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Female Gynecology. Andrology. Obstetrics High-intensity focused ultrasound High-Intensity Focused Ultrasound Ablation Humans Hyperplasia - therapy Medical sciences Middle Aged Non-neoplastic epithelial disorders of the vulva Obstetrics and Gynecology Pruritus - therapy Treatment Treatment Outcome Vulva - pathology Vulvar Diseases - pathology Vulvar Diseases - therapy Vulvar Lichen Sclerosus - pathology Vulvar Lichen Sclerosus - therapy Young Adult |
| title | High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva |
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