Diet-induced acidosis: is it real and clinically relevant?
The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of our evolving understanding of physiological pH, the physiological support for the concept of ‘acidosis’, the causes of acidosis, how it is r...
Gespeichert in:
| Veröffentlicht in: | British journal of nutrition 2010-04, Vol.103 (8), p.1185-1194 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1194 |
|---|---|
| container_issue | 8 |
| container_start_page | 1185 |
| container_title | British journal of nutrition |
| container_volume | 103 |
| creator | Pizzorno, Joseph Frassetto, Lynda A. Katzinger, Joseph |
| description | The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of our evolving understanding of physiological pH, the physiological support for the concept of ‘acidosis’, the causes of acidosis, how it is recognised, its short-term effects as well as the long-term clinical relevance of preventative measures, and the research support for normalisation of pH. Further, we suggest differentiation of the terms ‘acidosis’ and ‘acidaemia’ as a way to resolve the conflation of these topics which has led to confusion and controversy. The available research makes a compelling case that diet-induced acidosis, not diet-induced acidaemia, is a real phenomenon, and has a significant, clinical, long-term pathophysiological effect that should be recognised and potentially counterbalanced by dietary means. |
| doi_str_mv | 10.1017/S0007114509993047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733879870</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0007114509993047</cupid><sourcerecordid>2007053281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-934aead26c3be32790c82b8f39af533b2095a54e5f6492fd8cee8f183bb876013</originalsourceid><addsrcrecordid>eNp1kFtv1DAQhS0EokvhB_ACERLiKWB74ltfKlhgQaq4qFRCvFgTx65cskmxE0T_PY52aSUQT7Znvjnjcwh5yOhzRpl6cUopVYw1ghpjgDbqFlmxRomaS8lvk9XSrpf-AbmX80V5akbNXXLAyxUkFyty9Dr6qY5DNzvfVehiN-aYj6qYqzhVyWNf4dBVro9DdNj3V6XW-584TMf3yZ2AffYP9uchOXv75sv6XX3ycfN-_fKkdoLKqTbQoMeOSwetB64MdZq3OoDBIABaTo1A0XgRZGN46LTzXgemoW21kpTBIXm2071M44_Z58luY3a-73Hw45ytAtDKaEUL-eQv8mKc01A-ZzkDDZIZXSC2g1wac04-2MsUt5iuLKN2idX-E2uZebQXntut764n_uRYgKd7AHOJKSQcXMw3HJdaGFiW1zsu5sn_uu5j-m6lAiWs3Hy2X-mnD9_Wr8BuCv94xwccLZ6nonl2yksotAREgS6bYW8Ht22K3bm_Mf1_Q78BiB-kEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213836198</pqid></control><display><type>article</type><title>Diet-induced acidosis: is it real and clinically relevant?</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><source>Cambridge University Press Journals Complete</source><creator>Pizzorno, Joseph ; Frassetto, Lynda A. ; Katzinger, Joseph</creator><creatorcontrib>Pizzorno, Joseph ; Frassetto, Lynda A. ; Katzinger, Joseph</creatorcontrib><description>The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of our evolving understanding of physiological pH, the physiological support for the concept of ‘acidosis’, the causes of acidosis, how it is recognised, its short-term effects as well as the long-term clinical relevance of preventative measures, and the research support for normalisation of pH. Further, we suggest differentiation of the terms ‘acidosis’ and ‘acidaemia’ as a way to resolve the conflation of these topics which has led to confusion and controversy. The available research makes a compelling case that diet-induced acidosis, not diet-induced acidaemia, is a real phenomenon, and has a significant, clinical, long-term pathophysiological effect that should be recognised and potentially counterbalanced by dietary means.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114509993047</identifier><identifier>PMID: 20003625</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>acid-base balance ; acidemia ; Acidosis ; Acidosis - blood ; Acidosis - etiology ; Acidosis - physiopathology ; Acids ; Acid–base equilibrium ; Algorithms ; Bicarbonates - analysis ; Biological and medical sciences ; Bone Density ; Bone Resorption - etiology ; Carbon Dioxide - analysis ; Diet ; Diet-induced acidosis ; diet-related diseases ; disease diagnosis ; Endogenous acid production ; etiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; history ; Homeostasis ; Human and Clinical Nutrition ; human diseases ; human nutrition ; human physiology ; Humans ; Hydrogen-Ion Concentration ; insulin resistance ; Kidney Calculi - complications ; Kidney Calculi - etiology ; Kidney Calculi - prevention & control ; literature reviews ; medical treatment ; Metabolic acidosis ; Middle Aged ; Muscle, Skeletal - physiology ; muscles ; Nutrition research ; Phosphorus ; Physiology ; Protons ; renal calculi ; Renal net acid excretion ; Respiratory Physiological Phenomena ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2010-04, Vol.103 (8), p.1185-1194</ispartof><rights>Copyright © The Authors 2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-934aead26c3be32790c82b8f39af533b2095a54e5f6492fd8cee8f183bb876013</citedby><cites>FETCH-LOGICAL-c506t-934aead26c3be32790c82b8f39af533b2095a54e5f6492fd8cee8f183bb876013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114509993047/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22685938$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20003625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pizzorno, Joseph</creatorcontrib><creatorcontrib>Frassetto, Lynda A.</creatorcontrib><creatorcontrib>Katzinger, Joseph</creatorcontrib><title>Diet-induced acidosis: is it real and clinically relevant?</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of our evolving understanding of physiological pH, the physiological support for the concept of ‘acidosis’, the causes of acidosis, how it is recognised, its short-term effects as well as the long-term clinical relevance of preventative measures, and the research support for normalisation of pH. Further, we suggest differentiation of the terms ‘acidosis’ and ‘acidaemia’ as a way to resolve the conflation of these topics which has led to confusion and controversy. The available research makes a compelling case that diet-induced acidosis, not diet-induced acidaemia, is a real phenomenon, and has a significant, clinical, long-term pathophysiological effect that should be recognised and potentially counterbalanced by dietary means.</description><subject>acid-base balance</subject><subject>acidemia</subject><subject>Acidosis</subject><subject>Acidosis - blood</subject><subject>Acidosis - etiology</subject><subject>Acidosis - physiopathology</subject><subject>Acids</subject><subject>Acid–base equilibrium</subject><subject>Algorithms</subject><subject>Bicarbonates - analysis</subject><subject>Biological and medical sciences</subject><subject>Bone Density</subject><subject>Bone Resorption - etiology</subject><subject>Carbon Dioxide - analysis</subject><subject>Diet</subject><subject>Diet-induced acidosis</subject><subject>diet-related diseases</subject><subject>disease diagnosis</subject><subject>Endogenous acid production</subject><subject>etiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>history</subject><subject>Homeostasis</subject><subject>Human and Clinical Nutrition</subject><subject>human diseases</subject><subject>human nutrition</subject><subject>human physiology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>insulin resistance</subject><subject>Kidney Calculi - complications</subject><subject>Kidney Calculi - etiology</subject><subject>Kidney Calculi - prevention & control</subject><subject>literature reviews</subject><subject>medical treatment</subject><subject>Metabolic acidosis</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - physiology</subject><subject>muscles</subject><subject>Nutrition research</subject><subject>Phosphorus</subject><subject>Physiology</subject><subject>Protons</subject><subject>renal calculi</subject><subject>Renal net acid excretion</subject><subject>Respiratory Physiological Phenomena</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kFtv1DAQhS0EokvhB_ACERLiKWB74ltfKlhgQaq4qFRCvFgTx65cskmxE0T_PY52aSUQT7Znvjnjcwh5yOhzRpl6cUopVYw1ghpjgDbqFlmxRomaS8lvk9XSrpf-AbmX80V5akbNXXLAyxUkFyty9Dr6qY5DNzvfVehiN-aYj6qYqzhVyWNf4dBVro9DdNj3V6XW-584TMf3yZ2AffYP9uchOXv75sv6XX3ycfN-_fKkdoLKqTbQoMeOSwetB64MdZq3OoDBIABaTo1A0XgRZGN46LTzXgemoW21kpTBIXm2071M44_Z58luY3a-73Hw45ytAtDKaEUL-eQv8mKc01A-ZzkDDZIZXSC2g1wac04-2MsUt5iuLKN2idX-E2uZebQXntut764n_uRYgKd7AHOJKSQcXMw3HJdaGFiW1zsu5sn_uu5j-m6lAiWs3Hy2X-mnD9_Wr8BuCv94xwccLZ6nonl2yksotAREgS6bYW8Ht22K3bm_Mf1_Q78BiB-kEA</recordid><startdate>20100428</startdate><enddate>20100428</enddate><creator>Pizzorno, Joseph</creator><creator>Frassetto, Lynda A.</creator><creator>Katzinger, Joseph</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100428</creationdate><title>Diet-induced acidosis: is it real and clinically relevant?</title><author>Pizzorno, Joseph ; Frassetto, Lynda A. ; Katzinger, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-934aead26c3be32790c82b8f39af533b2095a54e5f6492fd8cee8f183bb876013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acid-base balance</topic><topic>acidemia</topic><topic>Acidosis</topic><topic>Acidosis - blood</topic><topic>Acidosis - etiology</topic><topic>Acidosis - physiopathology</topic><topic>Acids</topic><topic>Acid–base equilibrium</topic><topic>Algorithms</topic><topic>Bicarbonates - analysis</topic><topic>Biological and medical sciences</topic><topic>Bone Density</topic><topic>Bone Resorption - etiology</topic><topic>Carbon Dioxide - analysis</topic><topic>Diet</topic><topic>Diet-induced acidosis</topic><topic>diet-related diseases</topic><topic>disease diagnosis</topic><topic>Endogenous acid production</topic><topic>etiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>history</topic><topic>Homeostasis</topic><topic>Human and Clinical Nutrition</topic><topic>human diseases</topic><topic>human nutrition</topic><topic>human physiology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>insulin resistance</topic><topic>Kidney Calculi - complications</topic><topic>Kidney Calculi - etiology</topic><topic>Kidney Calculi - prevention & control</topic><topic>literature reviews</topic><topic>medical treatment</topic><topic>Metabolic acidosis</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - physiology</topic><topic>muscles</topic><topic>Nutrition research</topic><topic>Phosphorus</topic><topic>Physiology</topic><topic>Protons</topic><topic>renal calculi</topic><topic>Renal net acid excretion</topic><topic>Respiratory Physiological Phenomena</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pizzorno, Joseph</creatorcontrib><creatorcontrib>Frassetto, Lynda A.</creatorcontrib><creatorcontrib>Katzinger, Joseph</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pizzorno, Joseph</au><au>Frassetto, Lynda A.</au><au>Katzinger, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet-induced acidosis: is it real and clinically relevant?</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2010-04-28</date><risdate>2010</risdate><volume>103</volume><issue>8</issue><spage>1185</spage><epage>1194</epage><pages>1185-1194</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of our evolving understanding of physiological pH, the physiological support for the concept of ‘acidosis’, the causes of acidosis, how it is recognised, its short-term effects as well as the long-term clinical relevance of preventative measures, and the research support for normalisation of pH. Further, we suggest differentiation of the terms ‘acidosis’ and ‘acidaemia’ as a way to resolve the conflation of these topics which has led to confusion and controversy. The available research makes a compelling case that diet-induced acidosis, not diet-induced acidaemia, is a real phenomenon, and has a significant, clinical, long-term pathophysiological effect that should be recognised and potentially counterbalanced by dietary means.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>20003625</pmid><doi>10.1017/S0007114509993047</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2010-04, Vol.103 (8), p.1185-1194 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733879870 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | acid-base balance acidemia Acidosis Acidosis - blood Acidosis - etiology Acidosis - physiopathology Acids Acid–base equilibrium Algorithms Bicarbonates - analysis Biological and medical sciences Bone Density Bone Resorption - etiology Carbon Dioxide - analysis Diet Diet-induced acidosis diet-related diseases disease diagnosis Endogenous acid production etiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology history Homeostasis Human and Clinical Nutrition human diseases human nutrition human physiology Humans Hydrogen-Ion Concentration insulin resistance Kidney Calculi - complications Kidney Calculi - etiology Kidney Calculi - prevention & control literature reviews medical treatment Metabolic acidosis Middle Aged Muscle, Skeletal - physiology muscles Nutrition research Phosphorus Physiology Protons renal calculi Renal net acid excretion Respiratory Physiological Phenomena Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Diet-induced acidosis: is it real and clinically relevant? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T02%3A29%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diet-induced%20acidosis:%20is%20it%20real%20and%20clinically%20relevant?&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Pizzorno,%20Joseph&rft.date=2010-04-28&rft.volume=103&rft.issue=8&rft.spage=1185&rft.epage=1194&rft.pages=1185-1194&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114509993047&rft_dat=%3Cproquest_cross%3E2007053281%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213836198&rft_id=info:pmid/20003625&rft_cupid=10_1017_S0007114509993047&rfr_iscdi=true |