White matter microstructure underlying default mode network connectivity in the human brain
Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotro...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2010-02, Vol.49 (3), p.2021-2032 |
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| creator | Teipel, Stefan J. Bokde, Arun L.W. Meindl, Thomas Amaro, Edson Soldner, Jasmin Reiser, Maximilian F. Herpertz, Sabine C. Möller, Hans-Jürgen Hampel, Harald |
| description | Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotropy measures of fiber tract integrity derived from diffusion tensor imaging (DTI) and resting state fMRI data obtained at 3 Tesla from 20 healthy elderly subjects (56 to 83 years of age) to determine white matter microstructure underlying default mode connectivity. We hypothesized that the functional connectivity between the posterior cingulate and hippocampus from resting state fMRI data would be associated with the white matter microstructure in the cingulate bundle and fiber tracts connecting posterior cingulate gyrus with lateral temporal lobes, medial temporal lobes, and precuneus. This was demonstrated at the p |
| doi_str_mv | 10.1016/j.neuroimage.2009.10.067 |
| format | Article |
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The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotropy measures of fiber tract integrity derived from diffusion tensor imaging (DTI) and resting state fMRI data obtained at 3 Tesla from 20 healthy elderly subjects (56 to 83 years of age) to determine white matter microstructure underlying default mode connectivity. We hypothesized that the functional connectivity between the posterior cingulate and hippocampus from resting state fMRI data would be associated with the white matter microstructure in the cingulate bundle and fiber tracts connecting posterior cingulate gyrus with lateral temporal lobes, medial temporal lobes, and precuneus. This was demonstrated at the p<0.001 level using a voxel-based multivariate analysis of covariance (MANCOVA) approach. In addition, we used a data-driven technique of joint independent component analysis (ICA) that uncovers spatial pattern that are linked across modalities. It revealed a pattern of white matter tracts including cingulate bundle and associated fiber tracts resembling the findings from the hypothesis-driven analysis and was linked to the pattern of default mode network (DMN) connectivity in the resting state fMRI data. Our findings support the notion that the functional connectivity between the posterior cingulate and hippocampus and the functional connectivity across the entire DMN is based on distinct pattern of anatomical connectivity within the cerebral white matter.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2009.10.067</identifier><identifier>PMID: 19878723</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acquisitions & mergers ; Aged ; Aged, 80 and over ; Brain ; Brain - anatomy & histology ; Brain function ; Brain Mapping ; Default mode ; Diffusion Tensor Imaging ; DTI ; Female ; Functional connectivity ; Humans ; Male ; Microstructure ; Middle Aged ; Multivariate analysis ; Neural Pathways - anatomy & histology ; NMR ; Nuclear magnetic resonance ; Principal Component Analysis ; Resting state fMRI ; Structural connectivity ; Studies</subject><ispartof>NeuroImage (Orlando, Fla.), 2010-02, Vol.49 (3), p.2021-2032</ispartof><rights>2009 Elsevier Inc.</rights><rights>Copyright (c) 2009 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 1, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-3eb4302fba928680a060f20e926d2d2bd5b8c1150844c50bca5a7af8eff43d833</citedby><cites>FETCH-LOGICAL-c548t-3eb4302fba928680a060f20e926d2d2bd5b8c1150844c50bca5a7af8eff43d833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1053811909011380$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19878723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teipel, Stefan J.</creatorcontrib><creatorcontrib>Bokde, Arun L.W.</creatorcontrib><creatorcontrib>Meindl, Thomas</creatorcontrib><creatorcontrib>Amaro, Edson</creatorcontrib><creatorcontrib>Soldner, Jasmin</creatorcontrib><creatorcontrib>Reiser, Maximilian F.</creatorcontrib><creatorcontrib>Herpertz, Sabine C.</creatorcontrib><creatorcontrib>Möller, Hans-Jürgen</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><title>White matter microstructure underlying default mode network connectivity in the human brain</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotropy measures of fiber tract integrity derived from diffusion tensor imaging (DTI) and resting state fMRI data obtained at 3 Tesla from 20 healthy elderly subjects (56 to 83 years of age) to determine white matter microstructure underlying default mode connectivity. We hypothesized that the functional connectivity between the posterior cingulate and hippocampus from resting state fMRI data would be associated with the white matter microstructure in the cingulate bundle and fiber tracts connecting posterior cingulate gyrus with lateral temporal lobes, medial temporal lobes, and precuneus. This was demonstrated at the p<0.001 level using a voxel-based multivariate analysis of covariance (MANCOVA) approach. In addition, we used a data-driven technique of joint independent component analysis (ICA) that uncovers spatial pattern that are linked across modalities. It revealed a pattern of white matter tracts including cingulate bundle and associated fiber tracts resembling the findings from the hypothesis-driven analysis and was linked to the pattern of default mode network (DMN) connectivity in the resting state fMRI data. 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The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotropy measures of fiber tract integrity derived from diffusion tensor imaging (DTI) and resting state fMRI data obtained at 3 Tesla from 20 healthy elderly subjects (56 to 83 years of age) to determine white matter microstructure underlying default mode connectivity. We hypothesized that the functional connectivity between the posterior cingulate and hippocampus from resting state fMRI data would be associated with the white matter microstructure in the cingulate bundle and fiber tracts connecting posterior cingulate gyrus with lateral temporal lobes, medial temporal lobes, and precuneus. This was demonstrated at the p<0.001 level using a voxel-based multivariate analysis of covariance (MANCOVA) approach. In addition, we used a data-driven technique of joint independent component analysis (ICA) that uncovers spatial pattern that are linked across modalities. It revealed a pattern of white matter tracts including cingulate bundle and associated fiber tracts resembling the findings from the hypothesis-driven analysis and was linked to the pattern of default mode network (DMN) connectivity in the resting state fMRI data. Our findings support the notion that the functional connectivity between the posterior cingulate and hippocampus and the functional connectivity across the entire DMN is based on distinct pattern of anatomical connectivity within the cerebral white matter.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19878723</pmid><doi>10.1016/j.neuroimage.2009.10.067</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquisitions & mergers Aged Aged, 80 and over Brain Brain - anatomy & histology Brain function Brain Mapping Default mode Diffusion Tensor Imaging DTI Female Functional connectivity Humans Male Microstructure Middle Aged Multivariate analysis Neural Pathways - anatomy & histology NMR Nuclear magnetic resonance Principal Component Analysis Resting state fMRI Structural connectivity Studies |
| title | White matter microstructure underlying default mode network connectivity in the human brain |
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