The skewed usage of T cell receptor beta variable chain at the maternal-fetal interface of women with unexplained recurrent spontaneous abortion
To investigate T cell receptor (TCR) variable beta (BV) chain usage at the maternal-fetal interface and explore the relationship between the skewed TCR BV usage and unexplained recurrent spontaneous abortion (RSA). Eighteen cases with unexplained RSA, together with matched 41 women with normal pregn...
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| Veröffentlicht in: | Chung-hua fu chʿan kʿo tsa chih 2008-10, Vol.43 (10), p.751-756 |
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| container_title | Chung-hua fu chʿan kʿo tsa chih |
| container_volume | 43 |
| creator | Wang, Xi-Peng Lin, Qi-de Ma, Zheng-Wen Hong, Yan Lu, Pei-Hua |
| description | To investigate T cell receptor (TCR) variable beta (BV) chain usage at the maternal-fetal interface and explore the relationship between the skewed TCR BV usage and unexplained recurrent spontaneous abortion (RSA).
Eighteen cases with unexplained RSA, together with matched 41 women with normal pregnancies in first trimester from Renji Hospital, Shanghai Jiao Tong University were studied. A high-resolution spectrum typing analysis of complementarity-determining region 3 (CDR3) was used to detect and compare the degree and frequency of TCR BV family expression in deciduas between RSA patients and normal controls.
(1) The expression degree of BV19 (0.029 +/- 0.031 vs. 0.013 +/- 0.010, P = 0.038) in RSA group showed a higher usage, while BV5.2 (0.040 +/- 0.035 vs. 0.067 +/- 0.052, P = 0.046) showed a significantly lower usage when compared with normal controls. No significant difference in the expression of the other TCR BV families between RSA and controls were observed (P > 0.05). (2) TCR BV2, 3, 6, and 7 were |
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Eighteen cases with unexplained RSA, together with matched 41 women with normal pregnancies in first trimester from Renji Hospital, Shanghai Jiao Tong University were studied. A high-resolution spectrum typing analysis of complementarity-determining region 3 (CDR3) was used to detect and compare the degree and frequency of TCR BV family expression in deciduas between RSA patients and normal controls.
(1) The expression degree of BV19 (0.029 +/- 0.031 vs. 0.013 +/- 0.010, P = 0.038) in RSA group showed a higher usage, while BV5.2 (0.040 +/- 0.035 vs. 0.067 +/- 0.052, P = 0.046) showed a significantly lower usage when compared with normal controls. No significant difference in the expression of the other TCR BV families between RSA and controls were observed (P > 0.05). (2) TCR BV2, 3, 6, and 7 were</description><identifier>ISSN: 0529-567X</identifier><identifier>PMID: 19087541</identifier><language>chi</language><publisher>China</publisher><subject>Abortion, Habitual - genetics ; Abortion, Habitual - immunology ; Abortion, Habitual - metabolism ; Adult ; Case-Control Studies ; Complementarity Determining Regions - genetics ; Complementarity Determining Regions - immunology ; Decidua - immunology ; Decidua - metabolism ; Female ; Gene Expression ; Gene Frequency ; Humans ; Polymerase Chain Reaction ; Pregnancy ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, alpha-beta - immunology ; Receptors, Antigen, T-Cell, alpha-beta - metabolism</subject><ispartof>Chung-hua fu chʿan kʿo tsa chih, 2008-10, Vol.43 (10), p.751-756</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19087541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xi-Peng</creatorcontrib><creatorcontrib>Lin, Qi-de</creatorcontrib><creatorcontrib>Ma, Zheng-Wen</creatorcontrib><creatorcontrib>Hong, Yan</creatorcontrib><creatorcontrib>Lu, Pei-Hua</creatorcontrib><title>The skewed usage of T cell receptor beta variable chain at the maternal-fetal interface of women with unexplained recurrent spontaneous abortion</title><title>Chung-hua fu chʿan kʿo tsa chih</title><addtitle>Zhonghua Fu Chan Ke Za Zhi</addtitle><description>To investigate T cell receptor (TCR) variable beta (BV) chain usage at the maternal-fetal interface and explore the relationship between the skewed TCR BV usage and unexplained recurrent spontaneous abortion (RSA).
Eighteen cases with unexplained RSA, together with matched 41 women with normal pregnancies in first trimester from Renji Hospital, Shanghai Jiao Tong University were studied. A high-resolution spectrum typing analysis of complementarity-determining region 3 (CDR3) was used to detect and compare the degree and frequency of TCR BV family expression in deciduas between RSA patients and normal controls.
(1) The expression degree of BV19 (0.029 +/- 0.031 vs. 0.013 +/- 0.010, P = 0.038) in RSA group showed a higher usage, while BV5.2 (0.040 +/- 0.035 vs. 0.067 +/- 0.052, P = 0.046) showed a significantly lower usage when compared with normal controls. No significant difference in the expression of the other TCR BV families between RSA and controls were observed (P > 0.05). (2) TCR BV2, 3, 6, and 7 were</description><subject>Abortion, Habitual - genetics</subject><subject>Abortion, Habitual - immunology</subject><subject>Abortion, Habitual - metabolism</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Complementarity Determining Regions - genetics</subject><subject>Complementarity Determining Regions - immunology</subject><subject>Decidua - immunology</subject><subject>Decidua - metabolism</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Humans</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - metabolism</subject><issn>0529-567X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRbMA0ar0F5B3rCLFcR7OElW8pEpsisQuGttjapHYwXYo_AWfjKFFsxiNdO6dO3OWLYu67PK6aV8W2ToEI4qasoaXtLvIFrQreFtXdJl97_ZIwhseUJE5wCsSp8mOSBwG4lHiFJ0nAiOQD_AGxIBE7sFYApHEJB0horcw5DoxAzE2jRrkn83BjWjJwcQ9mS1-TkPSpTXJdvYebSRhcjaCRTcHAsL5aJy9zM41DAHXp77Knu9ud5uHfPt0_7i52eYTLeuYN1p2ZcG0hgpkqSrNVMu4AAo8laa67opG0ho5pUrRxMlKgRK6AYG8Kdgquz76Tt69zxhiP5rwe_YxT98yxtuGsy6RVydyFiOqfvJmBP_V_z-R_QAdnXKY</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Wang, Xi-Peng</creator><creator>Lin, Qi-de</creator><creator>Ma, Zheng-Wen</creator><creator>Hong, Yan</creator><creator>Lu, Pei-Hua</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>The skewed usage of T cell receptor beta variable chain at the maternal-fetal interface of women with unexplained recurrent spontaneous abortion</title><author>Wang, Xi-Peng ; Lin, Qi-de ; Ma, Zheng-Wen ; Hong, Yan ; Lu, Pei-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-6fc9203ffa4ac2d4f3d738ba1a8a8af1f5906c15e811dd1ffac4dadbf6abe8603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2008</creationdate><topic>Abortion, Habitual - genetics</topic><topic>Abortion, Habitual - immunology</topic><topic>Abortion, Habitual - metabolism</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Complementarity Determining Regions - genetics</topic><topic>Complementarity Determining Regions - immunology</topic><topic>Decidua - immunology</topic><topic>Decidua - metabolism</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>Humans</topic><topic>Polymerase Chain Reaction</topic><topic>Pregnancy</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - immunology</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xi-Peng</creatorcontrib><creatorcontrib>Lin, Qi-de</creatorcontrib><creatorcontrib>Ma, Zheng-Wen</creatorcontrib><creatorcontrib>Hong, Yan</creatorcontrib><creatorcontrib>Lu, Pei-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chung-hua fu chʿan kʿo tsa chih</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xi-Peng</au><au>Lin, Qi-de</au><au>Ma, Zheng-Wen</au><au>Hong, Yan</au><au>Lu, Pei-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The skewed usage of T cell receptor beta variable chain at the maternal-fetal interface of women with unexplained recurrent spontaneous abortion</atitle><jtitle>Chung-hua fu chʿan kʿo tsa chih</jtitle><addtitle>Zhonghua Fu Chan Ke Za Zhi</addtitle><date>2008-10</date><risdate>2008</risdate><volume>43</volume><issue>10</issue><spage>751</spage><epage>756</epage><pages>751-756</pages><issn>0529-567X</issn><abstract>To investigate T cell receptor (TCR) variable beta (BV) chain usage at the maternal-fetal interface and explore the relationship between the skewed TCR BV usage and unexplained recurrent spontaneous abortion (RSA).
Eighteen cases with unexplained RSA, together with matched 41 women with normal pregnancies in first trimester from Renji Hospital, Shanghai Jiao Tong University were studied. A high-resolution spectrum typing analysis of complementarity-determining region 3 (CDR3) was used to detect and compare the degree and frequency of TCR BV family expression in deciduas between RSA patients and normal controls.
(1) The expression degree of BV19 (0.029 +/- 0.031 vs. 0.013 +/- 0.010, P = 0.038) in RSA group showed a higher usage, while BV5.2 (0.040 +/- 0.035 vs. 0.067 +/- 0.052, P = 0.046) showed a significantly lower usage when compared with normal controls. No significant difference in the expression of the other TCR BV families between RSA and controls were observed (P > 0.05). (2) TCR BV2, 3, 6, and 7 were</abstract><cop>China</cop><pmid>19087541</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Abortion, Habitual - genetics Abortion, Habitual - immunology Abortion, Habitual - metabolism Adult Case-Control Studies Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology Decidua - immunology Decidua - metabolism Female Gene Expression Gene Frequency Humans Polymerase Chain Reaction Pregnancy Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, alpha-beta - metabolism |
| title | The skewed usage of T cell receptor beta variable chain at the maternal-fetal interface of women with unexplained recurrent spontaneous abortion |
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