Gal knockout pig pericardium: New source of material for heart valve bioprostheses

Background Although glutaraldehyde fixation is known to reduce immunogenicity and degeneration of heart valve bioprostheses, some degree of immunogenicity persists, which may trigger calcification. The aims of this study were to: (1) define the role of alpha-1,3-galactosyltransferase (α-Gal) antigen...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2010-05, Vol.29 (5), p.538-543
Hauptverfasser:	Lila, Nermine, DVM, PhD, McGregor, Christopher G.A., MD, PhD, Carpentier, Sophie, PhD, Rancic, Jeanne, Byrne, Guerard W., PhD, Carpentier, Alain, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-gal Animals Animals, Genetically Modified anti-gal antibodies Antibodies, Heterophile - analysis Biological and medical sciences Bioprosthesis calcification Calcinosis - immunology Calcinosis - pathology Cardiology. Vascular system Equipment Failure Analysis Galactosyltransferases - genetics Gene Knockout Techniques heart valve bioprostheses Heart Valve Prosthesis Humans immunogenicity Medical sciences Microscopy, Fluorescence Pericardium - immunology Pericardium - pathology Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Swine - genetics Tissue Fixation Transplantation, Heterologous
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