A Phase II Trial of FOLFOX6 and Cetuximab in the First-line Treatment of Patients With Metastatic Colorectal Cancer

Abstract Introduction This phase II trial evaluated the efficacy and safety of cetuximab combined with FOLFOX6 (leucovorin [LV] 5-fluorouracil [5-FU]/oxaliplatin) in the first-line treatment of patients with advanced or metastatic colorectal cancer. Patients and Methods Patients with locally advance...

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Veröffentlicht in:	Clinical colorectal cancer 2010-04, Vol.9 (2), p.102-107
Hauptverfasser:	Boccia, Ralph V, Cosgriff, Thomas M, Headley, David L, Badarinath, Suprith, Dakhil, Shaker R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Biomarkers, Tumor BRAF Cetuximab Colorectal Neoplasms - drug therapy Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Confidence Intervals Disease Progression Drug Therapy, Combination EGFR Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - therapeutic use Gastroenterology and Hepatology Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate KRAS Leucovorin - administration & dosage Leucovorin - adverse effects Leucovorin - therapeutic use Male Middle Aged Neutropenia Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Organoplatinum Compounds - therapeutic use Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) ras Proteins Skin toxicity Treatment Outcome United States
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