Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents
A new series of functionalized amino acid derivatives N-substituted 1-N-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyl-5-oxazolidine carboxamide (1-17) and 1-N-substituted-3-amino-2-hydroxy-3-phenylpropane-1-carboxamide (18-34) were synthesized and evaluated for their in vitro cytotoxicity against huma...
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2009-06, Vol.24 (3), p.763-770 |
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| container_title | Journal of enzyme inhibition and medicinal chemistry |
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| creator | Kumar, Vivek Mudgal, Mukesh M. Rani, Nidhi Jha, Amrita Jaggi, Manu Singh, Anu T. Sanna, Vinod K. Singh, Pratibha Sharma, Pramod K. Irchhaiya, Raghuveer Burman, Anand C. |
| description | A new series of functionalized amino acid derivatives N-substituted 1-N-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyl-5-oxazolidine carboxamide (1-17) and 1-N-substituted-3-amino-2-hydroxy-3-phenylpropane-1-carboxamide (18-34) were synthesized and evaluated for their in vitro cytotoxicity against human cancer cell lines. Compound 6 has shown interesting cytotoxicity (IC50 = 5.67 μm) in ovarian cancer, while compound 10 exhibited promising cytotoxicity in ovarian (IC50 = 6.1 μm) and oral (IC50 = 4.17 μm) cancers. These compounds could be of use in designing new anti-cancer agents. |
| doi_str_mv | 10.1080/14756360802362975 |
| format | Article |
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Compound 6 has shown interesting cytotoxicity (IC50 = 5.67 μm) in ovarian cancer, while compound 10 exhibited promising cytotoxicity in ovarian (IC50 = 6.1 μm) and oral (IC50 = 4.17 μm) cancers. 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Compound 6 has shown interesting cytotoxicity (IC50 = 5.67 μm) in ovarian cancer, while compound 10 exhibited promising cytotoxicity in ovarian (IC50 = 6.1 μm) and oral (IC50 = 4.17 μm) cancers. These compounds could be of use in designing new anti-cancer agents.</description><subject>Amides - chemical synthesis</subject><subject>Amides - chemistry</subject><subject>Amides - pharmacology</subject><subject>Amino Acids - chemistry</subject><subject>Anticancer</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>carboxamide</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Drug Design</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>functionalized amino acid</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Mouth Neoplasms - pathology</subject><subject>Ovarian Neoplasms - pathology</subject><issn>1475-6366</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rr6A7xIbp5Gk3Q6SaMXWfyCBQ_qOdQkleks3cmYdO8y--vNMoMiwp5SFM_7Ep4i5CVnbzgz7C2XuledaqPolBh0_4ic3-82qtPy8Z9ZqTPyrNZrxgQXXD4lZ9xowfjAzsn4_ZCWEWusNAca1uSWmBNM8Q49hTmmTMFFTz2WeANLvMFKodKEt3Q_QpnB5f2YS9uGXBpV4y7FtKOQluggOSwUdpiW-pw8CTBVfHF6L8jPTx9_XH7ZXH37_PXyw9XGSWmWjRJmG7ziTHqHfCsMIA9GmcEzHSRK1vN-ENr0fZBboWCQWoAemMdByqBdd0FeH3v3Jf9asS52jtXhNEHCvFaru86oZo03kh9JV3KtBYPdlzhDOVjO7L1f-5_flnl1al-3M_q_iZPQBrw_AjE1ITPc5jJ5u8BhyiWUJiRW2z3U_-6f-IgwLaODgvY6r6Udpj7wu9-c5ZxI</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Kumar, Vivek</creator><creator>Mudgal, Mukesh M.</creator><creator>Rani, Nidhi</creator><creator>Jha, Amrita</creator><creator>Jaggi, Manu</creator><creator>Singh, Anu T.</creator><creator>Sanna, Vinod K.</creator><creator>Singh, Pratibha</creator><creator>Sharma, Pramod K.</creator><creator>Irchhaiya, Raghuveer</creator><creator>Burman, Anand C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents</title><author>Kumar, Vivek ; 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| subjects | Amides - chemical synthesis Amides - chemistry Amides - pharmacology Amino Acids - chemistry Anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology carboxamide Cell Line Cell Line, Tumor Drug Design Drug Screening Assays, Antitumor Female Fibroblasts - cytology Fibroblasts - drug effects functionalized amino acid Humans Inhibitory Concentration 50 Mouth Neoplasms - pathology Ovarian Neoplasms - pathology |
| title | Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents |
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