Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?
Background The purpose of this retrospective analysis was to determine if a short course of prophylactic proton pump inhibitor (PPI) therapy can prevent stomal ulceration after laparoscopic Roux-en-Y gastric bypass (LRYGBP). Methods Four hundred forty-nine consecutive patients who underwent LRYGBP a...
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| Veröffentlicht in: | Obesity surgery 2010-05, Vol.20 (5), p.595-599 |
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| creator | André D’Hondt, Mathieu Pottel, Hans Devriendt, Dirk Van Rooy, Frank Vansteenkiste, Franky |
| description | Background
The purpose of this retrospective analysis was to determine if a short course of prophylactic proton pump inhibitor (PPI) therapy can prevent stomal ulceration after laparoscopic Roux-en-Y gastric bypass (LRYGBP).
Methods
Four hundred forty-nine consecutive patients who underwent LRYGBP and had a minimum of 6 months follow-up were included. Patients were categorized in two groups: patients with
Helicobacter pylori
at preoperative endoscopy (HP group) and patients without
H. pylori
(non-HP group). All patients in the HP group were medically treated prior to surgery. In both groups, almost half of the patients received low-dose proton pump inhibitors (omeprazole 20 mg daily) for 1 month following LRYGBP.
Results
The incidence of stomal ulceration in the HP group was not statistically different from the incidence in the non-HP group (7/86, 8.14% vs. 41/363, 11.29%;
p
= 0.559). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the non-HP group, there was no significant reduction in development of stomal ulceration (18/169, 10.65% vs. 23/194, 11.86%;
p
= 0.743). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the HP group, there is a significant reduction in development of stomal ulceration (0/41, 0% vs. 7/45, 15.56%;
p
= 0.0123).
Conclusion
Development of stomal ulceration in patients tested positive for
H. pylori
prior to LRYGBP can be prevented by prophylactic low-dose PPI therapy following surgery. |
| doi_str_mv | 10.1007/s11695-009-0062-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733864595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733864595</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-4ac361f978582a42328d047f41736b3056bcba588e5a32f81513346774c1eb5c3</originalsourceid><addsrcrecordid>eNp1UU9rFDEUD6LYtfoBvEjw4in6kkwmmZPURWthwWLbg6eQyWbcKTOTMcno7rfwI_vKVgXBQwj8_r2X_Ah5zuE1B9BvMud1oxhAg6cWbP-ArLgGw6AS5iFZQVMDM42QJ-RJzrcAgtdCPCYnAkAZaPSK_Fy7iTp6tYup0HVcUg40dvQyxXl3GJwvvaeb-INtIxKIljjRy2Wc6cW069u-xESvdyG5-YBs-B6mQq9KHN1AbwaPeOnRcNaVkOjGzS7F7OOMmZ_jsmdhYl_oucslIfLuMLuc3z4ljzo35PDs_j4lNx_eX68_ss2n84v12YZ5qaGwynlZ867RRhnhKiGF2UKlu4prWbcSVN361iljgnJSdIYrLmVVa115Hlrl5Sl5dcydU_y2hFzs2GcfhsFNIS7ZailNXalGofLlP8pb_KcJl7MC53KuTIMifhR5fGJOobNz6keXDpaDvSvLHsuyWJa9K8vu0fPiPnhpx7D94_jdDgrEUZCRmr6G9Hfy_1N_AXAwn7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223211589</pqid></control><display><type>article</type><title>Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>André D’Hondt, Mathieu ; Pottel, Hans ; Devriendt, Dirk ; Van Rooy, Frank ; Vansteenkiste, Franky</creator><creatorcontrib>André D’Hondt, Mathieu ; Pottel, Hans ; Devriendt, Dirk ; Van Rooy, Frank ; Vansteenkiste, Franky</creatorcontrib><description>Background
The purpose of this retrospective analysis was to determine if a short course of prophylactic proton pump inhibitor (PPI) therapy can prevent stomal ulceration after laparoscopic Roux-en-Y gastric bypass (LRYGBP).
Methods
Four hundred forty-nine consecutive patients who underwent LRYGBP and had a minimum of 6 months follow-up were included. Patients were categorized in two groups: patients with
Helicobacter pylori
at preoperative endoscopy (HP group) and patients without
H. pylori
(non-HP group). All patients in the HP group were medically treated prior to surgery. In both groups, almost half of the patients received low-dose proton pump inhibitors (omeprazole 20 mg daily) for 1 month following LRYGBP.
Results
The incidence of stomal ulceration in the HP group was not statistically different from the incidence in the non-HP group (7/86, 8.14% vs. 41/363, 11.29%;
p
= 0.559). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the non-HP group, there was no significant reduction in development of stomal ulceration (18/169, 10.65% vs. 23/194, 11.86%;
p
= 0.743). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the HP group, there is a significant reduction in development of stomal ulceration (0/41, 0% vs. 7/45, 15.56%;
p
= 0.0123).
Conclusion
Development of stomal ulceration in patients tested positive for
H. pylori
prior to LRYGBP can be prevented by prophylactic low-dose PPI therapy following surgery.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-009-0062-x</identifier><identifier>PMID: 20058097</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Aged ; Bacteria ; Female ; Gastric Bypass - methods ; Gastrointestinal surgery ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Humans ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity, Morbid - surgery ; Other ; Preventive medicine ; Proton Pump Inhibitors - therapeutic use ; Retrospective Studies ; Stomach Ulcer - epidemiology ; Stomach Ulcer - prevention & control ; Surgery ; Treatment Outcome ; Ulcers ; Young Adult</subject><ispartof>Obesity surgery, 2010-05, Vol.20 (5), p.595-599</ispartof><rights>Springer Science + Business Media, LLC 2009</rights><rights>Springer Science + Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-4ac361f978582a42328d047f41736b3056bcba588e5a32f81513346774c1eb5c3</citedby><cites>FETCH-LOGICAL-c370t-4ac361f978582a42328d047f41736b3056bcba588e5a32f81513346774c1eb5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-009-0062-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-009-0062-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20058097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>André D’Hondt, Mathieu</creatorcontrib><creatorcontrib>Pottel, Hans</creatorcontrib><creatorcontrib>Devriendt, Dirk</creatorcontrib><creatorcontrib>Van Rooy, Frank</creatorcontrib><creatorcontrib>Vansteenkiste, Franky</creatorcontrib><title>Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
The purpose of this retrospective analysis was to determine if a short course of prophylactic proton pump inhibitor (PPI) therapy can prevent stomal ulceration after laparoscopic Roux-en-Y gastric bypass (LRYGBP).
Methods
Four hundred forty-nine consecutive patients who underwent LRYGBP and had a minimum of 6 months follow-up were included. Patients were categorized in two groups: patients with
Helicobacter pylori
at preoperative endoscopy (HP group) and patients without
H. pylori
(non-HP group). All patients in the HP group were medically treated prior to surgery. In both groups, almost half of the patients received low-dose proton pump inhibitors (omeprazole 20 mg daily) for 1 month following LRYGBP.
Results
The incidence of stomal ulceration in the HP group was not statistically different from the incidence in the non-HP group (7/86, 8.14% vs. 41/363, 11.29%;
p
= 0.559). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the non-HP group, there was no significant reduction in development of stomal ulceration (18/169, 10.65% vs. 23/194, 11.86%;
p
= 0.743). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the HP group, there is a significant reduction in development of stomal ulceration (0/41, 0% vs. 7/45, 15.56%;
p
= 0.0123).
Conclusion
Development of stomal ulceration in patients tested positive for
H. pylori
prior to LRYGBP can be prevented by prophylactic low-dose PPI therapy following surgery.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Bacteria</subject><subject>Female</subject><subject>Gastric Bypass - methods</subject><subject>Gastrointestinal surgery</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity, Morbid - surgery</subject><subject>Other</subject><subject>Preventive medicine</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Stomach Ulcer - epidemiology</subject><subject>Stomach Ulcer - prevention & control</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Ulcers</subject><subject>Young Adult</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UU9rFDEUD6LYtfoBvEjw4in6kkwmmZPURWthwWLbg6eQyWbcKTOTMcno7rfwI_vKVgXBQwj8_r2X_Ah5zuE1B9BvMud1oxhAg6cWbP-ArLgGw6AS5iFZQVMDM42QJ-RJzrcAgtdCPCYnAkAZaPSK_Fy7iTp6tYup0HVcUg40dvQyxXl3GJwvvaeb-INtIxKIljjRy2Wc6cW069u-xESvdyG5-YBs-B6mQq9KHN1AbwaPeOnRcNaVkOjGzS7F7OOMmZ_jsmdhYl_oucslIfLuMLuc3z4ljzo35PDs_j4lNx_eX68_ss2n84v12YZ5qaGwynlZ867RRhnhKiGF2UKlu4prWbcSVN361iljgnJSdIYrLmVVa115Hlrl5Sl5dcydU_y2hFzs2GcfhsFNIS7ZailNXalGofLlP8pb_KcJl7MC53KuTIMifhR5fGJOobNz6keXDpaDvSvLHsuyWJa9K8vu0fPiPnhpx7D94_jdDgrEUZCRmr6G9Hfy_1N_AXAwn7A</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>André D’Hondt, Mathieu</creator><creator>Pottel, Hans</creator><creator>Devriendt, Dirk</creator><creator>Van Rooy, Frank</creator><creator>Vansteenkiste, Franky</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?</title><author>André D’Hondt, Mathieu ; Pottel, Hans ; Devriendt, Dirk ; Van Rooy, Frank ; Vansteenkiste, Franky</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-4ac361f978582a42328d047f41736b3056bcba588e5a32f81513346774c1eb5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Bacteria</topic><topic>Female</topic><topic>Gastric Bypass - methods</topic><topic>Gastrointestinal surgery</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity, Morbid - surgery</topic><topic>Other</topic><topic>Preventive medicine</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Stomach Ulcer - epidemiology</topic><topic>Stomach Ulcer - prevention & control</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Ulcers</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>André D’Hondt, Mathieu</creatorcontrib><creatorcontrib>Pottel, Hans</creatorcontrib><creatorcontrib>Devriendt, Dirk</creatorcontrib><creatorcontrib>Van Rooy, Frank</creatorcontrib><creatorcontrib>Vansteenkiste, Franky</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>André D’Hondt, Mathieu</au><au>Pottel, Hans</au><au>Devriendt, Dirk</au><au>Van Rooy, Frank</au><au>Vansteenkiste, Franky</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>20</volume><issue>5</issue><spage>595</spage><epage>599</epage><pages>595-599</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
The purpose of this retrospective analysis was to determine if a short course of prophylactic proton pump inhibitor (PPI) therapy can prevent stomal ulceration after laparoscopic Roux-en-Y gastric bypass (LRYGBP).
Methods
Four hundred forty-nine consecutive patients who underwent LRYGBP and had a minimum of 6 months follow-up were included. Patients were categorized in two groups: patients with
Helicobacter pylori
at preoperative endoscopy (HP group) and patients without
H. pylori
(non-HP group). All patients in the HP group were medically treated prior to surgery. In both groups, almost half of the patients received low-dose proton pump inhibitors (omeprazole 20 mg daily) for 1 month following LRYGBP.
Results
The incidence of stomal ulceration in the HP group was not statistically different from the incidence in the non-HP group (7/86, 8.14% vs. 41/363, 11.29%;
p
= 0.559). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the non-HP group, there was no significant reduction in development of stomal ulceration (18/169, 10.65% vs. 23/194, 11.86%;
p
= 0.743). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the HP group, there is a significant reduction in development of stomal ulceration (0/41, 0% vs. 7/45, 15.56%;
p
= 0.0123).
Conclusion
Development of stomal ulceration in patients tested positive for
H. pylori
prior to LRYGBP can be prevented by prophylactic low-dose PPI therapy following surgery.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20058097</pmid><doi>10.1007/s11695-009-0062-x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-8923 |
| ispartof | Obesity surgery, 2010-05, Vol.20 (5), p.595-599 |
| issn | 0960-8923 1708-0428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733864595 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Aged Bacteria Female Gastric Bypass - methods Gastrointestinal surgery Helicobacter Infections - drug therapy Helicobacter pylori Humans Laparoscopy - methods Male Medicine Medicine & Public Health Middle Aged Obesity, Morbid - surgery Other Preventive medicine Proton Pump Inhibitors - therapeutic use Retrospective Studies Stomach Ulcer - epidemiology Stomach Ulcer - prevention & control Surgery Treatment Outcome Ulcers Young Adult |
| title | Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass? |
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