Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma
The aim of this study was to analyze the immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 in colorectal adenocarcinoma, and to correlate this with clinicopathological prognostic factors. Formalin-fixed paraffin-embedded tumor tissue from 82 patients was analyzed by means of immu...
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| Veröffentlicht in: | The International journal of biological markers 2009-07, Vol.24 (3), p.156-164 |
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| container_title | The International journal of biological markers |
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| creator | NUNES, Benicio L. B. B. P JUCA, Mario J GOMES, Edmundo G. A MENEZES, Hunaldo L COSTA, Henrique O MATOS, Delcio SAAD, Sarhan S |
| description | The aim of this study was to analyze the immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 in colorectal adenocarcinoma, and to correlate this with clinicopathological prognostic factors.
Formalin-fixed paraffin-embedded tumor tissue from 82 patients was analyzed by means of immunohistochemistry, using the streptavidin-biotin method and the tissue microarray technique. Protein tissue expression was correlated with the variables of the degree of cell differentiation, stage, relapse-free survival, recurrence, survival, and specific mortality.
All of the tumors were positive for metalloproteinase-1, while 50 (61%) were positive for metalloproteinase-7, and 32 (39%) were negative for the latter. For p53, 70 (85.4%) of the tumors were positive and 12 (14.6%) were negative. Correlation of the marker expressions separately and in conjunction did not produce any statistically significant data.
The immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 did not correlate with recurrence, mortality, relapse-free survival, survival, degree of cell differentiation, or staging of colorectal cancer. |
| doi_str_mv | 10.1177/172460080902400305 |
| format | Article |
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Formalin-fixed paraffin-embedded tumor tissue from 82 patients was analyzed by means of immunohistochemistry, using the streptavidin-biotin method and the tissue microarray technique. Protein tissue expression was correlated with the variables of the degree of cell differentiation, stage, relapse-free survival, recurrence, survival, and specific mortality.
All of the tumors were positive for metalloproteinase-1, while 50 (61%) were positive for metalloproteinase-7, and 32 (39%) were negative for the latter. For p53, 70 (85.4%) of the tumors were positive and 12 (14.6%) were negative. Correlation of the marker expressions separately and in conjunction did not produce any statistically significant data.
The immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 did not correlate with recurrence, mortality, relapse-free survival, survival, degree of cell differentiation, or staging of colorectal cancer.</description><identifier>ISSN: 0393-6155</identifier><identifier>EISSN: 1724-6008</identifier><identifier>DOI: 10.1177/172460080902400305</identifier><identifier>PMID: 19787626</identifier><language>eng</language><publisher>Milano: Wichtig</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Colonic Neoplasms - genetics ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - mortality ; Colonic Neoplasms - pathology ; Colonic Neoplasms - surgery ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 7 - metabolism ; Medical sciences ; Middle Aged ; Molecular biophysics ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Rectal Neoplasms - genetics ; Rectal Neoplasms - metabolism ; Rectal Neoplasms - mortality ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Survival Analysis ; Survivors ; Tumor Suppressor Protein p53 - metabolism ; Young Adult</subject><ispartof>The International journal of biological markers, 2009-07, Vol.24 (3), p.156-164</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c306t-c024b5a42d65b5ed80d616d9c6d5220ed0f0f83874b41a81416e0237aa714ce83</citedby><cites>FETCH-LOGICAL-c306t-c024b5a42d65b5ed80d616d9c6d5220ed0f0f83874b41a81416e0237aa714ce83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22015305$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19787626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NUNES, Benicio L. B. B. P</creatorcontrib><creatorcontrib>JUCA, Mario J</creatorcontrib><creatorcontrib>GOMES, Edmundo G. A</creatorcontrib><creatorcontrib>MENEZES, Hunaldo L</creatorcontrib><creatorcontrib>COSTA, Henrique O</creatorcontrib><creatorcontrib>MATOS, Delcio</creatorcontrib><creatorcontrib>SAAD, Sarhan S</creatorcontrib><title>Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma</title><title>The International journal of biological markers</title><addtitle>Int J Biol Markers</addtitle><description>The aim of this study was to analyze the immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 in colorectal adenocarcinoma, and to correlate this with clinicopathological prognostic factors.
Formalin-fixed paraffin-embedded tumor tissue from 82 patients was analyzed by means of immunohistochemistry, using the streptavidin-biotin method and the tissue microarray technique. Protein tissue expression was correlated with the variables of the degree of cell differentiation, stage, relapse-free survival, recurrence, survival, and specific mortality.
All of the tumors were positive for metalloproteinase-1, while 50 (61%) were positive for metalloproteinase-7, and 32 (39%) were negative for the latter. For p53, 70 (85.4%) of the tumors were positive and 12 (14.6%) were negative. Correlation of the marker expressions separately and in conjunction did not produce any statistically significant data.
The immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 did not correlate with recurrence, mortality, relapse-free survival, survival, degree of cell differentiation, or staging of colorectal cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - surgery</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 7 - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular biophysics</subject><subject>Neoplasm Staging</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Rectal Neoplasms - genetics</subject><subject>Rectal Neoplasms - metabolism</subject><subject>Rectal Neoplasms - mortality</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - surgery</subject><subject>Survival Analysis</subject><subject>Survivors</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Young Adult</subject><issn>0393-6155</issn><issn>1724-6008</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUcFu1DAUtBCIbgs_wAH5grg05dlO7OwRVVCQinop5-it89I1cuxge0X5nP4pDl3BoSdL45l5780w9kbAhRDGfBBGthqghy3IFkBB94xtVrBZ0edsA2qrGi267oSd5vwDQAow-iU7EVvTGy31hj18o4LexyXFQi5gpkac8_kJaM45hpEvneJung8h0v2SKGcXw9-PsieXuI0pkceyor9c2XPrXXA2Llj20cc7Z9Hz6noXYi7O8gltiSlzF6rUx0S2zuU4UogWk3UhzviKvZjQZ3p9fM_Y98-fbi-_NNc3V18vP143VoEuja0Z7Dps5ai7XUdjD6MWetxaPXZSAo0wwdSr3rS7VmAvWqEJpDKIRrSWenXG3j_61v1-HiiXYXbZkvcYKB7yYJTqtawxV6Z8ZNoUc040DUtyM6bfg4BhbWZ42kwVvT3aH3Yzjf8lxyoq4d2RgLnGNCUM1uV_vHqD6FajP7UAmXI</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>NUNES, Benicio L. B. B. P</creator><creator>JUCA, Mario J</creator><creator>GOMES, Edmundo G. A</creator><creator>MENEZES, Hunaldo L</creator><creator>COSTA, Henrique O</creator><creator>MATOS, Delcio</creator><creator>SAAD, Sarhan S</creator><general>Wichtig</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma</title><author>NUNES, Benicio L. B. B. P ; JUCA, Mario J ; GOMES, Edmundo G. 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Psychology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 7 - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular biophysics</topic><topic>Neoplasm Staging</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Rectal Neoplasms - genetics</topic><topic>Rectal Neoplasms - metabolism</topic><topic>Rectal Neoplasms - mortality</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - surgery</topic><topic>Survival Analysis</topic><topic>Survivors</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NUNES, Benicio L. B. B. P</creatorcontrib><creatorcontrib>JUCA, Mario J</creatorcontrib><creatorcontrib>GOMES, Edmundo G. A</creatorcontrib><creatorcontrib>MENEZES, Hunaldo L</creatorcontrib><creatorcontrib>COSTA, Henrique O</creatorcontrib><creatorcontrib>MATOS, Delcio</creatorcontrib><creatorcontrib>SAAD, Sarhan S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of biological markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NUNES, Benicio L. B. B. P</au><au>JUCA, Mario J</au><au>GOMES, Edmundo G. A</au><au>MENEZES, Hunaldo L</au><au>COSTA, Henrique O</au><au>MATOS, Delcio</au><au>SAAD, Sarhan S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma</atitle><jtitle>The International journal of biological markers</jtitle><addtitle>Int J Biol Markers</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>24</volume><issue>3</issue><spage>156</spage><epage>164</epage><pages>156-164</pages><issn>0393-6155</issn><eissn>1724-6008</eissn><abstract>The aim of this study was to analyze the immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 in colorectal adenocarcinoma, and to correlate this with clinicopathological prognostic factors.
Formalin-fixed paraffin-embedded tumor tissue from 82 patients was analyzed by means of immunohistochemistry, using the streptavidin-biotin method and the tissue microarray technique. Protein tissue expression was correlated with the variables of the degree of cell differentiation, stage, relapse-free survival, recurrence, survival, and specific mortality.
All of the tumors were positive for metalloproteinase-1, while 50 (61%) were positive for metalloproteinase-7, and 32 (39%) were negative for the latter. For p53, 70 (85.4%) of the tumors were positive and 12 (14.6%) were negative. Correlation of the marker expressions separately and in conjunction did not produce any statistically significant data.
The immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 did not correlate with recurrence, mortality, relapse-free survival, survival, degree of cell differentiation, or staging of colorectal cancer.</abstract><cop>Milano</cop><pub>Wichtig</pub><pmid>19787626</pmid><doi>10.1177/172460080902400305</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry Biological and medical sciences Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - surgery Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 7 - metabolism Medical sciences Middle Aged Molecular biophysics Neoplasm Staging Oligonucleotide Array Sequence Analysis Rectal Neoplasms - genetics Rectal Neoplasms - metabolism Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - surgery Survival Analysis Survivors Tumor Suppressor Protein p53 - metabolism Young Adult |
| title | Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma |
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