Association of Caveolin-1 Gene Polymorphism With Kidney Transplant Fibrosis and Allograft Failure

CONTEXT Caveolin-1 (CAV1) is an inhibitor of tissue fibrosis. OBJECTIVE To study the association of CAV1 gene variation with kidney transplant outcome, using kidney transplantation as a model of accelerated fibrosis. DESIGN, SETTING, AND PATIENTS Candidate gene association and validation study. Geno...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2010-04, Vol.303 (13), p.1282-1287
Hauptverfasser:	Moore, Jason, McKnight, Amy Jayne, Simmonds, Matthew J, Courtney, Aisling E, Hanvesakul, Rajesh, Brand, Oliver J, Briggs, David, Ball, Simon, Cockwell, Paul, Patterson, Christopher C, Maxwell, Alexander P, Gough, Stephen C. L, Borrows, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Caveolin 1 - genetics Cohort Studies England Female Fibrosis General aspects Genetic Predisposition to Disease Genotype Genotype & phenotype Humans Kidney - pathology Kidney - physiopathology Kidney Transplantation - adverse effects Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Polymorphism, Genetic Renal failure Skin & tissue grafts Tissue Donors Transplantation, Homologous Transplants & implants Treatment Failure
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