Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells

Objectives To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in cell cycle, proliferation, apoptosis, angiogenesis, and cellular resistance to c...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 2010-04, Vol.75 (4), p.793-798
Hauptverfasser:	Goktas, Serdar, Baran, Yusuf, Ural, Ali U, Yazici, Sertac, Aydur, Emin, Basal, Seref, Avcu, Ferit, Pekel, Aysel, Dirican, Bahar, Beyzadeoglu, Murat
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - metabolism Boronic Acids - therapeutic use Bortezomib Combined Modality Therapy Humans Male Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - radiotherapy Protease Inhibitors - therapeutic use Proteasome Inhibitors Pyrazines - therapeutic use Radiation-Sensitizing Agents - therapeutic use Tumor Cells, Cultured Urology
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