Synthesis of Orthogonally Protected (R)- and (S)-2-Methylcysteine via an Enzymatic Desymmeterization and Curtius Rearrangement

A synthesis of differentially protected (R)- and (S)-2-methylcysteines is described. Monomethylation of dimethylmalonate followed by alkylation with tert-butylchloromethyl sulfide gave an achiral diester. Desymmeterization by selective hydrolysis of one ester with pig-liver esterase gave the acid in...

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Veröffentlicht in:	Journal of organic chemistry 2003-06, Vol.68 (13), p.5403-5406
1. Verfasser:	Kedrowski, Brant L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Cysteine - analogs & derivatives Cysteine - analysis Cysteine - chemical synthesis Fundamental and applied biological sciences. Psychology Hydrolysis Liver - enzymology Methods. Procedures. Technologies Molecular Structure Stereoisomerism Structure-Activity Relationship Swine
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