Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging

Objective To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. Methods All PCOS cases ( n  = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for P...

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Veröffentlicht in:European radiology 2010-05, Vol.20 (5), p.1207-1213
Hauptverfasser: Barber, Thomas M., Alvey, Christopher, Greenslade, Tessa, Gooding, Mark, Barber, Debbie, Smith, Rachel, Marland, Anne, Wass, John A. H., Child, Tim, McCarthy, Mark I., Franks, Stephen, Golding, Stephen J.
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container_end_page 1213
container_issue 5
container_start_page 1207
container_title European radiology
container_volume 20
creator Barber, Thomas M.
Alvey, Christopher
Greenslade, Tessa
Gooding, Mark
Barber, Debbie
Smith, Rachel
Marland, Anne
Wass, John A. H.
Child, Tim
McCarthy, Mark I.
Franks, Stephen
Golding, Stephen J.
description Objective To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. Methods All PCOS cases ( n  = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women ( n  = 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm 3 . Results Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted P  = 1.3 × 10 −16 ; calculated ovarian volume 8.8 cm 3 [5.0, 15.5] vs 5.1 cm 3 [2.5, 10.3], unadjusted P  = 3.0 × 10 –7 ; peripheral follicle location in 55% vs 18% of ovaries, P  = 7.9 × 10 –6 ; visible central ovarian stroma in 61% vs 24% of ovaries, P  = 2.3 × 10 –5 ). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively. Conclusion Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.
doi_str_mv 10.1007/s00330-009-1643-8
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H. ; Child, Tim ; McCarthy, Mark I. ; Franks, Stephen ; Golding, Stephen J.</creator><creatorcontrib>Barber, Thomas M. ; Alvey, Christopher ; Greenslade, Tessa ; Gooding, Mark ; Barber, Debbie ; Smith, Rachel ; Marland, Anne ; Wass, John A. H. ; Child, Tim ; McCarthy, Mark I. ; Franks, Stephen ; Golding, Stephen J.</creatorcontrib><description>Objective To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. Methods All PCOS cases ( n  = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women ( n  = 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm 3 . Results Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted P  = 1.3 × 10 −16 ; calculated ovarian volume 8.8 cm 3 [5.0, 15.5] vs 5.1 cm 3 [2.5, 10.3], unadjusted P  = 3.0 × 10 –7 ; peripheral follicle location in 55% vs 18% of ovaries, P  = 7.9 × 10 –6 ; visible central ovarian stroma in 61% vs 24% of ovaries, P  = 2.3 × 10 –5 ). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively. Conclusion Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-009-1643-8</identifier><identifier>PMID: 19890641</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Biomarkers - analysis ; Case-Control Studies ; Diabetes ; Diagnostic Radiology ; Endocrinology ; Female ; Follicles ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine &amp; Public Health ; Menstruation ; Metabolism ; Middle Aged ; Morphology ; Neuroradiology ; Ovarian Follicle - pathology ; Ovaries ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - pathology ; Premenopause ; Radiology ; Ultrasonic imaging ; Ultrasound</subject><ispartof>European radiology, 2010-05, Vol.20 (5), p.1207-1213</ispartof><rights>European Society of Radiology 2009</rights><rights>European Society of Radiology 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-390b8d0b3265286ae61680441ed37d13ca3e3fe66c53ee2672fc4c7f009cc0d83</citedby><cites>FETCH-LOGICAL-c370t-390b8d0b3265286ae61680441ed37d13ca3e3fe66c53ee2672fc4c7f009cc0d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-009-1643-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-009-1643-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19890641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barber, Thomas M.</creatorcontrib><creatorcontrib>Alvey, Christopher</creatorcontrib><creatorcontrib>Greenslade, Tessa</creatorcontrib><creatorcontrib>Gooding, Mark</creatorcontrib><creatorcontrib>Barber, Debbie</creatorcontrib><creatorcontrib>Smith, Rachel</creatorcontrib><creatorcontrib>Marland, Anne</creatorcontrib><creatorcontrib>Wass, John A. H.</creatorcontrib><creatorcontrib>Child, Tim</creatorcontrib><creatorcontrib>McCarthy, Mark I.</creatorcontrib><creatorcontrib>Franks, Stephen</creatorcontrib><creatorcontrib>Golding, Stephen J.</creatorcontrib><title>Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. Methods All PCOS cases ( n  = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women ( n  = 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm 3 . Results Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted P  = 1.3 × 10 −16 ; calculated ovarian volume 8.8 cm 3 [5.0, 15.5] vs 5.1 cm 3 [2.5, 10.3], unadjusted P  = 3.0 × 10 –7 ; peripheral follicle location in 55% vs 18% of ovaries, P  = 7.9 × 10 –6 ; visible central ovarian stroma in 61% vs 24% of ovaries, P  = 2.3 × 10 –5 ). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively. 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H.</au><au>Child, Tim</au><au>McCarthy, Mark I.</au><au>Franks, Stephen</au><au>Golding, Stephen J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>20</volume><issue>5</issue><spage>1207</spage><epage>1213</epage><pages>1207-1213</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. Methods All PCOS cases ( n  = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women ( n  = 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample t tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm 3 . Results Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted P  = 1.3 × 10 −16 ; calculated ovarian volume 8.8 cm 3 [5.0, 15.5] vs 5.1 cm 3 [2.5, 10.3], unadjusted P  = 3.0 × 10 –7 ; peripheral follicle location in 55% vs 18% of ovaries, P  = 7.9 × 10 –6 ; visible central ovarian stroma in 61% vs 24% of ovaries, P  = 2.3 × 10 –5 ). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively. Conclusion Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19890641</pmid><doi>10.1007/s00330-009-1643-8</doi><tpages>7</tpages></addata></record>
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subjects Adolescent
Adult
Biomarkers - analysis
Case-Control Studies
Diabetes
Diagnostic Radiology
Endocrinology
Female
Follicles
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Menstruation
Metabolism
Middle Aged
Morphology
Neuroradiology
Ovarian Follicle - pathology
Ovaries
Polycystic ovary syndrome
Polycystic Ovary Syndrome - pathology
Premenopause
Radiology
Ultrasonic imaging
Ultrasound
title Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging
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