Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging
Objective To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls. Methods All PCOS cases ( n = 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for P...
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description | Objective
To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls.
Methods
All PCOS cases (
n
= 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (
n
= 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample
t
tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm
3
.
Results
Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted
P
= 1.3 × 10
−16
; calculated ovarian volume 8.8 cm
3
[5.0, 15.5] vs 5.1 cm
3
[2.5, 10.3], unadjusted
P
= 3.0 × 10
–7
; peripheral follicle location in 55% vs 18% of ovaries,
P
= 7.9 × 10
–6
; visible central ovarian stroma in 61% vs 24% of ovaries,
P
= 2.3 × 10
–5
). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively.
Conclusion
Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS. |
doi_str_mv | 10.1007/s00330-009-1643-8 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733859698</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2005428431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-390b8d0b3265286ae61680441ed37d13ca3e3fe66c53ee2672fc4c7f009cc0d83</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVpSbZJfkAvRfTSk9vRx8pSbiH0CwLtITkLrTzeKtjSVrID_veRuwuBQk8DM8-88_ES8o7BJwbQfi4AQkADYBqmpGj0K7JhUvCGgZavyQaM0E1rjDwnb0t5hAoy2Z6Rc2a0ASXZhoRfbpowx0JTT9OTy8FFOqZ8-J2GtF9oiPSQhsUvZQr-L7DQssQupxGvqaNlmruFzlMYQglxT0e3j7iiGUuKLnqkoeZq6ZK86d1Q8OoUL8jD1y_3t9-bu5_fftze3DVetDA1wsBOd7ATXG25Vg4VUxqkZNiJtmPCO4GiR6X8ViBy1fLeS9_29TbvodPignw86h5y-jNjmewYisdhcBHTXGwrhN4aZVbywz_kY5pzrMtZzrThcsuhQuwI-ZxKydjbQ64X5cUysKsL9uiCrQvY1QW7Cr8_Cc-7EbuXjtPbK8CPQKmluMf8Mvn_qs-WeJN9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218924520</pqid></control><display><type>article</type><title>Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Barber, Thomas M. ; Alvey, Christopher ; Greenslade, Tessa ; Gooding, Mark ; Barber, Debbie ; Smith, Rachel ; Marland, Anne ; Wass, John A. H. ; Child, Tim ; McCarthy, Mark I. ; Franks, Stephen ; Golding, Stephen J.</creator><creatorcontrib>Barber, Thomas M. ; Alvey, Christopher ; Greenslade, Tessa ; Gooding, Mark ; Barber, Debbie ; Smith, Rachel ; Marland, Anne ; Wass, John A. H. ; Child, Tim ; McCarthy, Mark I. ; Franks, Stephen ; Golding, Stephen J.</creatorcontrib><description>Objective
To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls.
Methods
All PCOS cases (
n
= 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (
n
= 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample
t
tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm
3
.
Results
Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted
P
= 1.3 × 10
−16
; calculated ovarian volume 8.8 cm
3
[5.0, 15.5] vs 5.1 cm
3
[2.5, 10.3], unadjusted
P
= 3.0 × 10
–7
; peripheral follicle location in 55% vs 18% of ovaries,
P
= 7.9 × 10
–6
; visible central ovarian stroma in 61% vs 24% of ovaries,
P
= 2.3 × 10
–5
). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively.
Conclusion
Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-009-1643-8</identifier><identifier>PMID: 19890641</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Biomarkers - analysis ; Case-Control Studies ; Diabetes ; Diagnostic Radiology ; Endocrinology ; Female ; Follicles ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine & Public Health ; Menstruation ; Metabolism ; Middle Aged ; Morphology ; Neuroradiology ; Ovarian Follicle - pathology ; Ovaries ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - pathology ; Premenopause ; Radiology ; Ultrasonic imaging ; Ultrasound</subject><ispartof>European radiology, 2010-05, Vol.20 (5), p.1207-1213</ispartof><rights>European Society of Radiology 2009</rights><rights>European Society of Radiology 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-390b8d0b3265286ae61680441ed37d13ca3e3fe66c53ee2672fc4c7f009cc0d83</citedby><cites>FETCH-LOGICAL-c370t-390b8d0b3265286ae61680441ed37d13ca3e3fe66c53ee2672fc4c7f009cc0d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-009-1643-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-009-1643-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19890641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barber, Thomas M.</creatorcontrib><creatorcontrib>Alvey, Christopher</creatorcontrib><creatorcontrib>Greenslade, Tessa</creatorcontrib><creatorcontrib>Gooding, Mark</creatorcontrib><creatorcontrib>Barber, Debbie</creatorcontrib><creatorcontrib>Smith, Rachel</creatorcontrib><creatorcontrib>Marland, Anne</creatorcontrib><creatorcontrib>Wass, John A. H.</creatorcontrib><creatorcontrib>Child, Tim</creatorcontrib><creatorcontrib>McCarthy, Mark I.</creatorcontrib><creatorcontrib>Franks, Stephen</creatorcontrib><creatorcontrib>Golding, Stephen J.</creatorcontrib><title>Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls.
Methods
All PCOS cases (
n
= 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (
n
= 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample
t
tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm
3
.
Results
Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted
P
= 1.3 × 10
−16
; calculated ovarian volume 8.8 cm
3
[5.0, 15.5] vs 5.1 cm
3
[2.5, 10.3], unadjusted
P
= 3.0 × 10
–7
; peripheral follicle location in 55% vs 18% of ovaries,
P
= 7.9 × 10
–6
; visible central ovarian stroma in 61% vs 24% of ovaries,
P
= 2.3 × 10
–5
). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively.
Conclusion
Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diagnostic Radiology</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Follicles</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menstruation</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Neuroradiology</subject><subject>Ovarian Follicle - pathology</subject><subject>Ovaries</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>Premenopause</subject><subject>Radiology</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1r3DAQhkVpSbZJfkAvRfTSk9vRx8pSbiH0CwLtITkLrTzeKtjSVrID_veRuwuBQk8DM8-88_ES8o7BJwbQfi4AQkADYBqmpGj0K7JhUvCGgZavyQaM0E1rjDwnb0t5hAoy2Z6Rc2a0ASXZhoRfbpowx0JTT9OTy8FFOqZ8-J2GtF9oiPSQhsUvZQr-L7DQssQupxGvqaNlmruFzlMYQglxT0e3j7iiGUuKLnqkoeZq6ZK86d1Q8OoUL8jD1y_3t9-bu5_fftze3DVetDA1wsBOd7ATXG25Vg4VUxqkZNiJtmPCO4GiR6X8ViBy1fLeS9_29TbvodPignw86h5y-jNjmewYisdhcBHTXGwrhN4aZVbywz_kY5pzrMtZzrThcsuhQuwI-ZxKydjbQ64X5cUysKsL9uiCrQvY1QW7Cr8_Cc-7EbuXjtPbK8CPQKmluMf8Mvn_qs-WeJN9</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Barber, Thomas M.</creator><creator>Alvey, Christopher</creator><creator>Greenslade, Tessa</creator><creator>Gooding, Mark</creator><creator>Barber, Debbie</creator><creator>Smith, Rachel</creator><creator>Marland, Anne</creator><creator>Wass, John A. H.</creator><creator>Child, Tim</creator><creator>McCarthy, Mark I.</creator><creator>Franks, Stephen</creator><creator>Golding, Stephen J.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging</title><author>Barber, Thomas M. ; Alvey, Christopher ; Greenslade, Tessa ; Gooding, Mark ; Barber, Debbie ; Smith, Rachel ; Marland, Anne ; Wass, John A. H. ; Child, Tim ; McCarthy, Mark I. ; Franks, Stephen ; Golding, Stephen J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-390b8d0b3265286ae61680441ed37d13ca3e3fe66c53ee2672fc4c7f009cc0d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diagnostic Radiology</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Follicles</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menstruation</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Neuroradiology</topic><topic>Ovarian Follicle - pathology</topic><topic>Ovaries</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Premenopause</topic><topic>Radiology</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barber, Thomas M.</creatorcontrib><creatorcontrib>Alvey, Christopher</creatorcontrib><creatorcontrib>Greenslade, Tessa</creatorcontrib><creatorcontrib>Gooding, Mark</creatorcontrib><creatorcontrib>Barber, Debbie</creatorcontrib><creatorcontrib>Smith, Rachel</creatorcontrib><creatorcontrib>Marland, Anne</creatorcontrib><creatorcontrib>Wass, John A. H.</creatorcontrib><creatorcontrib>Child, Tim</creatorcontrib><creatorcontrib>McCarthy, Mark I.</creatorcontrib><creatorcontrib>Franks, Stephen</creatorcontrib><creatorcontrib>Golding, Stephen J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barber, Thomas M.</au><au>Alvey, Christopher</au><au>Greenslade, Tessa</au><au>Gooding, Mark</au><au>Barber, Debbie</au><au>Smith, Rachel</au><au>Marland, Anne</au><au>Wass, John A. H.</au><au>Child, Tim</au><au>McCarthy, Mark I.</au><au>Franks, Stephen</au><au>Golding, Stephen J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>20</volume><issue>5</issue><spage>1207</spage><epage>1213</epage><pages>1207-1213</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
To evaluate and compare MRI-based ovarian morphology in groups of women with polycystic ovary syndrome (PCOS) and controls.
Methods
All PCOS cases (
n
= 44) had oligo-amenorrhoea and hyperandrogenism irrespective of ovarian morphology, and fulfilled NIH/Rotterdam diagnostic criteria for PCOS. All control women (
n
= 40) had normal menses and normoandrogenaemia. All subjects were of white British/Irish origin and pre-menopausal. Group comparisons were based on independent-sample
t
tests. Polycystic ovarian morphology was defined by at least 12 follicles 2–9 mm in diameter and/or an ovarian volume greater than 10 cm
3
.
Results
Ovarian morphology differed significantly in PCOS cases and controls (follicle number geometric mean [SD range] 18.6 [9.9, 35.0] vs 6.6 [3.1, 14.2], unadjusted
P
= 1.3 × 10
−16
; calculated ovarian volume 8.8 cm
3
[5.0, 15.5] vs 5.1 cm
3
[2.5, 10.3], unadjusted
P
= 3.0 × 10
–7
; peripheral follicle location in 55% vs 18% of ovaries,
P
= 7.9 × 10
–6
; visible central ovarian stroma in 61% vs 24% of ovaries,
P
= 2.3 × 10
–5
). Follicle number and calculated ovarian volume were not concordant with clinical/biochemical assignment of PCOS/control status in 36 (23%) and 52 (34%) of ovaries, respectively.
Conclusion
Ovarian morphology overlaps in PCOS cases and controls, emphasising the importance of considering clinical/biochemical presentation together with imaging ovarian morphology in the diagnosis of PCOS.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19890641</pmid><doi>10.1007/s00330-009-1643-8</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Adolescent Adult Biomarkers - analysis Case-Control Studies Diabetes Diagnostic Radiology Endocrinology Female Follicles Humans Imaging Internal Medicine Interventional Radiology Magnetic Resonance Magnetic resonance imaging Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Menstruation Metabolism Middle Aged Morphology Neuroradiology Ovarian Follicle - pathology Ovaries Polycystic ovary syndrome Polycystic Ovary Syndrome - pathology Premenopause Radiology Ultrasonic imaging Ultrasound |
title | Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging |
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