Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. I...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-02, Vol.70 (4), p.1668-1678
Hauptverfasser:	NAZARENKO, Irina, RANA, Sanyukta, BAUMANN, Alexandra, MCALEAR, Jessica, HELLWIG, Andrea, TRENDELENBURG, Michael, LOCHNIT, Günter, PREISSNER, Klaus T, ZÖLLER, Margot
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Antigens, Neoplasm - physiology Antigens, Surface - genetics Antigens, Surface - metabolism Antigens, Surface - physiology Antineoplastic agents Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - genetics Cell Membrane - metabolism Cell Proliferation - drug effects Cells, Cultured Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Cells - physiology Exosomes - metabolism Exosomes - pathology Exosomes - physiology Gene Expression Regulation, Neoplastic - drug effects Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Proteins - physiology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pharmacology. Drug treatments Rats RNA, Small Interfering - pharmacology Signal Transduction - drug effects Signal Transduction - genetics Tetraspanins Tumors
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