SiRNA-mediated IGF-1R inhibition sensitizes human colon cancer SW480 cells to radiation

Abstract Purpose. Insulin like growth factor receptor 1 (IGF-1R) is well-documented to play a key role in radiation response and tumor radiosensitivity, thus offering an attractive clinic drug target to enhance tumor sensitivity to anti-cancer radiotherapy. Material and methods. Human colon carcinom...

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Veröffentlicht in:	Acta oncologica 2010, Vol.49 (1), p.70-75
Hauptverfasser:	Yavari, Kamal, Taghikhani, Mohammad, Maragheh, Mohammad Ghannadi, Mesbah-Namin, Seyed A., Babaei, Mohammad Hosein, Arfaee, Ali Jabbary, Madani, Hossein, Mirzaei, Hamid Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Colonic Neoplasms - genetics Enzyme-Linked Immunosorbent Assay Humans Radiation Tolerance - genetics Radiation-Sensitizing Agents - pharmacology Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - biosynthesis Receptor, IGF Type 1 - genetics Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Messenger - genetics RNA, Small Interfering - pharmacology Transfection
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