Matrix metalloproteinase (MMP)-7 in salivary gland cancer
Introduction. High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-ye...
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| Veröffentlicht in: | Acta oncologica 2010, Vol.49 (1), p.85-90 |
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| creator | Luukkaa, Heikki Klemi, Pekka Hirsimäki, Pirkko Vahlberg, Tero Kivisaari, Atte Kähäri, Veli-Matti Grénman, Reidar |
| description | Introduction. High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients. Material and methods. Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC. The samples represent the entire SGC population in Finland from 1991-1996. Mortality follow-up ended December 31, 2006. Results. The study population of 107 patients consisted of 47 male and 60 female subjects, ranging in age at the time of diagnosis between 23 and 90 years. The minimum follow-up time was 10.6 years and the maximum 15.9 years. By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0). Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0). VCI Ki-67 was an important prognostic factor for survival of the entire data set (p < 0.0001, HR 4.7, 95% Cl 2.3-9.8). Conclusions. MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma. |
| doi_str_mv | 10.3109/02841860903287197 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733857458</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733857458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-bcc39cda8c30a2d51bfb6ccf4721d07d42fba50b249478fdccbd2d014def66e43</originalsourceid><addsrcrecordid>eNp9kEtLw0AUhQdRbK3-ADeSnbqIznsyuJLiC1p0odBdmMzDpkySOpOI_nuntOBCcHUW9zuHcw8ApwheEQTlNcQFRQWHEhJcCCTFHhgjzlCOMV_sg_HmnidgMQJHMa4ghJgIdghGSEosGadjIOeqD_VX1theed-tQ9fbulXRZhfz-ctlLrK6zaLy9acK39m7V63JtGq1DcfgwCkf7clOJ-Dt_u51-pjPnh-eprezXBPJ-rzSSbVRhSZQYcNQ5SqutaMCIwOFodhVisEKU0lF4YzWlcEGImqs49xSMgHn29zU7WOwsS-bOmrrUxXbDbEUhBRMUFYkEm1JHboYg3XlOtRN6l0iWG4GK_8Mljxnu_Shaqz5dewWSsDNFqhb14VGLa3y_VKrYMtVN4Q2vf5P_A_kBnhM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733857458</pqid></control><display><type>article</type><title>Matrix metalloproteinase (MMP)-7 in salivary gland cancer</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Taylor & Francis Journals Complete</source><source>Alma/SFX Local Collection</source><creator>Luukkaa, Heikki ; Klemi, Pekka ; Hirsimäki, Pirkko ; Vahlberg, Tero ; Kivisaari, Atte ; Kähäri, Veli-Matti ; Grénman, Reidar</creator><creatorcontrib>Luukkaa, Heikki ; Klemi, Pekka ; Hirsimäki, Pirkko ; Vahlberg, Tero ; Kivisaari, Atte ; Kähäri, Veli-Matti ; Grénman, Reidar</creatorcontrib><description>Introduction. High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients. Material and methods. Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC. The samples represent the entire SGC population in Finland from 1991-1996. Mortality follow-up ended December 31, 2006. Results. The study population of 107 patients consisted of 47 male and 60 female subjects, ranging in age at the time of diagnosis between 23 and 90 years. The minimum follow-up time was 10.6 years and the maximum 15.9 years. By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0). Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0). VCI Ki-67 was an important prognostic factor for survival of the entire data set (p < 0.0001, HR 4.7, 95% Cl 2.3-9.8). Conclusions. MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/02841860903287197</identifier><identifier>PMID: 19929564</identifier><language>eng</language><publisher>England: Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Carcinoma, Acinar Cell - metabolism ; Carcinoma, Acinar Cell - mortality ; Carcinoma, Acinar Cell - pathology ; Carcinoma, Ductal - metabolism ; Carcinoma, Ductal - mortality ; Carcinoma, Ductal - pathology ; Carcinoma, Mucoepidermoid - metabolism ; Carcinoma, Mucoepidermoid - mortality ; Carcinoma, Mucoepidermoid - pathology ; Female ; Humans ; Immunohistochemistry ; Male ; Matrix Metalloproteinase 7 - biosynthesis ; Middle Aged ; Neoplasm Staging ; Prognosis ; Salivary Gland Neoplasms - metabolism ; Salivary Gland Neoplasms - mortality</subject><ispartof>Acta oncologica, 2010, Vol.49 (1), p.85-90</ispartof><rights>Informa UK Ltd 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-bcc39cda8c30a2d51bfb6ccf4721d07d42fba50b249478fdccbd2d014def66e43</citedby><cites>FETCH-LOGICAL-c395t-bcc39cda8c30a2d51bfb6ccf4721d07d42fba50b249478fdccbd2d014def66e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02841860903287197$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02841860903287197$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4021,27921,27922,27923,61219,61400</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19929564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luukkaa, Heikki</creatorcontrib><creatorcontrib>Klemi, Pekka</creatorcontrib><creatorcontrib>Hirsimäki, Pirkko</creatorcontrib><creatorcontrib>Vahlberg, Tero</creatorcontrib><creatorcontrib>Kivisaari, Atte</creatorcontrib><creatorcontrib>Kähäri, Veli-Matti</creatorcontrib><creatorcontrib>Grénman, Reidar</creatorcontrib><title>Matrix metalloproteinase (MMP)-7 in salivary gland cancer</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Introduction. High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients. Material and methods. Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC. The samples represent the entire SGC population in Finland from 1991-1996. Mortality follow-up ended December 31, 2006. Results. The study population of 107 patients consisted of 47 male and 60 female subjects, ranging in age at the time of diagnosis between 23 and 90 years. The minimum follow-up time was 10.6 years and the maximum 15.9 years. By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0). Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0). VCI Ki-67 was an important prognostic factor for survival of the entire data set (p < 0.0001, HR 4.7, 95% Cl 2.3-9.8). Conclusions. MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Acinar Cell - metabolism</subject><subject>Carcinoma, Acinar Cell - mortality</subject><subject>Carcinoma, Acinar Cell - pathology</subject><subject>Carcinoma, Ductal - metabolism</subject><subject>Carcinoma, Ductal - mortality</subject><subject>Carcinoma, Ductal - pathology</subject><subject>Carcinoma, Mucoepidermoid - metabolism</subject><subject>Carcinoma, Mucoepidermoid - mortality</subject><subject>Carcinoma, Mucoepidermoid - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Matrix Metalloproteinase 7 - biosynthesis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Salivary Gland Neoplasms - metabolism</subject><subject>Salivary Gland Neoplasms - mortality</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK3-ADeSnbqIznsyuJLiC1p0odBdmMzDpkySOpOI_nuntOBCcHUW9zuHcw8ApwheEQTlNcQFRQWHEhJcCCTFHhgjzlCOMV_sg_HmnidgMQJHMa4ghJgIdghGSEosGadjIOeqD_VX1theed-tQ9fbulXRZhfz-ctlLrK6zaLy9acK39m7V63JtGq1DcfgwCkf7clOJ-Dt_u51-pjPnh-eprezXBPJ-rzSSbVRhSZQYcNQ5SqutaMCIwOFodhVisEKU0lF4YzWlcEGImqs49xSMgHn29zU7WOwsS-bOmrrUxXbDbEUhBRMUFYkEm1JHboYg3XlOtRN6l0iWG4GK_8Mljxnu_Shaqz5dewWSsDNFqhb14VGLa3y_VKrYMtVN4Q2vf5P_A_kBnhM</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Luukkaa, Heikki</creator><creator>Klemi, Pekka</creator><creator>Hirsimäki, Pirkko</creator><creator>Vahlberg, Tero</creator><creator>Kivisaari, Atte</creator><creator>Kähäri, Veli-Matti</creator><creator>Grénman, Reidar</creator><general>Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Matrix metalloproteinase (MMP)-7 in salivary gland cancer</title><author>Luukkaa, Heikki ; Klemi, Pekka ; Hirsimäki, Pirkko ; Vahlberg, Tero ; Kivisaari, Atte ; Kähäri, Veli-Matti ; Grénman, Reidar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-bcc39cda8c30a2d51bfb6ccf4721d07d42fba50b249478fdccbd2d014def66e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Acinar Cell - metabolism</topic><topic>Carcinoma, Acinar Cell - mortality</topic><topic>Carcinoma, Acinar Cell - pathology</topic><topic>Carcinoma, Ductal - metabolism</topic><topic>Carcinoma, Ductal - mortality</topic><topic>Carcinoma, Ductal - pathology</topic><topic>Carcinoma, Mucoepidermoid - metabolism</topic><topic>Carcinoma, Mucoepidermoid - mortality</topic><topic>Carcinoma, Mucoepidermoid - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Matrix Metalloproteinase 7 - biosynthesis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Salivary Gland Neoplasms - metabolism</topic><topic>Salivary Gland Neoplasms - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luukkaa, Heikki</creatorcontrib><creatorcontrib>Klemi, Pekka</creatorcontrib><creatorcontrib>Hirsimäki, Pirkko</creatorcontrib><creatorcontrib>Vahlberg, Tero</creatorcontrib><creatorcontrib>Kivisaari, Atte</creatorcontrib><creatorcontrib>Kähäri, Veli-Matti</creatorcontrib><creatorcontrib>Grénman, Reidar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luukkaa, Heikki</au><au>Klemi, Pekka</au><au>Hirsimäki, Pirkko</au><au>Vahlberg, Tero</au><au>Kivisaari, Atte</au><au>Kähäri, Veli-Matti</au><au>Grénman, Reidar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matrix metalloproteinase (MMP)-7 in salivary gland cancer</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2010</date><risdate>2010</risdate><volume>49</volume><issue>1</issue><spage>85</spage><epage>90</epage><pages>85-90</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><abstract>Introduction. High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients. Material and methods. Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC. The samples represent the entire SGC population in Finland from 1991-1996. Mortality follow-up ended December 31, 2006. Results. The study population of 107 patients consisted of 47 male and 60 female subjects, ranging in age at the time of diagnosis between 23 and 90 years. The minimum follow-up time was 10.6 years and the maximum 15.9 years. By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0). Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0). VCI Ki-67 was an important prognostic factor for survival of the entire data set (p < 0.0001, HR 4.7, 95% Cl 2.3-9.8). Conclusions. MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.</abstract><cop>England</cop><pub>Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS)</pub><pmid>19929564</pmid><doi>10.3109/02841860903287197</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma, Acinar Cell - metabolism Carcinoma, Acinar Cell - mortality Carcinoma, Acinar Cell - pathology Carcinoma, Ductal - metabolism Carcinoma, Ductal - mortality Carcinoma, Ductal - pathology Carcinoma, Mucoepidermoid - metabolism Carcinoma, Mucoepidermoid - mortality Carcinoma, Mucoepidermoid - pathology Female Humans Immunohistochemistry Male Matrix Metalloproteinase 7 - biosynthesis Middle Aged Neoplasm Staging Prognosis Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - mortality |
| title | Matrix metalloproteinase (MMP)-7 in salivary gland cancer |
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