Giant Lysosomes in the Renal Proximal Tubules - A Morphological Characteristic of DBA/2 and DBA/1 Mouse Kidneys

The DBA/2Cr mouse is characterized by the presence of giant lysosomes located in the proximal convoluted tubules of males and proximal straight tubules of females. However, it remains unclear whether these giant lysosomes in the proximal tubules are characteristic of DBA/2Cr specifically, or are com...

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Veröffentlicht in:Experimental Animals 2003, Vol.52(2), pp.159-163
Hauptverfasser: YABUKI, Akira, MATSUMOTO, Mitsuharu, NISHINAKAGAWA, Hayao, SUZUKI, Syusaku
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container_title Experimental Animals
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creator YABUKI, Akira
MATSUMOTO, Mitsuharu
NISHINAKAGAWA, Hayao
SUZUKI, Syusaku
description The DBA/2Cr mouse is characterized by the presence of giant lysosomes located in the proximal convoluted tubules of males and proximal straight tubules of females. However, it remains unclear whether these giant lysosomes in the proximal tubules are characteristic of DBA/2Cr specifically, or are common to other DBA/2 substrains and DBA/1. The present study investigated the morphology of kidneys from DBA/2CrSlc, DBA/2JJcl, DBA/2NCrj and DBA/1JNCrj mice of both sexes. Giant lysosomes in the renal proximal tubules were found to represent common morphological characteristic of both DBA/2 and DBA/1JN.
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source J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Animals
DBA/1
DBA/2
Female
giant lysosomes
kidney
Kidney Tubules, Proximal - anatomy & histology
Kidney Tubules, Proximal - ultrastructure
Lysosomes - ultrastructure
Male
Mice
Mice, Inbred DBA
title Giant Lysosomes in the Renal Proximal Tubules - A Morphological Characteristic of DBA/2 and DBA/1 Mouse Kidneys
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