Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease

There is substantial evidence that excitotoxicity and oxidative damage may contribute to Huntington's disease (HD) pathogenesis. We examined whether the novel anti‐oxidant compound BN82451 exerts neuroprotective effects in the R6/2 transgenic mouse model of HD. Oral administration of BN82451 si...

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Veröffentlicht in:	Journal of neurochemistry 2003-07, Vol.86 (1), p.267-272
Hauptverfasser:	Klivenyi, Peter, Ferrante, Robert J., Gardian, Gabrielle, Browne, Susan, Chabrier, Pierre‐Etienne, Beal, M. Flint
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antioxidants - therapeutic use Behavior, Animal - drug effects Biological and medical sciences Brain - drug effects Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal experimental therapeutics huntington Huntington Disease - drug therapy Huntington Disease - genetics Huntington Disease - pathology Inclusion Bodies - drug effects Inclusion Bodies - metabolism Inclusion Bodies - pathology inflammation Medical sciences Mice Mice, Transgenic Motor Activity - drug effects neurodegeneration Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - therapeutic use oxidative damage Survival Rate transgenic mice Treatment Outcome Ubiquitin - biosynthesis
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