Experimental xenoimplantation of antlerogenic cells into mandibular bone lesions in rabbits: two-year follow-up
Different types of cells require activation, and take part in annual, dynamic growth of deer antlers. Stem cells play the most important role in this process. This report shows the results of a two-year long observation of xenogenic implant of antlerogenic stem cells (cell line MIC-1). The cells wer...
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| Veröffentlicht in: | In vivo (Athens) 2010-03, Vol.24 (2), p.165-172 |
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| creator | Cegielski, Marek Dziewiszek, Wojciech Zabel, Maciej Dziegiel, Piotr Kuryszko, Jan Izykowska, Ilona Zatoński, Maciej Bochnia, Marek |
| description | Different types of cells require activation, and take part in annual, dynamic growth of deer antlers. Stem cells play the most important role in this process. This report shows the results of a two-year long observation of xenogenic implant of antlerogenic stem cells (cell line MIC-1). The cells were derived from growing antler of a deer (Cervus elaphus), seeded onto Spongostan and placed in postoperative lesions of mandibular bones of 15 experimental rabbits. The healing process observed in the implantation sites in all rabbits was normal, and no local inflammatory response was ever observed. Histological and immunohistochemical evaluations were performed after 1, 2, 6, 12 and 24 months, and confirmed the participation of xenogenic cells in the regeneration processes, as well as a lack of rejection of the implants. The deficiencies in the bones were replaced by newly formed, thick fibrous bone tissue that underwent mineralization and was later remodelled into lamellar bone. The results of the experiment with rabbits allow us to believe that antlerogenic cells could be used in reconstruction of bone tissues in other species as well. |
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The results of the experiment with rabbits allow us to believe that antlerogenic cells could be used in reconstruction of bone tissues in other species as well.</description><identifier>ISSN: 0258-851X</identifier><identifier>PMID: 20363989</identifier><language>eng</language><publisher>Greece</publisher><subject>Animals ; Antlers - cytology ; Bone Remodeling - physiology ; Deer ; Female ; Fibrin Foam - pharmacology ; Follow-Up Studies ; Fracture Healing ; Graft Rejection - pathology ; Graft Survival ; Immunohistochemistry ; Mandible - diagnostic imaging ; Mandible - pathology ; Mandibular Diseases - diagnostic imaging ; Mandibular Diseases - pathology ; Mandibular Diseases - therapy ; Microscopy, Electron ; Rabbits ; Radiography ; Regeneration - physiology ; Stem Cell Transplantation - methods ; Transplantation, Heterologous - methods ; Ultrasonography</subject><ispartof>In vivo (Athens), 2010-03, Vol.24 (2), p.165-172</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20363989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cegielski, Marek</creatorcontrib><creatorcontrib>Dziewiszek, Wojciech</creatorcontrib><creatorcontrib>Zabel, Maciej</creatorcontrib><creatorcontrib>Dziegiel, Piotr</creatorcontrib><creatorcontrib>Kuryszko, Jan</creatorcontrib><creatorcontrib>Izykowska, Ilona</creatorcontrib><creatorcontrib>Zatoński, Maciej</creatorcontrib><creatorcontrib>Bochnia, Marek</creatorcontrib><title>Experimental xenoimplantation of antlerogenic cells into mandibular bone lesions in rabbits: two-year follow-up</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Different types of cells require activation, and take part in annual, dynamic growth of deer antlers. Stem cells play the most important role in this process. This report shows the results of a two-year long observation of xenogenic implant of antlerogenic stem cells (cell line MIC-1). The cells were derived from growing antler of a deer (Cervus elaphus), seeded onto Spongostan and placed in postoperative lesions of mandibular bones of 15 experimental rabbits. The healing process observed in the implantation sites in all rabbits was normal, and no local inflammatory response was ever observed. Histological and immunohistochemical evaluations were performed after 1, 2, 6, 12 and 24 months, and confirmed the participation of xenogenic cells in the regeneration processes, as well as a lack of rejection of the implants. The deficiencies in the bones were replaced by newly formed, thick fibrous bone tissue that underwent mineralization and was later remodelled into lamellar bone. The results of the experiment with rabbits allow us to believe that antlerogenic cells could be used in reconstruction of bone tissues in other species as well.</description><subject>Animals</subject><subject>Antlers - cytology</subject><subject>Bone Remodeling - physiology</subject><subject>Deer</subject><subject>Female</subject><subject>Fibrin Foam - pharmacology</subject><subject>Follow-Up Studies</subject><subject>Fracture Healing</subject><subject>Graft Rejection - pathology</subject><subject>Graft Survival</subject><subject>Immunohistochemistry</subject><subject>Mandible - diagnostic imaging</subject><subject>Mandible - pathology</subject><subject>Mandibular Diseases - diagnostic imaging</subject><subject>Mandibular Diseases - pathology</subject><subject>Mandibular Diseases - therapy</subject><subject>Microscopy, Electron</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Regeneration - physiology</subject><subject>Stem Cell Transplantation - methods</subject><subject>Transplantation, Heterologous - methods</subject><subject>Ultrasonography</subject><issn>0258-851X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtPwzAMgHMAsTH4Cyg3TpWypnmUG5rGQ5rEZQduVZI6KChNSpNq278nE-NkW_5s2d8VWpKayUqy9ecC3ab0TQgXhNQ3aFETymkr2yWK2-MIkxsgZOXxEUJ0w-hVqbKLAUeLS-5hil8QnMEGvE_YhRzxoELv9OzVhHUMgD2kMnFu4klp7XJ6wvkQqxMUwkbv46Gaxzt0bZVPcH-JK7R_2e43b9Xu4_V987yrxnpNcmUM79cCrGZtbywRSrTKNhYa25YfNFWSQm-4qQXXDZfESkMEY5Jp4I1hdIUe_9aOU_yZIeVucOl8vAoQ59QJSosX2daFfLiQsx6g78YiQ02n7l8R_QW3AWTw</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Cegielski, Marek</creator><creator>Dziewiszek, Wojciech</creator><creator>Zabel, Maciej</creator><creator>Dziegiel, Piotr</creator><creator>Kuryszko, Jan</creator><creator>Izykowska, Ilona</creator><creator>Zatoński, Maciej</creator><creator>Bochnia, Marek</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Experimental xenoimplantation of antlerogenic cells into mandibular bone lesions in rabbits: two-year follow-up</title><author>Cegielski, Marek ; Dziewiszek, Wojciech ; Zabel, Maciej ; Dziegiel, Piotr ; Kuryszko, Jan ; Izykowska, Ilona ; Zatoński, Maciej ; Bochnia, Marek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-cc6d17efb59dcf07a79af4fe4f9670b3a83edc6c276b4680f8c075585be64c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antlers - cytology</topic><topic>Bone Remodeling - physiology</topic><topic>Deer</topic><topic>Female</topic><topic>Fibrin Foam - pharmacology</topic><topic>Follow-Up Studies</topic><topic>Fracture Healing</topic><topic>Graft Rejection - pathology</topic><topic>Graft Survival</topic><topic>Immunohistochemistry</topic><topic>Mandible - diagnostic imaging</topic><topic>Mandible - pathology</topic><topic>Mandibular Diseases - diagnostic imaging</topic><topic>Mandibular Diseases - pathology</topic><topic>Mandibular Diseases - therapy</topic><topic>Microscopy, Electron</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Regeneration - physiology</topic><topic>Stem Cell Transplantation - methods</topic><topic>Transplantation, Heterologous - methods</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cegielski, Marek</creatorcontrib><creatorcontrib>Dziewiszek, Wojciech</creatorcontrib><creatorcontrib>Zabel, Maciej</creatorcontrib><creatorcontrib>Dziegiel, Piotr</creatorcontrib><creatorcontrib>Kuryszko, Jan</creatorcontrib><creatorcontrib>Izykowska, Ilona</creatorcontrib><creatorcontrib>Zatoński, Maciej</creatorcontrib><creatorcontrib>Bochnia, Marek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cegielski, Marek</au><au>Dziewiszek, Wojciech</au><au>Zabel, Maciej</au><au>Dziegiel, Piotr</au><au>Kuryszko, Jan</au><au>Izykowska, Ilona</au><au>Zatoński, Maciej</au><au>Bochnia, Marek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental xenoimplantation of antlerogenic cells into mandibular bone lesions in rabbits: two-year follow-up</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>24</volume><issue>2</issue><spage>165</spage><epage>172</epage><pages>165-172</pages><issn>0258-851X</issn><abstract>Different types of cells require activation, and take part in annual, dynamic growth of deer antlers. Stem cells play the most important role in this process. This report shows the results of a two-year long observation of xenogenic implant of antlerogenic stem cells (cell line MIC-1). The cells were derived from growing antler of a deer (Cervus elaphus), seeded onto Spongostan and placed in postoperative lesions of mandibular bones of 15 experimental rabbits. The healing process observed in the implantation sites in all rabbits was normal, and no local inflammatory response was ever observed. Histological and immunohistochemical evaluations were performed after 1, 2, 6, 12 and 24 months, and confirmed the participation of xenogenic cells in the regeneration processes, as well as a lack of rejection of the implants. The deficiencies in the bones were replaced by newly formed, thick fibrous bone tissue that underwent mineralization and was later remodelled into lamellar bone. The results of the experiment with rabbits allow us to believe that antlerogenic cells could be used in reconstruction of bone tissues in other species as well.</abstract><cop>Greece</cop><pmid>20363989</pmid><tpages>8</tpages></addata></record> |
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| subjects | Animals Antlers - cytology Bone Remodeling - physiology Deer Female Fibrin Foam - pharmacology Follow-Up Studies Fracture Healing Graft Rejection - pathology Graft Survival Immunohistochemistry Mandible - diagnostic imaging Mandible - pathology Mandibular Diseases - diagnostic imaging Mandibular Diseases - pathology Mandibular Diseases - therapy Microscopy, Electron Rabbits Radiography Regeneration - physiology Stem Cell Transplantation - methods Transplantation, Heterologous - methods Ultrasonography |
| title | Experimental xenoimplantation of antlerogenic cells into mandibular bone lesions in rabbits: two-year follow-up |
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