Systemic sarcoidosis after treatment with pegylated interferon-alpha

A few cases of sarcoidosis have been reported in the course of chronic hepatitis C, with or without alpha-interferon treatment. We report a 54-year-old woman who presented a typical sarcoidosis in this context. The sarcoidosis involved skin, lungs and eyes. There are data in the literature supportin...

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Veröffentlicht in:La revue de medecine interne 2010-04, Vol.31 (4), p.e11-e13
Hauptverfasser: Le Bras, M, Hervier, B, Wastiaux, H, Masseau, A, Durant, C, Jossic, F, Hamidou, M
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container_title La revue de medecine interne
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creator Le Bras, M
Hervier, B
Wastiaux, H
Masseau, A
Durant, C
Jossic, F
Hamidou, M
description A few cases of sarcoidosis have been reported in the course of chronic hepatitis C, with or without alpha-interferon treatment. We report a 54-year-old woman who presented a typical sarcoidosis in this context. The sarcoidosis involved skin, lungs and eyes. There are data in the literature supporting a pathogenic link between alpha-interferon and sarcoidosis: alpha-interferon possessing a non-specific immunologic inductor. The treatment of the sarcoidosis in this context is difficult and has to be adjusted to both the severity of the sarcoidosis and the viral hepatitis. Although sarcoidosis induced by alpha-interferon is rare, clinicians must be aware of this association.
doi_str_mv 10.1016/j.revmed.2009.03.366
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subjects Female
Humans
Interferon-alpha - adverse effects
Middle Aged
Sarcoidosis - chemically induced
title Systemic sarcoidosis after treatment with pegylated interferon-alpha
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