Lynch Syndrome―Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry

The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families. This observational study involved 107 cases of breast cancer identified from the Colorectal Cancer Family...

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Veröffentlicht in:	Clinical cancer research 2010-04, Vol.16 (7), p.2214-2224
Hauptverfasser:	WASH, Michael D, BUCHANAN, Daniel D, JENKINS, Mark A, PHILLIPS, Kerry D, SUTHERS, Graeme K, GEORGE, Jill, GOLDBLATT, Jack, MUIR, Amanda, TUCKER, Kathy, PELZER, Elise, GATTAS, Michael R, WOODALL, Sonja, CUMMINGS, Margaret C, PARRY, Susan, MACRAE, Finlay A, HAILE, Robert W, BARON, John A, POTTER, John D, LE MARCHAND, Loic, BAPAT, Bharati, THIBODEAU, Stephen N, LINDOR, Noralane M, MCGUCKIN, Michael A, PEARSON, Sally-Ann, YOUNG, Joanne P, ARNOLD, Sven T, CLENDENNING, Mark, WALTERS, Rhiannon, MCKEONE, Diane M, SPURDLE, Amanda B, HOPPER, John L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Breast Neoplasms - complications Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms, Male - genetics Breast Neoplasms, Male - metabolism Carcinoma - complications Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Case-Control Studies Colonic Neoplasms - complications Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - complications Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism Colorectal Neoplasms, Hereditary Nonpolyposis - pathology DNA Mismatch Repair - genetics Family Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Carrier Screening Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics Humans Male Mammary gland diseases Medical sciences Middle Aged Mutation Pharmacology. Drug treatments Registries Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Beschreibung
Zusammenfassung:	The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families. This observational study involved 107 cases of breast cancer identified from the Colorectal Cancer Family Registry (Colon CFR) from 90 families in which (a) both breast and colon cancer co-occurred, (b) families met either modified Amsterdam criteria, or had at least one early-onset (
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-09-3058