A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis

Curcumin is a highly pleiotropic molecule with significant regulatory effects upon inflammation and inflammatory related diseases. However curcumin has one major important limitation in which it has poor bioavailability. Design of synthetic structural derivatives of curcumin is but one approach that...

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Veröffentlicht in:	European journal of pharmacology 2010-02, Vol.628 (1), p.247-254
Hauptverfasser:	Tham, Chau Ling, Liew, Choi Yi, Lam, Kok Wai, Mohamad, Azam-Shah, Kim, Min Kyu, Cheah, Yoke Kqueen, Zakaria, Zainul-Amirudin, Sulaiman, Mohd-Roslan, Lajis, Nordin H., Israf, Daud A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell Survival - drug effects Chemokine Chemokines - biosynthesis Chemokines - metabolism Chemokines - secretion Curcumin Curcumin - analogs & derivatives Curcumin - chemical synthesis Curcumin - pharmacology Curcuminoid Cyclohexanones - chemical synthesis Cyclohexanones - pharmacology Cytokine Cytokines - biosynthesis Cytokines - secretion Dose-Response Relationship, Drug Gene Expression Regulation, Enzymologic - drug effects Humans Inflammation - metabolism Inflammation - pathology iNOS Macrophage Medical sciences Mice Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Pharmacology. Drug treatments
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