Locomotor activity induced by MK-801 is enhanced in dopamine D3 receptor knockout mice but suppression by dopamine D3/D2 antagonists does not occur through the dopamine D3 receptor

There are contradictory data regarding the role of the dopamine D(3) receptor in regulating N-methyl-d-aspartate (NMDA) receptor antagonist (e.g., dizocilpine) induced hyperactivity. The purpose of the present study was to examine the interaction of dopamine D(3) receptor preferring antagonists U991...

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Veröffentlicht in:	European journal of pharmacology 2010-02, Vol.627 (1-3), p.167-172
Hauptverfasser:	YARKOV, Alex V, DER, Terry C, JOYCE, Jeffrey N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Behavior, Animal - drug effects Biological and medical sciences Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Dopamine D2 Receptor Antagonists Female Gene Knockout Techniques Genotype Locomotion - drug effects Male Medical sciences Mice Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, Dopamine D3 - antagonists & inhibitors Receptors, Dopamine D3 - deficiency Receptors, Dopamine D3 - genetics Receptors, Dopamine D3 - metabolism Schizophrenia
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