Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation

Histone modification through acetylation and deacetylation is a key process in transcription, DNA replication, and chromosome segregation. During mitosis, histones are highly acetylated and chromatin is condensed. Here, we investigate the mechanistic involvement of histone deacetylase (HDAC) activit...

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Veröffentlicht in:	Oncogene 2003-06, Vol.22 (25), p.3853-3858
Hauptverfasser:	Shin, Hyun-Jin, Baek, Kwan-Hyuck, Jeon, Ae-Hwa, Kim, So-Jung, Jang, Kyung-Lib, Sung, Young-Chul, Kim, Chang-Min, Lee, Chang-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation - drug effects Acetyltransferases - antagonists & inhibitors Acetyltransferases - physiology Apoptosis Apoptosis - drug effects Biological and medical sciences Biomarkers Cancer Cell Biology Cell cycle Cell Cycle Proteins Cell survival Chromatin Chromosome Aberrations Chromosomes Chromosomes, Human - ultrastructure Cyclin A - metabolism Cyclin B - metabolism Deacetylation DNA biosynthesis Enzyme Inhibitors - pharmacology Extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Genes. Genome Genomic instability HeLa Cells - cytology HeLa Cells - enzymology Histone Acetyltransferases Histone deacetylase Histones - metabolism Human Genetics Humans Hydroxamic Acids - pharmacology Inhibitor of Apoptosis Proteins Internal Medicine Interphase - drug effects Kinases Localization MAP Kinase Signaling System - drug effects Medicine Medicine & Public Health Metaphase - drug effects Microtubules - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - physiology Mitosis Mitosis - drug effects Mitosis - physiology Molecular and cellular biology Molecular genetics Nocodazole - pharmacology Oncology original-paper p38 Mitogen-Activated Protein Kinases Phosphorylation Polyploidy Protein Kinases - genetics Protein Kinases - metabolism Protein Processing, Post-Translational - drug effects Protein-Serine-Threonine Kinases Proteins - metabolism Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - physiology Transcription Yeast
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