Immunization with myelin or recombinant Nogo-66/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cord

We have shown previously that immunization with myelin in incomplete Freund’s adjuvant (IFA) is able to promote robust regeneration of corticospinal tract fibers in adult mice. In the present study the effectiveness of such immunization with myelin was compared to that of a combination of two axon g...

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Veröffentlicht in:	Molecular and cellular neuroscience 2003-06, Vol.23 (2), p.251-263
Hauptverfasser:	Sicotte, Maryline, Tsatas, Ourania, Jeong, Suh Young, Cai, Chuan-Qi, He, Zhigang, David, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Hydroxide - pharmacology Animals Female Freund's Adjuvant - pharmacology Growth Cones - drug effects Growth Cones - metabolism Growth Cones - ultrastructure Immunotherapy - methods Immunotherapy - trends Lipids Mice Mice, Inbred Strains Myelin Proteins - immunology Myelin Proteins - pharmacology Myelin Proteins - therapeutic use Myelin Sheath - immunology Myelin Sheath - metabolism Myelin-Associated Glycoprotein - immunology Myelin-Associated Glycoprotein - pharmacology Myelin-Associated Glycoprotein - therapeutic use Nerve Fibers, Myelinated - immunology Nerve Fibers, Myelinated - metabolism Nerve Fibers, Myelinated - ultrastructure Nerve Regeneration - genetics Nerve Regeneration - immunology Nogo protein Nogo Proteins Pyramidal Tracts - drug effects Pyramidal Tracts - growth & development Pyramidal Tracts - injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - genetics Spinal Cord Injuries - immunology Treatment Outcome
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