Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events
OBJECTIVE—Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territor...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2010-03, Vol.30 (3), p.612-619 |
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| creator | de Kleijn, Dominique P.V Moll, Frans L Hellings, Willem E Ozsarlak-Sozer, Gonen de Bruin, Peter Doevendans, Pieter A Vink, Aryan Catanzariti, Louise M Schoneveld, Arjan H Algra, Ale Daemen, Mat J Biessen, E A de Jager, W Zhang, Huoming de Vries, Jean-Paul Falk, Erling Lim, Sai K van der Spek, Peter J Sze, Siu Kwan Pasterkamp, Gerard |
| description | OBJECTIVE—Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories.
METHODS AND RESULTS—AtheroExpress is a biobank collecting atherosclerotic lesions during surgery, with a 3-year follow-up. The composite primary outcome encompasses all cardiovascular events and interventions, eg, cardiovascular death, myocardial infarction, stroke, and endovascular interventions. A proteomics search identified osteopontin as a potential plaque biomarker. Patients undergoing carotid surgery (n=574) served as the cohort in which plaque osteopontin levels were examined in relation to their outcome during follow-up and was validated in a cohort of patients undergoing femoral endarterectomy (n=151). Comparing the highest quartile of carotid plaque osteopontin levels with quartile 1 showed a hazard ratio for the primary outcome of 3.8 (95% confidence interval, 2.6–5.9). The outcome did not change after adjustment for plaque characteristics and traditional risk factors (hazard ratio, 3.5; 95% confidence interval, 2.0–5.9). The femoral validation cohort showed a hazard ratio of 3.8 (95% confidence interval 2.0 to 7.4) comparing osteopontin levels in quartile 4 with quartile 1.
CONCLUSION—Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories. Local atherosclerotic plaques are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease. |
| doi_str_mv | 10.1161/ATVBAHA.109.194944 |
| format | Article |
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METHODS AND RESULTS—AtheroExpress is a biobank collecting atherosclerotic lesions during surgery, with a 3-year follow-up. The composite primary outcome encompasses all cardiovascular events and interventions, eg, cardiovascular death, myocardial infarction, stroke, and endovascular interventions. A proteomics search identified osteopontin as a potential plaque biomarker. Patients undergoing carotid surgery (n=574) served as the cohort in which plaque osteopontin levels were examined in relation to their outcome during follow-up and was validated in a cohort of patients undergoing femoral endarterectomy (n=151). Comparing the highest quartile of carotid plaque osteopontin levels with quartile 1 showed a hazard ratio for the primary outcome of 3.8 (95% confidence interval, 2.6–5.9). The outcome did not change after adjustment for plaque characteristics and traditional risk factors (hazard ratio, 3.5; 95% confidence interval, 2.0–5.9). The femoral validation cohort showed a hazard ratio of 3.8 (95% confidence interval 2.0 to 7.4) comparing osteopontin levels in quartile 4 with quartile 1.
CONCLUSION—Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories. Local atherosclerotic plaques are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.109.194944</identifier><identifier>PMID: 20018935</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Aged ; Arterial Occlusive Diseases - blood ; Arterial Occlusive Diseases - diagnosis ; Arterial Occlusive Diseases - pathology ; Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Carotid Arteries - pathology ; Carotid Stenosis - blood ; Carotid Stenosis - diagnosis ; Carotid Stenosis - pathology ; Cohort Studies ; Diabetes. Impaired glucose tolerance ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Femoral Artery - pathology ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - epidemiology ; Osteopontin - blood ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Stroke - epidemiology</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2010-03, Vol.30 (3), p.612-619</ispartof><rights>2010 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4878-3e66a58da308bed1180c7ad79ad72e68016836654ce3c6c74da9ba2e44b37d843</citedby><cites>FETCH-LOGICAL-c4878-3e66a58da308bed1180c7ad79ad72e68016836654ce3c6c74da9ba2e44b37d843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22446106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20018935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Kleijn, Dominique P.V</creatorcontrib><creatorcontrib>Moll, Frans L</creatorcontrib><creatorcontrib>Hellings, Willem E</creatorcontrib><creatorcontrib>Ozsarlak-Sozer, Gonen</creatorcontrib><creatorcontrib>de Bruin, Peter</creatorcontrib><creatorcontrib>Doevendans, Pieter A</creatorcontrib><creatorcontrib>Vink, Aryan</creatorcontrib><creatorcontrib>Catanzariti, Louise M</creatorcontrib><creatorcontrib>Schoneveld, Arjan H</creatorcontrib><creatorcontrib>Algra, Ale</creatorcontrib><creatorcontrib>Daemen, Mat J</creatorcontrib><creatorcontrib>Biessen, E A</creatorcontrib><creatorcontrib>de Jager, W</creatorcontrib><creatorcontrib>Zhang, Huoming</creatorcontrib><creatorcontrib>de Vries, Jean-Paul</creatorcontrib><creatorcontrib>Falk, Erling</creatorcontrib><creatorcontrib>Lim, Sai K</creatorcontrib><creatorcontrib>van der Spek, Peter J</creatorcontrib><creatorcontrib>Sze, Siu Kwan</creatorcontrib><creatorcontrib>Pasterkamp, Gerard</creatorcontrib><title>Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories.
METHODS AND RESULTS—AtheroExpress is a biobank collecting atherosclerotic lesions during surgery, with a 3-year follow-up. The composite primary outcome encompasses all cardiovascular events and interventions, eg, cardiovascular death, myocardial infarction, stroke, and endovascular interventions. A proteomics search identified osteopontin as a potential plaque biomarker. Patients undergoing carotid surgery (n=574) served as the cohort in which plaque osteopontin levels were examined in relation to their outcome during follow-up and was validated in a cohort of patients undergoing femoral endarterectomy (n=151). Comparing the highest quartile of carotid plaque osteopontin levels with quartile 1 showed a hazard ratio for the primary outcome of 3.8 (95% confidence interval, 2.6–5.9). The outcome did not change after adjustment for plaque characteristics and traditional risk factors (hazard ratio, 3.5; 95% confidence interval, 2.0–5.9). The femoral validation cohort showed a hazard ratio of 3.8 (95% confidence interval 2.0 to 7.4) comparing osteopontin levels in quartile 4 with quartile 1.
CONCLUSION—Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories. Local atherosclerotic plaques are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease.</description><subject>Aged</subject><subject>Arterial Occlusive Diseases - blood</subject><subject>Arterial Occlusive Diseases - diagnosis</subject><subject>Arterial Occlusive Diseases - pathology</subject><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Stenosis - blood</subject><subject>Carotid Stenosis - diagnosis</subject><subject>Carotid Stenosis - pathology</subject><subject>Cohort Studies</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Femoral Artery - pathology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Osteopontin - blood</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Stroke - epidemiology</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1vEzEQhlcIRD_gD3BAvqCeNoztWa993EalRYpEJQpXy_HOkqVOXOzdVPx7HCXAYTwz0jMjv-9U1TsOC84V_9g9fL_u7roFB7PgBg3ii-qcNwJrVFK9LDW0pm4UirPqIuefAIBCwOvqTABwbWRzXtEqehdYN20oxexDeafRs_vgfs2UWZeIOfY1zskTiwO7T_HHLuYDcj3GrUuPlDIbYmJdvy8lsaVL_Rj3Lvs5uMRu9rSb8pvq1eBCprenfFl9-3TzsLyrV19uPy-7Ve1Rt7qWpJRrdO8k6DX1nGvwretbU0KQ0sCVlko16El65VvsnVk7QYhr2fYa5WV1ddz7lOLh_5PdjtlTCG5Hcc62lVKjQAOFFEfSF9k50WCf0lj0_LYc7MFde3K39MYe3S1D70_r5_WW-n8jf-0swIcTUPS7MCS382P-zwlExUEVDo_ccwxTse0xzM-U7IZcmDb2cCepoKkFcABZ2rqE1PIPYKaSpg</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>de Kleijn, Dominique P.V</creator><creator>Moll, Frans L</creator><creator>Hellings, Willem E</creator><creator>Ozsarlak-Sozer, Gonen</creator><creator>de Bruin, Peter</creator><creator>Doevendans, Pieter A</creator><creator>Vink, Aryan</creator><creator>Catanzariti, Louise M</creator><creator>Schoneveld, Arjan H</creator><creator>Algra, Ale</creator><creator>Daemen, Mat J</creator><creator>Biessen, E A</creator><creator>de Jager, W</creator><creator>Zhang, Huoming</creator><creator>de Vries, Jean-Paul</creator><creator>Falk, Erling</creator><creator>Lim, Sai K</creator><creator>van der Spek, Peter J</creator><creator>Sze, Siu Kwan</creator><creator>Pasterkamp, Gerard</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201003</creationdate><title>Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events</title><author>de Kleijn, Dominique P.V ; Moll, Frans L ; Hellings, Willem E ; Ozsarlak-Sozer, Gonen ; de Bruin, Peter ; Doevendans, Pieter A ; Vink, Aryan ; Catanzariti, Louise M ; Schoneveld, Arjan H ; Algra, Ale ; Daemen, Mat J ; Biessen, E A ; de Jager, W ; Zhang, Huoming ; de Vries, Jean-Paul ; Falk, Erling ; Lim, Sai K ; van der Spek, Peter J ; Sze, Siu Kwan ; Pasterkamp, Gerard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4878-3e66a58da308bed1180c7ad79ad72e68016836654ce3c6c74da9ba2e44b37d843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Arterial Occlusive Diseases - blood</topic><topic>Arterial Occlusive Diseases - diagnosis</topic><topic>Arterial Occlusive Diseases - pathology</topic><topic>Associated diseases and complications</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Stenosis - blood</topic><topic>Carotid Stenosis - diagnosis</topic><topic>Carotid Stenosis - pathology</topic><topic>Cohort Studies</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Femoral Artery - pathology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Osteopontin - blood</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Stroke - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Kleijn, Dominique P.V</creatorcontrib><creatorcontrib>Moll, Frans L</creatorcontrib><creatorcontrib>Hellings, Willem E</creatorcontrib><creatorcontrib>Ozsarlak-Sozer, Gonen</creatorcontrib><creatorcontrib>de Bruin, Peter</creatorcontrib><creatorcontrib>Doevendans, Pieter A</creatorcontrib><creatorcontrib>Vink, Aryan</creatorcontrib><creatorcontrib>Catanzariti, Louise M</creatorcontrib><creatorcontrib>Schoneveld, Arjan H</creatorcontrib><creatorcontrib>Algra, Ale</creatorcontrib><creatorcontrib>Daemen, Mat J</creatorcontrib><creatorcontrib>Biessen, E A</creatorcontrib><creatorcontrib>de Jager, W</creatorcontrib><creatorcontrib>Zhang, Huoming</creatorcontrib><creatorcontrib>de Vries, Jean-Paul</creatorcontrib><creatorcontrib>Falk, Erling</creatorcontrib><creatorcontrib>Lim, Sai K</creatorcontrib><creatorcontrib>van der Spek, Peter J</creatorcontrib><creatorcontrib>Sze, Siu Kwan</creatorcontrib><creatorcontrib>Pasterkamp, Gerard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Kleijn, Dominique P.V</au><au>Moll, Frans L</au><au>Hellings, Willem E</au><au>Ozsarlak-Sozer, Gonen</au><au>de Bruin, Peter</au><au>Doevendans, Pieter A</au><au>Vink, Aryan</au><au>Catanzariti, Louise M</au><au>Schoneveld, Arjan H</au><au>Algra, Ale</au><au>Daemen, Mat J</au><au>Biessen, E A</au><au>de Jager, W</au><au>Zhang, Huoming</au><au>de Vries, Jean-Paul</au><au>Falk, Erling</au><au>Lim, Sai K</au><au>van der Spek, Peter J</au><au>Sze, Siu Kwan</au><au>Pasterkamp, Gerard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2010-03</date><risdate>2010</risdate><volume>30</volume><issue>3</issue><spage>612</spage><epage>619</epage><pages>612-619</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories.
METHODS AND RESULTS—AtheroExpress is a biobank collecting atherosclerotic lesions during surgery, with a 3-year follow-up. The composite primary outcome encompasses all cardiovascular events and interventions, eg, cardiovascular death, myocardial infarction, stroke, and endovascular interventions. A proteomics search identified osteopontin as a potential plaque biomarker. Patients undergoing carotid surgery (n=574) served as the cohort in which plaque osteopontin levels were examined in relation to their outcome during follow-up and was validated in a cohort of patients undergoing femoral endarterectomy (n=151). Comparing the highest quartile of carotid plaque osteopontin levels with quartile 1 showed a hazard ratio for the primary outcome of 3.8 (95% confidence interval, 2.6–5.9). The outcome did not change after adjustment for plaque characteristics and traditional risk factors (hazard ratio, 3.5; 95% confidence interval, 2.0–5.9). The femoral validation cohort showed a hazard ratio of 3.8 (95% confidence interval 2.0 to 7.4) comparing osteopontin levels in quartile 4 with quartile 1.
CONCLUSION—Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories. Local atherosclerotic plaques are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease.</abstract><cop>Philadelphia, PA</cop><pub>American Heart Association, Inc</pub><pmid>20018935</pmid><doi>10.1161/ATVBAHA.109.194944</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2010-03, Vol.30 (3), p.612-619 |
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| subjects | Aged Arterial Occlusive Diseases - blood Arterial Occlusive Diseases - diagnosis Arterial Occlusive Diseases - pathology Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - epidemiology Carotid Arteries - pathology Carotid Stenosis - blood Carotid Stenosis - diagnosis Carotid Stenosis - pathology Cohort Studies Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Femoral Artery - pathology Follow-Up Studies Humans Longitudinal Studies Male Medical sciences Middle Aged Myocardial Infarction - epidemiology Osteopontin - blood Predictive Value of Tests Prognosis Risk Factors Stroke - epidemiology |
| title | Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events |
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