Interaction of antimicrobial dermaseptin and its fluorescently labeled analogs with phospholipid membranes

Dermaseptin, a 34 amino-acid residue antimicrobial polypeptide [Mor, A., Nguyen, V. H., Delfour, A., Migliore-Samour, D., & Nicolas, P. (1991) Biochemistry 30, 8824-8830] was synthesized and selectively labeled at its N-terminal amino acid with either 7-nitrobenz-2-oxa-1,3-diazole-4-yl (NBD), rh...

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Veröffentlicht in:	Biochemistry (Easton) 1992-12, Vol.31 (49), p.12416-12423
Hauptverfasser:	Pouny, Yehonathan, Rapaport, Doron, Mor, Amram, Nicolas, Pierre, Shai, Yechiel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amphibian Proteins Anti-Infective Agents - metabolism Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial Cationic Peptides Biological and medical sciences Diffusion Fluoresceins - metabolism Fluorescent Dyes Lipid Bilayers - metabolism Medical sciences Miscellaneous. Antibiotics with multiple activities Molecular Sequence Data Peptides - metabolism Permeability Pharmacology. Drug treatments Phospholipids - metabolism Spectrometry, Fluorescence Thermodynamics Valinomycin
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