Surrogate end points in women's health research: science, protoscience, and pseudoscience
A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption and use of surrogate end points lacking validation, especially in cardiovascular medicine, have caused thousands of patients' deaths...
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| Veröffentlicht in: | Fertility and sterility 2010-04, Vol.93 (6), p.1731-1734 |
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| container_end_page | 1734 |
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| container_issue | 6 |
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| container_title | Fertility and sterility |
| container_volume | 93 |
| creator | Grimes, David A., M.D Schulz, Kenneth F., Ph.D., M.B.A Raymond, Elizabeth G., M.D., M.P.H |
| description | A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption and use of surrogate end points lacking validation, especially in cardiovascular medicine, have caused thousands of patients' deaths, a serious violation of the ethical principle of beneficence. |
| doi_str_mv | 10.1016/j.fertnstert.2009.12.054 |
| format | Article |
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| ispartof | Fertility and sterility, 2010-04, Vol.93 (6), p.1731-1734 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biomarkers - analysis Female Health Planning Guidelines Humans Internal Medicine Obstetrics and Gynecology Research - standards Research - trends Research Design Science - methods Science - standards Science - trends Validation Studies as Topic Women's Health |
| title | Surrogate end points in women's health research: science, protoscience, and pseudoscience |
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