Angiogenic markers in breath condensate identify non-small cell lung cancer
Abstract Early recognition of lung cancer is a prerequisite for any strategy to improve lung cancer treatment outcome. Here we report a cross-sectional study intended as a proof of principle investigation using breath based detection (exhaled breath condensate, EBC) of angiogenic markers (VEGF, bFGF...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2010-05, Vol.68 (2), p.177-184 |
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| creator | Gessner, C Rechner, B Hammerschmidt, S Kuhn, H Hoheisel, G Sack, U Ruschpler, P Wirtz, H |
| description | Abstract Early recognition of lung cancer is a prerequisite for any strategy to improve lung cancer treatment outcome. Here we report a cross-sectional study intended as a proof of principle investigation using breath based detection (exhaled breath condensate, EBC) of angiogenic markers (VEGF, bFGF, angiogenin), TNF-α and IL-8 to discriminate 74 individuals, with confirmed presence or absence (X-ray, CT) of non-small lung cancer (NSCLC). Levels of angiogenic markers bFGF, angiogenin and VEGF in EBC significantly discriminated between 17 individuals with newly detected NSCLC versus stable and exacerbated chronic obstructive pulmonary disease (COPD) patients as well as healthy volunteers. Levels of IL-8 and TNF-α in EBC indicated acute inflammation, e.g. in acute exacerbated COPD (AECOPD) and were not indicative of lung cancer. In a different group of patients that were already treated with two cycles of chemotherapy and who responded with at least a 25% reduction in primary tumor diameter, levels of angiogenic markers were lower compared to patients with newly diagnosed NSCLC. We suggest that breath based detection of angiogenic markers may help in the early detection of lung cancer. |
| doi_str_mv | 10.1016/j.lungcan.2009.06.010 |
| format | Article |
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Here we report a cross-sectional study intended as a proof of principle investigation using breath based detection (exhaled breath condensate, EBC) of angiogenic markers (VEGF, bFGF, angiogenin), TNF-α and IL-8 to discriminate 74 individuals, with confirmed presence or absence (X-ray, CT) of non-small lung cancer (NSCLC). Levels of angiogenic markers bFGF, angiogenin and VEGF in EBC significantly discriminated between 17 individuals with newly detected NSCLC versus stable and exacerbated chronic obstructive pulmonary disease (COPD) patients as well as healthy volunteers. Levels of IL-8 and TNF-α in EBC indicated acute inflammation, e.g. in acute exacerbated COPD (AECOPD) and were not indicative of lung cancer. In a different group of patients that were already treated with two cycles of chemotherapy and who responded with at least a 25% reduction in primary tumor diameter, levels of angiogenic markers were lower compared to patients with newly diagnosed NSCLC. We suggest that breath based detection of angiogenic markers may help in the early detection of lung cancer.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2009.06.010</identifier><identifier>PMID: 19647334</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Oxford: Elsevier Ireland Ltd</publisher><subject>Aged ; Angiogenic markers ; Angiogenin ; bFGF ; Biological and medical sciences ; Biomarkers ; Biomarkers, Tumor - analysis ; Breath Tests ; Carcinoma, Non-Small-Cell Lung - blood supply ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - physiopathology ; Cross-Sectional Studies ; Diagnosis, Differential ; Disease Progression ; Exhaled breath condensate ; Feasibility Studies ; Female ; Fibroblast Growth Factors - analysis ; Hematology, Oncology and Palliative Medicine ; Humans ; Lung cancer ; Lung Neoplasms - blood supply ; Lung Neoplasms - diagnosis ; Lung Neoplasms - pathology ; Lung Neoplasms - physiopathology ; Male ; Medical sciences ; Middle Aged ; Multiplex bead based immunoassay ; Neovascularization, Pathologic ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary/Respiratory ; Ribonuclease, Pancreatic - analysis ; Tumors ; Tumors of the respiratory system and mediastinum ; Vascular Endothelial Growth Factor A - analysis ; VEGF</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2010-05, Vol.68 (2), p.177-184</ispartof><rights>2009</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009. 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Here we report a cross-sectional study intended as a proof of principle investigation using breath based detection (exhaled breath condensate, EBC) of angiogenic markers (VEGF, bFGF, angiogenin), TNF-α and IL-8 to discriminate 74 individuals, with confirmed presence or absence (X-ray, CT) of non-small lung cancer (NSCLC). Levels of angiogenic markers bFGF, angiogenin and VEGF in EBC significantly discriminated between 17 individuals with newly detected NSCLC versus stable and exacerbated chronic obstructive pulmonary disease (COPD) patients as well as healthy volunteers. Levels of IL-8 and TNF-α in EBC indicated acute inflammation, e.g. in acute exacerbated COPD (AECOPD) and were not indicative of lung cancer. In a different group of patients that were already treated with two cycles of chemotherapy and who responded with at least a 25% reduction in primary tumor diameter, levels of angiogenic markers were lower compared to patients with newly diagnosed NSCLC. We suggest that breath based detection of angiogenic markers may help in the early detection of lung cancer.</description><subject>Aged</subject><subject>Angiogenic markers</subject><subject>Angiogenin</subject><subject>bFGF</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Breath Tests</subject><subject>Carcinoma, Non-Small-Cell Lung - blood supply</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis, Differential</subject><subject>Disease Progression</subject><subject>Exhaled breath condensate</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fibroblast Growth Factors - analysis</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiplex bead based immunoassay</subject><subject>Neovascularization, Pathologic</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary/Respiratory</subject><subject>Ribonuclease, Pancreatic - analysis</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Vascular Endothelial Growth Factor A - analysis</subject><subject>VEGF</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCI4ByQZwSxnbWji-gqmoLolIPhbNlO-PF26xT7ARp3x5HG4HEhYvtwzfjf74h5A2FhgIVH_bNMMedM7FhAKoB0QCFZ2RDO8nqjnP2nGwKp-otADsj5znvAaikoF6SM6pEKzlvN-TrZdyFcYcxuOpg0iOmXIVY2YRm-lG5MfYYs5mwCuUxBX-s4hjrfDDDUDksx5KiKjEcplfkhTdDxtfrfUG-31x_u_pc393ffrm6vKtd26qpNhaEF115e6-Utb4VtuVWtmCk67kX7VYCM9arnlNUEjs0PeO97y1YLzi_IO9PfZ_S-HPGPOlDyEsYE3Gcsy6TdbyTUhVyeyJdGnNO6PVTCmXMo6agF416r1eNetGoQeiisdS9XX-Y7QH7v1WrtwK8WwGTnRl8KgJC_sMxJihVaon66cRh8fErYNLZBSyy-pDQTbofw3-jfPyngxtC2ZYZHvGIeT_OKRbZmurMNOiHZefLykEBlKSU_wYDxajJ</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Gessner, C</creator><creator>Rechner, B</creator><creator>Hammerschmidt, S</creator><creator>Kuhn, H</creator><creator>Hoheisel, G</creator><creator>Sack, U</creator><creator>Ruschpler, P</creator><creator>Wirtz, H</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Angiogenic markers in breath condensate identify non-small cell lung cancer</title><author>Gessner, C ; Rechner, B ; Hammerschmidt, S ; Kuhn, H ; Hoheisel, G ; Sack, U ; Ruschpler, P ; Wirtz, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-ab06f68449ff99bbf46b43b740a7cd3f645702abf9d31e97e8ead23dfdb0bf633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Angiogenic markers</topic><topic>Angiogenin</topic><topic>bFGF</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Breath Tests</topic><topic>Carcinoma, Non-Small-Cell Lung - blood supply</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis, Differential</topic><topic>Disease Progression</topic><topic>Exhaled breath condensate</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fibroblast Growth Factors - analysis</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiplex bead based immunoassay</topic><topic>Neovascularization, Pathologic</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary/Respiratory</topic><topic>Ribonuclease, Pancreatic - analysis</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Vascular Endothelial Growth Factor A - analysis</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gessner, C</creatorcontrib><creatorcontrib>Rechner, B</creatorcontrib><creatorcontrib>Hammerschmidt, S</creatorcontrib><creatorcontrib>Kuhn, H</creatorcontrib><creatorcontrib>Hoheisel, G</creatorcontrib><creatorcontrib>Sack, U</creatorcontrib><creatorcontrib>Ruschpler, P</creatorcontrib><creatorcontrib>Wirtz, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gessner, C</au><au>Rechner, B</au><au>Hammerschmidt, S</au><au>Kuhn, H</au><au>Hoheisel, G</au><au>Sack, U</au><au>Ruschpler, P</au><au>Wirtz, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiogenic markers in breath condensate identify non-small cell lung cancer</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>68</volume><issue>2</issue><spage>177</spage><epage>184</epage><pages>177-184</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><coden>LUCAE5</coden><abstract>Abstract Early recognition of lung cancer is a prerequisite for any strategy to improve lung cancer treatment outcome. Here we report a cross-sectional study intended as a proof of principle investigation using breath based detection (exhaled breath condensate, EBC) of angiogenic markers (VEGF, bFGF, angiogenin), TNF-α and IL-8 to discriminate 74 individuals, with confirmed presence or absence (X-ray, CT) of non-small lung cancer (NSCLC). Levels of angiogenic markers bFGF, angiogenin and VEGF in EBC significantly discriminated between 17 individuals with newly detected NSCLC versus stable and exacerbated chronic obstructive pulmonary disease (COPD) patients as well as healthy volunteers. Levels of IL-8 and TNF-α in EBC indicated acute inflammation, e.g. in acute exacerbated COPD (AECOPD) and were not indicative of lung cancer. In a different group of patients that were already treated with two cycles of chemotherapy and who responded with at least a 25% reduction in primary tumor diameter, levels of angiogenic markers were lower compared to patients with newly diagnosed NSCLC. We suggest that breath based detection of angiogenic markers may help in the early detection of lung cancer.</abstract><cop>Oxford</cop><pub>Elsevier Ireland Ltd</pub><pmid>19647334</pmid><doi>10.1016/j.lungcan.2009.06.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Angiogenic markers Angiogenin bFGF Biological and medical sciences Biomarkers Biomarkers, Tumor - analysis Breath Tests Carcinoma, Non-Small-Cell Lung - blood supply Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - physiopathology Cross-Sectional Studies Diagnosis, Differential Disease Progression Exhaled breath condensate Feasibility Studies Female Fibroblast Growth Factors - analysis Hematology, Oncology and Palliative Medicine Humans Lung cancer Lung Neoplasms - blood supply Lung Neoplasms - diagnosis Lung Neoplasms - pathology Lung Neoplasms - physiopathology Male Medical sciences Middle Aged Multiplex bead based immunoassay Neovascularization, Pathologic Pneumology Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary/Respiratory Ribonuclease, Pancreatic - analysis Tumors Tumors of the respiratory system and mediastinum Vascular Endothelial Growth Factor A - analysis VEGF |
| title | Angiogenic markers in breath condensate identify non-small cell lung cancer |
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