Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24

R24, a mouse IgG3 monoclonal antibody (MAb) against ganglioside GD3 (Neu5Acα8Neu5Acα3Gal β4Glcβ1Cer), can block tumor growth as reported in a series of clinical trials in patients with metastatic melanoma. The IgG molecule basically contains an asparagine‐linked biantennary complex type oligosacchar...

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Veröffentlicht in:	Biotechnology and bioengineering 2003-08, Vol.83 (3), p.321-334
Hauptverfasser:	Müthing, Johannes, Kemminer, Sven E., Conradt, Harald S., Šagi, Dijana, Nimtz, Manfred, Kärst, Uwe, Peter-Katalinić, Jasna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Biological and medical sciences Biotechnology Cell Culture Techniques - methods cell culture technology Cell Division - drug effects Cell Line Culture Media - chemistry Culture Media - pharmacology Fundamental and applied biological sciences. Psychology ganglioside GD3 glycoproteins Glycosylation - drug effects Health. Pharmaceutical industry Hybridomas - cytology Hybridomas - drug effects Hybridomas - immunology Hybridomas - metabolism Hydrogen-Ion Concentration Immunoglobulin G - biosynthesis Immunoglobulin G - immunology immunotherapy Industrial applications and implications. Economical aspects Mice Monoclonal antibodies N-glycans nanoESI-QTOF MS Production of active biomolecules Quality Control sialic acids
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