Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs

Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In most cases, neoplastic cells display the D816V-mutated variant of KIT. KIT D816V exhibits constitutive tyrosine kinase (TK) activity and has been implicated in increased survival and growth of neopl...

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Veröffentlicht in:	Blood 2009-12, Vol.114 (26), p.5342-5351
Hauptverfasser:	Aichberger, Karl J., Gleixner, Karoline V., Mirkina, Irina, Cerny-Reiterer, Sabine, Peter, Barbara, Ferenc, Veronika, Kneidinger, Michael, Baumgartner, Christian, Mayerhofer, Matthias, Gruze, Alexander, Pickl, Winfried F., Sillaber, Christian, Valent, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 Blotting, Northern Blotting, Western Boronic Acids - pharmacology Bortezomib Flow Cytometry Gene Expression Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans Immunohistochemistry In Situ Nick-End Labeling Mast Cells - drug effects Mast Cells - metabolism Mast Cells - pathology Mastocytosis, Systemic - drug therapy Mastocytosis, Systemic - genetics Mastocytosis, Systemic - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-kit - genetics Pyrazines - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Staurosporine - analogs & derivatives Staurosporine - pharmacology Transfection
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