Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles
Abstract Background The objective of this study was to evaluate the effects of a contraceptive pill containing ethinylestradiol (30 mcg) and drospirenone (3 mg) in a continuous regimen on lipid, carbohydrate and coagulation parameters. Study Design This open, prospective, randomized study included 7...
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| Veröffentlicht in: | Contraception (Stoneham) 2010-02, Vol.81 (2), p.102-106 |
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| creator | Machado, Rogério Bonassi de Melo, Nilson Roberto Maia, Hugo Cruz, Achilles Machado |
| description | Abstract Background The objective of this study was to evaluate the effects of a contraceptive pill containing ethinylestradiol (30 mcg) and drospirenone (3 mg) in a continuous regimen on lipid, carbohydrate and coagulation parameters. Study Design This open, prospective, randomized study included 78 participants (mean age 27.8 years) who were randomized into two groups to use the pill continuously for 168 days or for six 28-day cycles with a 7-day hormone-free interval between cycles. Markers of lipid, carbohydrate and coagulation profiles were measured prior to initiation and after the 6 months of pill use. Results No statistically significant differences were found between the two contraceptive regimens with respect to carbohydrate or lipid profiles or in the parameters related to coagulation. Conclusions The contraceptive combination of ethinylestradiol and drospirenone used in a continuous regimen was associated with metabolic alterations similar to those found during the traditional cyclic regimen of oral contraceptive use. |
| doi_str_mv | 10.1016/j.contraception.2009.08.009 |
| format | Article |
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Study Design This open, prospective, randomized study included 78 participants (mean age 27.8 years) who were randomized into two groups to use the pill continuously for 168 days or for six 28-day cycles with a 7-day hormone-free interval between cycles. Markers of lipid, carbohydrate and coagulation profiles were measured prior to initiation and after the 6 months of pill use. Results No statistically significant differences were found between the two contraceptive regimens with respect to carbohydrate or lipid profiles or in the parameters related to coagulation. Conclusions The contraceptive combination of ethinylestradiol and drospirenone used in a continuous regimen was associated with metabolic alterations similar to those found during the traditional cyclic regimen of oral contraceptive use.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2009.08.009</identifier><identifier>PMID: 20103445</identifier><identifier>CODEN: CCPTAY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Analysis of Variance ; Androstenes - administration & dosage ; Androstenes - adverse effects ; Biological and medical sciences ; Birth control ; Blood coagulation ; Blood Coagulation - drug effects ; Blood Coagulation Tests ; Blood Glucose - metabolism ; Continuous use ; Contraceptives, Oral - administration & dosage ; Contraceptives, Oral - adverse effects ; Drospirenone ; Drug Administration Schedule ; Drug Combinations ; Ethinyl Estradiol - administration & dosage ; Ethinyl Estradiol - adverse effects ; Ethinylestradiol ; Female ; Genital system. Reproduction ; Gynecology. Andrology. Obstetrics ; Hormonal contraception ; Humans ; Insulin - blood ; Intention to Treat Analysis ; Lipids - blood ; Medical sciences ; Metabolic profile ; Obstetrics and Gynecology ; Oral contraceptive ; Patient Selection ; Pharmacology. Drug treatments ; Prospective Studies ; Statistics, Nonparametric</subject><ispartof>Contraception (Stoneham), 2010-02, Vol.81 (2), p.102-106</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-fedb879a9a708a17e301c978f7f02426103bc88cd521fa850a2c7d6d83cefdb73</citedby><cites>FETCH-LOGICAL-c467t-fedb879a9a708a17e301c978f7f02426103bc88cd521fa850a2c7d6d83cefdb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0010782409003886$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22352978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20103445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machado, Rogério Bonassi</creatorcontrib><creatorcontrib>de Melo, Nilson Roberto</creatorcontrib><creatorcontrib>Maia, Hugo</creatorcontrib><creatorcontrib>Cruz, Achilles Machado</creatorcontrib><title>Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Background The objective of this study was to evaluate the effects of a contraceptive pill containing ethinylestradiol (30 mcg) and drospirenone (3 mg) in a continuous regimen on lipid, carbohydrate and coagulation parameters. Study Design This open, prospective, randomized study included 78 participants (mean age 27.8 years) who were randomized into two groups to use the pill continuously for 168 days or for six 28-day cycles with a 7-day hormone-free interval between cycles. Markers of lipid, carbohydrate and coagulation profiles were measured prior to initiation and after the 6 months of pill use. Results No statistically significant differences were found between the two contraceptive regimens with respect to carbohydrate or lipid profiles or in the parameters related to coagulation. Conclusions The contraceptive combination of ethinylestradiol and drospirenone used in a continuous regimen was associated with metabolic alterations similar to those found during the traditional cyclic regimen of oral contraceptive use.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Androstenes - administration & dosage</subject><subject>Androstenes - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Blood coagulation</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood Coagulation Tests</subject><subject>Blood Glucose - metabolism</subject><subject>Continuous use</subject><subject>Contraceptives, Oral - administration & dosage</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Drospirenone</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations</subject><subject>Ethinyl Estradiol - administration & dosage</subject><subject>Ethinyl Estradiol - adverse effects</subject><subject>Ethinylestradiol</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormonal contraception</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Intention to Treat Analysis</subject><subject>Lipids - blood</subject><subject>Medical sciences</subject><subject>Metabolic profile</subject><subject>Obstetrics and Gynecology</subject><subject>Oral contraceptive</subject><subject>Patient Selection</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Statistics, Nonparametric</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuKFDEQhhtR3NnVV5AGEW_sttKnpBEEWWZVWPBCvQ7ppLKbsTsZk-6FeQsf2WpnPF55VST56v9Thyx7yqBkwLqXu1IHP0elcT-74MsKoC9BlBTuZRsmeF9Ay8T9bAPAoOCias6y85R2AMD7lj_Mzip6qJum3WTfttainvNgc5Wvus4vYUl5xBs3oV_v_3C7QzpNg_NqdV4fcb51_jBiIsS4MObKm9zEkPYuog8ec-JGt3fmRa5VHMLtwUQ14w9OB3WzjEetfQzWkc6j7IFVY8LHp3iRfb7afrp8V1x_ePv-8s11oZuOz4VFM1ClqlcchGIca2C658JyC1VTdVTfoIXQpq2YVaIFVWluOiNqjdYMvL7Inh91yfjrQv-Xk0sax1F5pAZIXtei5tC0RL46kprKShGt3Ec3qXiQDOQ6EbmTf01ErhORICQFyn5y8lmGCc2v3J8jIODZCVBJq9FG5bVLv7mqbisqjLjtkUPqyp3DKJN26DUa6rSepQnuPz_0-h8dPTrvyPoLHjDtwhI9NV4ymSoJ8uO6ROsOQQ9QC9HV3wFkvssF</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Machado, Rogério Bonassi</creator><creator>de Melo, Nilson Roberto</creator><creator>Maia, Hugo</creator><creator>Cruz, Achilles Machado</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles</title><author>Machado, Rogério Bonassi ; de Melo, Nilson Roberto ; Maia, Hugo ; Cruz, Achilles Machado</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-fedb879a9a708a17e301c978f7f02426103bc88cd521fa850a2c7d6d83cefdb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Androstenes - administration & dosage</topic><topic>Androstenes - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Blood coagulation</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood Coagulation Tests</topic><topic>Blood Glucose - metabolism</topic><topic>Continuous use</topic><topic>Contraceptives, Oral - administration & dosage</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>Drospirenone</topic><topic>Drug Administration Schedule</topic><topic>Drug Combinations</topic><topic>Ethinyl Estradiol - administration & dosage</topic><topic>Ethinyl Estradiol - adverse effects</topic><topic>Ethinylestradiol</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormonal contraception</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Intention to Treat Analysis</topic><topic>Lipids - blood</topic><topic>Medical sciences</topic><topic>Metabolic profile</topic><topic>Obstetrics and Gynecology</topic><topic>Oral contraceptive</topic><topic>Patient Selection</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machado, Rogério Bonassi</creatorcontrib><creatorcontrib>de Melo, Nilson Roberto</creatorcontrib><creatorcontrib>Maia, Hugo</creatorcontrib><creatorcontrib>Cruz, Achilles Machado</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machado, Rogério Bonassi</au><au>de Melo, Nilson Roberto</au><au>Maia, Hugo</au><au>Cruz, Achilles Machado</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>81</volume><issue>2</issue><spage>102</spage><epage>106</epage><pages>102-106</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>Abstract Background The objective of this study was to evaluate the effects of a contraceptive pill containing ethinylestradiol (30 mcg) and drospirenone (3 mg) in a continuous regimen on lipid, carbohydrate and coagulation parameters. Study Design This open, prospective, randomized study included 78 participants (mean age 27.8 years) who were randomized into two groups to use the pill continuously for 168 days or for six 28-day cycles with a 7-day hormone-free interval between cycles. Markers of lipid, carbohydrate and coagulation profiles were measured prior to initiation and after the 6 months of pill use. Results No statistically significant differences were found between the two contraceptive regimens with respect to carbohydrate or lipid profiles or in the parameters related to coagulation. Conclusions The contraceptive combination of ethinylestradiol and drospirenone used in a continuous regimen was associated with metabolic alterations similar to those found during the traditional cyclic regimen of oral contraceptive use.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20103445</pmid><doi>10.1016/j.contraception.2009.08.009</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Analysis of Variance Androstenes - administration & dosage Androstenes - adverse effects Biological and medical sciences Birth control Blood coagulation Blood Coagulation - drug effects Blood Coagulation Tests Blood Glucose - metabolism Continuous use Contraceptives, Oral - administration & dosage Contraceptives, Oral - adverse effects Drospirenone Drug Administration Schedule Drug Combinations Ethinyl Estradiol - administration & dosage Ethinyl Estradiol - adverse effects Ethinylestradiol Female Genital system. Reproduction Gynecology. Andrology. Obstetrics Hormonal contraception Humans Insulin - blood Intention to Treat Analysis Lipids - blood Medical sciences Metabolic profile Obstetrics and Gynecology Oral contraceptive Patient Selection Pharmacology. Drug treatments Prospective Studies Statistics, Nonparametric |
| title | Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles |
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