Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients
To test the hypothesis that impaired expression of the thiosulfate sulfurtransferase rhodanese is associated with oxidative stress and may predict mortality in hemodialysis patients. Sixty-two hemodialysis patients were investigated to determine protein and mRNA expression of rhodanese in monocytes....
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| Veröffentlicht in: | Clinical biochemistry 2010, Vol.43 (1), p.95-101 |
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| creator | Krueger, Katharina Koch, Kathrin Jühling, Anja Tepel, Martin Scholze, Alexandra |
| description | To test the hypothesis that impaired expression of the thiosulfate sulfurtransferase rhodanese is associated with oxidative stress and may predict mortality in hemodialysis patients.
Sixty-two hemodialysis patients were investigated to determine protein and mRNA expression of rhodanese in monocytes. Whole cell reactive oxygen species and mitochondrial superoxide production were measured by fluorescence spectrophotometry.
Compared to healthy subjects, hemodialysis patients showed significantly lower rhodanese mRNA and protein expression and significantly increased reactive oxygen species. Lower rhodanese protein expression was significantly associated with higher mitochondrial superoxide production. The hazard ratio for mortality in hemodialysis patients with rhodanese mRNA below compared to patients above the median was 2.22. Survival was shorter with rhodanese mRNA below compared to patients above the median.
Impaired rhodanese expression is associated with increased whole cell reactive oxygen species as well as higher mitochondrial superoxide production and predicts mortality in hemodialysis patients. |
| doi_str_mv | 10.1016/j.clinbiochem.2009.08.005 |
| format | Article |
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Sixty-two hemodialysis patients were investigated to determine protein and mRNA expression of rhodanese in monocytes. Whole cell reactive oxygen species and mitochondrial superoxide production were measured by fluorescence spectrophotometry.
Compared to healthy subjects, hemodialysis patients showed significantly lower rhodanese mRNA and protein expression and significantly increased reactive oxygen species. Lower rhodanese protein expression was significantly associated with higher mitochondrial superoxide production. The hazard ratio for mortality in hemodialysis patients with rhodanese mRNA below compared to patients above the median was 2.22. Survival was shorter with rhodanese mRNA below compared to patients above the median.
Impaired rhodanese expression is associated with increased whole cell reactive oxygen species as well as higher mitochondrial superoxide production and predicts mortality in hemodialysis patients.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2009.08.005</identifier><identifier>PMID: 19695240</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Hemodialysis ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Mitochondria - metabolism ; Monocytes - enzymology ; Mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Oxidative Stress ; Patients with chronic kidney disease stage 5 ; Pregnancy ; Reactive Oxygen Species - metabolism ; Renal Dialysis - mortality ; Renal failure ; Rhodanese ; Superoxides - metabolism ; Thiosulfate Sulfurtransferase - genetics ; Thiosulfate Sulfurtransferase - metabolism ; Uremia ; Young Adult</subject><ispartof>Clinical biochemistry, 2010, Vol.43 (1), p.95-101</ispartof><rights>2009 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-61a807b7cbf3254e4f4e3f24dd4f1a5e83967676d22e622875cd01c34c99aac93</citedby><cites>FETCH-LOGICAL-c406t-61a807b7cbf3254e4f4e3f24dd4f1a5e83967676d22e622875cd01c34c99aac93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2009.08.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22341537$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19695240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krueger, Katharina</creatorcontrib><creatorcontrib>Koch, Kathrin</creatorcontrib><creatorcontrib>Jühling, Anja</creatorcontrib><creatorcontrib>Tepel, Martin</creatorcontrib><creatorcontrib>Scholze, Alexandra</creatorcontrib><title>Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>To test the hypothesis that impaired expression of the thiosulfate sulfurtransferase rhodanese is associated with oxidative stress and may predict mortality in hemodialysis patients.
Sixty-two hemodialysis patients were investigated to determine protein and mRNA expression of rhodanese in monocytes. Whole cell reactive oxygen species and mitochondrial superoxide production were measured by fluorescence spectrophotometry.
Compared to healthy subjects, hemodialysis patients showed significantly lower rhodanese mRNA and protein expression and significantly increased reactive oxygen species. Lower rhodanese protein expression was significantly associated with higher mitochondrial superoxide production. The hazard ratio for mortality in hemodialysis patients with rhodanese mRNA below compared to patients above the median was 2.22. Survival was shorter with rhodanese mRNA below compared to patients above the median.
Impaired rhodanese expression is associated with increased whole cell reactive oxygen species as well as higher mitochondrial superoxide production and predicts mortality in hemodialysis patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitochondria - metabolism</subject><subject>Monocytes - enzymology</subject><subject>Mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Oxidative Stress</subject><subject>Patients with chronic kidney disease stage 5</subject><subject>Pregnancy</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Renal Dialysis - mortality</subject><subject>Renal failure</subject><subject>Rhodanese</subject><subject>Superoxides - metabolism</subject><subject>Thiosulfate Sulfurtransferase - genetics</subject><subject>Thiosulfate Sulfurtransferase - metabolism</subject><subject>Uremia</subject><subject>Young Adult</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEURi0EomnhLyCzQC2LGfyah5dVxEuKxKZdW47nmjiaGQdfDzT_HkeJgCXy4sry-Xw_HULeclZzxtsP-9qNYd6G6HYw1YIxXbO-Zqx5Rla872QltJTPyYqVl0pzwa7INeK-XIXq25fkiutWN0KxFfm-ib8oPB0SIIY40-hp3oWIy-htBnqaS8rJzughWQR6l3ZxsDMgvKclNQSXkU4xZTuGfKRhpqVTHIIdjxiQHmwOMGd8RV54OyK8vswb8vjp48P6S7X59vnr-n5TOcXaXLXc9qzbdm7rpWgUKK9AeqGGQXluG-ilbrtyBiGgFaLvGjcw7qRyWlvrtLwht-d_Dyn-WACzmQI6GMdSOS5oOil7qWTDCqnPpEsRMYE3hxQmm46GM3PSbPbmH83mpNmw3hTNJfvmsmXZTjD8TV68FuDdBbDo7OiLQBfwDyeEVLyRXeHWZw6Kk58BkkFXfLniNYHLZojhP-r8BrLbo88</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Krueger, Katharina</creator><creator>Koch, Kathrin</creator><creator>Jühling, Anja</creator><creator>Tepel, Martin</creator><creator>Scholze, Alexandra</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients</title><author>Krueger, Katharina ; Koch, Kathrin ; Jühling, Anja ; Tepel, Martin ; Scholze, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-61a807b7cbf3254e4f4e3f24dd4f1a5e83967676d22e622875cd01c34c99aac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitochondria - metabolism</topic><topic>Monocytes - enzymology</topic><topic>Mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Oxidative Stress</topic><topic>Patients with chronic kidney disease stage 5</topic><topic>Pregnancy</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Renal Dialysis - mortality</topic><topic>Renal failure</topic><topic>Rhodanese</topic><topic>Superoxides - metabolism</topic><topic>Thiosulfate Sulfurtransferase - genetics</topic><topic>Thiosulfate Sulfurtransferase - metabolism</topic><topic>Uremia</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krueger, Katharina</creatorcontrib><creatorcontrib>Koch, Kathrin</creatorcontrib><creatorcontrib>Jühling, Anja</creatorcontrib><creatorcontrib>Tepel, Martin</creatorcontrib><creatorcontrib>Scholze, Alexandra</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krueger, Katharina</au><au>Koch, Kathrin</au><au>Jühling, Anja</au><au>Tepel, Martin</au><au>Scholze, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2010</date><risdate>2010</risdate><volume>43</volume><issue>1</issue><spage>95</spage><epage>101</epage><pages>95-101</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>To test the hypothesis that impaired expression of the thiosulfate sulfurtransferase rhodanese is associated with oxidative stress and may predict mortality in hemodialysis patients.
Sixty-two hemodialysis patients were investigated to determine protein and mRNA expression of rhodanese in monocytes. Whole cell reactive oxygen species and mitochondrial superoxide production were measured by fluorescence spectrophotometry.
Compared to healthy subjects, hemodialysis patients showed significantly lower rhodanese mRNA and protein expression and significantly increased reactive oxygen species. Lower rhodanese protein expression was significantly associated with higher mitochondrial superoxide production. The hazard ratio for mortality in hemodialysis patients with rhodanese mRNA below compared to patients above the median was 2.22. Survival was shorter with rhodanese mRNA below compared to patients above the median.
Impaired rhodanese expression is associated with increased whole cell reactive oxygen species as well as higher mitochondrial superoxide production and predicts mortality in hemodialysis patients.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19695240</pmid><doi>10.1016/j.clinbiochem.2009.08.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management Female Hemodialysis Humans Intensive care medicine Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Mitochondria - metabolism Monocytes - enzymology Mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Oxidative Stress Patients with chronic kidney disease stage 5 Pregnancy Reactive Oxygen Species - metabolism Renal Dialysis - mortality Renal failure Rhodanese Superoxides - metabolism Thiosulfate Sulfurtransferase - genetics Thiosulfate Sulfurtransferase - metabolism Uremia Young Adult |
| title | Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients |
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