Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia

Abstract Although intravenous delivery of mesenchymal stem cells (MSCs) prepared from adult bone marrow reduces infarction size and ameliorates functional deficits in rat middle cerebral artery occlusion models, there are few reports of MSC treatment in global cerebral ischemia. We utilized a global...

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Veröffentlicht in:	Brain research 2010-01, Vol.1310, p.8-16
Hauptverfasser:	Zheng, Wei, Honmou, Osamu, Miyata, Kei, Harada, Kuniaki, Suzuki, Junpei, Liu, He, Houkin, Kiyohiro, Hamada, Hirofumi, Kocsis, Jeffery D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Bone marrow Bone Marrow Cells - physiology Brain Ischemia - complications Brain Ischemia - surgery Brain-Derived Neurotrophic Factor - metabolism Cardiac arrest Cell Count - methods Creatine - metabolism Disease Models, Animal Global cerebral ischemia Heart Arrest - etiology Heart Arrest - therapy Humans In Situ Nick-End Labeling - methods Lactic Acid - metabolism Magnetic Resonance Imaging - methods Male Maze Learning - physiology Medical sciences Mesenchymal Stem Cell Transplantation - methods Neurology Neuroprotection Rats Rats, Wistar Regeneration Time Factors Transplantation Vascular diseases and vascular malformations of the nervous system
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