Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans
We investigated whether a structured medium- and long-chain triacylglycerols (MLCT) diet could decrease accumulation of body fat in healthy humans. The study was conducted under a double-blind randomized design. Ninety-three subjects participated in this study. However, 10 subjects could not consume...
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| Veröffentlicht in: | Asia Pacific journal of clinical nutrition 2003, Vol.12 (2), p.151-160 |
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| creator | Kasai, Michio Nosaka, Naohisa Maki, Hideaki Negishi, Satoshi Aoyama, Toshiaki Nakamura, Masahiro Suzuki, Yoshie Tsuji, Hiroaki Uto, Harumi Okazaki, Mitsuko Kondo, Kazuo |
| description | We investigated whether a structured medium- and long-chain triacylglycerols (MLCT) diet could decrease accumulation of body fat in healthy humans. The study was conducted under a double-blind randomized design. Ninety-three subjects participated in this study. However, 10 subjects could not consume the specified meal, and one subject wished to opt out. Consequently, the study included 82 subjects. The experimental subjects consumed the test bread, which was made with 14 g of MLCT containing 1.7 g MCFA, daily at breakfast during the study period of 12 weeks, and the control subjects consumed bread made with long-chain triacylglycerols (LCT). All subjects consumed the same standard packaged meals. Body composition parameters were body weight, total body fat and abdominal fat, and blood analyses included serum cholesterol, triacylglycerols and phospholipids. Significant decreases of body weight, the amount of body fat, subcutaneous and visceral fat were noted in the MLCT group as compared with those of the LCT group for 12 weeks (P |
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The study was conducted under a double-blind randomized design. Ninety-three subjects participated in this study. However, 10 subjects could not consume the specified meal, and one subject wished to opt out. Consequently, the study included 82 subjects. The experimental subjects consumed the test bread, which was made with 14 g of MLCT containing 1.7 g MCFA, daily at breakfast during the study period of 12 weeks, and the control subjects consumed bread made with long-chain triacylglycerols (LCT). All subjects consumed the same standard packaged meals. Body composition parameters were body weight, total body fat and abdominal fat, and blood analyses included serum cholesterol, triacylglycerols and phospholipids. Significant decreases of body weight, the amount of body fat, subcutaneous and visceral fat were noted in the MLCT group as compared with those of the LCT group for 12 weeks (P<0.05). Furthermore, a significant decrease in serum total cholesterol was noted in the MLCT group as compared with that of the LCT group at 8 weeks (P<0.05). However, other serum parameters were not different between the MLCT and LCT groups. The results suggest that the daily intake of MLCT diet could result in a reduction in body weight and in accumulation of body fat, and, moreover, it could reduce serum total cholesterol.</description><identifier>ISSN: 0964-7058</identifier><identifier>PMID: 12810404</identifier><language>eng</language><publisher>Australia</publisher><subject>Adipose Tissue - growth & development ; Adipose Tissue - metabolism ; Adult ; Body Composition - drug effects ; Body Composition - physiology ; Body Constitution - physiology ; Body Mass Index ; Body Weight - drug effects ; Cholesterol - blood ; Dietary Fats - administration & dosage ; Dietary Fats - metabolism ; Double-Blind Method ; Energy Metabolism ; Humans ; Middle Aged ; Obesity - diet therapy ; Obesity - metabolism ; Obesity - prevention & control ; Phospholipids - blood ; Triglycerides - administration & dosage ; Triglycerides - chemistry ; Triglycerides - metabolism ; Weight Loss</subject><ispartof>Asia Pacific journal of clinical nutrition, 2003, Vol.12 (2), p.151-160</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,4026</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12810404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasai, Michio</creatorcontrib><creatorcontrib>Nosaka, Naohisa</creatorcontrib><creatorcontrib>Maki, Hideaki</creatorcontrib><creatorcontrib>Negishi, Satoshi</creatorcontrib><creatorcontrib>Aoyama, Toshiaki</creatorcontrib><creatorcontrib>Nakamura, Masahiro</creatorcontrib><creatorcontrib>Suzuki, Yoshie</creatorcontrib><creatorcontrib>Tsuji, Hiroaki</creatorcontrib><creatorcontrib>Uto, Harumi</creatorcontrib><creatorcontrib>Okazaki, Mitsuko</creatorcontrib><creatorcontrib>Kondo, Kazuo</creatorcontrib><title>Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans</title><title>Asia Pacific journal of clinical nutrition</title><addtitle>Asia Pac J Clin Nutr</addtitle><description>We investigated whether a structured medium- and long-chain triacylglycerols (MLCT) diet could decrease accumulation of body fat in healthy humans. The study was conducted under a double-blind randomized design. Ninety-three subjects participated in this study. However, 10 subjects could not consume the specified meal, and one subject wished to opt out. Consequently, the study included 82 subjects. The experimental subjects consumed the test bread, which was made with 14 g of MLCT containing 1.7 g MCFA, daily at breakfast during the study period of 12 weeks, and the control subjects consumed bread made with long-chain triacylglycerols (LCT). All subjects consumed the same standard packaged meals. Body composition parameters were body weight, total body fat and abdominal fat, and blood analyses included serum cholesterol, triacylglycerols and phospholipids. Significant decreases of body weight, the amount of body fat, subcutaneous and visceral fat were noted in the MLCT group as compared with those of the LCT group for 12 weeks (P<0.05). Furthermore, a significant decrease in serum total cholesterol was noted in the MLCT group as compared with that of the LCT group at 8 weeks (P<0.05). However, other serum parameters were not different between the MLCT and LCT groups. The results suggest that the daily intake of MLCT diet could result in a reduction in body weight and in accumulation of body fat, and, moreover, it could reduce serum total cholesterol.</description><subject>Adipose Tissue - growth & development</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Body Composition - drug effects</subject><subject>Body Composition - physiology</subject><subject>Body Constitution - physiology</subject><subject>Body Mass Index</subject><subject>Body Weight - drug effects</subject><subject>Cholesterol - blood</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - metabolism</subject><subject>Double-Blind Method</subject><subject>Energy Metabolism</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Obesity - diet therapy</subject><subject>Obesity - metabolism</subject><subject>Obesity - prevention & control</subject><subject>Phospholipids - blood</subject><subject>Triglycerides - administration & dosage</subject><subject>Triglycerides - chemistry</subject><subject>Triglycerides - metabolism</subject><subject>Weight Loss</subject><issn>0964-7058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD1PwzAYhD2AaCn8BeQJwRDJiZ3YGVFVKFIRS5mj1x9pjBy7xPaQf08kynQ66bmT7q7QmrQNKzipxQrdxvhNCKGM1DdoVVaiJIywNfK7vjcq4dBjbU2Cacaj0TaPBQavsQv-VKgBrMdpsqBmd3KzMlNwET99HLbHZxw8BqXymB0ku5ilSQY94x4SXmKDAZeGGQ95BB_v0HUPLpr7i27Q1-vuuN0Xh8-39-3LoThXhKfC8IZRWcveNC2vZGm4rGTFhFaaMClKDUzSqiElbQThXLbQaCFqaI3SihNFN-jxr_c8hZ9sYupGG5VxDrwJOXacUkEp5Qv4cAGzXIZ358mOywnd_0P0F5reYbQ</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Kasai, Michio</creator><creator>Nosaka, Naohisa</creator><creator>Maki, Hideaki</creator><creator>Negishi, Satoshi</creator><creator>Aoyama, Toshiaki</creator><creator>Nakamura, Masahiro</creator><creator>Suzuki, Yoshie</creator><creator>Tsuji, Hiroaki</creator><creator>Uto, Harumi</creator><creator>Okazaki, Mitsuko</creator><creator>Kondo, Kazuo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans</title><author>Kasai, Michio ; Nosaka, Naohisa ; Maki, Hideaki ; Negishi, Satoshi ; Aoyama, Toshiaki ; Nakamura, Masahiro ; Suzuki, Yoshie ; Tsuji, Hiroaki ; Uto, Harumi ; Okazaki, Mitsuko ; Kondo, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p207t-e7643b5bfe6972b1e7b2b248dcd04b81da4b32601368077b9a6d885a9ecdc70c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adipose Tissue - growth & development</topic><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Body Composition - drug effects</topic><topic>Body Composition - physiology</topic><topic>Body Constitution - physiology</topic><topic>Body Mass Index</topic><topic>Body Weight - drug effects</topic><topic>Cholesterol - blood</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - metabolism</topic><topic>Double-Blind Method</topic><topic>Energy Metabolism</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Obesity - diet therapy</topic><topic>Obesity - metabolism</topic><topic>Obesity - prevention & control</topic><topic>Phospholipids - blood</topic><topic>Triglycerides - administration & dosage</topic><topic>Triglycerides - chemistry</topic><topic>Triglycerides - metabolism</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasai, Michio</creatorcontrib><creatorcontrib>Nosaka, Naohisa</creatorcontrib><creatorcontrib>Maki, Hideaki</creatorcontrib><creatorcontrib>Negishi, Satoshi</creatorcontrib><creatorcontrib>Aoyama, Toshiaki</creatorcontrib><creatorcontrib>Nakamura, Masahiro</creatorcontrib><creatorcontrib>Suzuki, Yoshie</creatorcontrib><creatorcontrib>Tsuji, Hiroaki</creatorcontrib><creatorcontrib>Uto, Harumi</creatorcontrib><creatorcontrib>Okazaki, Mitsuko</creatorcontrib><creatorcontrib>Kondo, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Asia Pacific journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasai, Michio</au><au>Nosaka, Naohisa</au><au>Maki, Hideaki</au><au>Negishi, Satoshi</au><au>Aoyama, Toshiaki</au><au>Nakamura, Masahiro</au><au>Suzuki, Yoshie</au><au>Tsuji, Hiroaki</au><au>Uto, Harumi</au><au>Okazaki, Mitsuko</au><au>Kondo, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans</atitle><jtitle>Asia Pacific journal of clinical nutrition</jtitle><addtitle>Asia Pac J Clin Nutr</addtitle><date>2003</date><risdate>2003</risdate><volume>12</volume><issue>2</issue><spage>151</spage><epage>160</epage><pages>151-160</pages><issn>0964-7058</issn><abstract>We investigated whether a structured medium- and long-chain triacylglycerols (MLCT) diet could decrease accumulation of body fat in healthy humans. The study was conducted under a double-blind randomized design. Ninety-three subjects participated in this study. However, 10 subjects could not consume the specified meal, and one subject wished to opt out. Consequently, the study included 82 subjects. The experimental subjects consumed the test bread, which was made with 14 g of MLCT containing 1.7 g MCFA, daily at breakfast during the study period of 12 weeks, and the control subjects consumed bread made with long-chain triacylglycerols (LCT). All subjects consumed the same standard packaged meals. Body composition parameters were body weight, total body fat and abdominal fat, and blood analyses included serum cholesterol, triacylglycerols and phospholipids. Significant decreases of body weight, the amount of body fat, subcutaneous and visceral fat were noted in the MLCT group as compared with those of the LCT group for 12 weeks (P<0.05). Furthermore, a significant decrease in serum total cholesterol was noted in the MLCT group as compared with that of the LCT group at 8 weeks (P<0.05). However, other serum parameters were not different between the MLCT and LCT groups. The results suggest that the daily intake of MLCT diet could result in a reduction in body weight and in accumulation of body fat, and, moreover, it could reduce serum total cholesterol.</abstract><cop>Australia</cop><pmid>12810404</pmid><tpages>10</tpages></addata></record> |
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| subjects | Adipose Tissue - growth & development Adipose Tissue - metabolism Adult Body Composition - drug effects Body Composition - physiology Body Constitution - physiology Body Mass Index Body Weight - drug effects Cholesterol - blood Dietary Fats - administration & dosage Dietary Fats - metabolism Double-Blind Method Energy Metabolism Humans Middle Aged Obesity - diet therapy Obesity - metabolism Obesity - prevention & control Phospholipids - blood Triglycerides - administration & dosage Triglycerides - chemistry Triglycerides - metabolism Weight Loss |
| title | Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans |
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