Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice

Phosphoglycerate kinase 2 (PGK2), an isozyme that catalyzes the first ATP-generating step in the glycolytic pathway, is encoded by an autosomal retrogene that is expressed only during spermatogenesis. It replaces the ubiquitously expressed phosphoglycerate kinase 1 (PGK1) isozyme following repressio...

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Veröffentlicht in:	Biology of reproduction 2010-01, Vol.82 (1), p.136-145
Hauptverfasser:	Danshina, Polina V, Geyer, Christopher B, Dai, Qunsheng, Goulding, Eugenia H, Willis, William D, Kitto, G. Barrie, McCarrey, John R, Eddy, E.M, O'Brien, Deborah A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - metabolism Acylphosphatase Adenosine Triphosphate - metabolism Animals Biological and medical sciences Fertility Fundamental and applied biological sciences. Psychology Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Isoenzymes - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Phosphoglycerate Kinase - metabolism Sperm Count Sperm Motility Spermatogenesis Spermatozoa - enzymology Spermatozoa - ultrastructure Testis - enzymology Vertebrates: reproduction
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