Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity...

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Veröffentlicht in:Archives of pharmacal research 1997-02, Vol.20 (1), p.80-84
Hauptverfasser: Woo, N T, Jin, S Y, Cho, D J, Kim, N S, Bae, E H, Han, D, Han, B H, Kang, Y H
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container_end_page 84
container_issue 1
container_start_page 80
container_title Archives of pharmacal research
container_volume 20
creator Woo, N T
Jin, S Y
Cho, D J
Kim, N S
Bae, E H
Han, D
Han, B H
Kang, Y H
description Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.
doi_str_mv 10.1007/BF02974047
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title Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities
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