First and second order derivative spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceutical forms
Diclofenac sodium is a drug with analgesic, antipyretic and anti-inflammatory properties. It is present in numerous pharmaceutical preparations. In injectable forms, it is usually accompanied by benzyl alcohol as an excipient, which is used as a blocking anesthetic (4%) and an antiseptic (4–10%). In...
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| Veröffentlicht in: | Talanta (Oxford) 1998-11, Vol.47 (3), p.525-530 |
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| creator | de Micalizzi, Y.C Pappano, N.B Debattista, N.B |
| description | Diclofenac sodium is a drug with analgesic, antipyretic and anti-inflammatory properties. It is present in numerous pharmaceutical preparations. In injectable forms, it is usually accompanied by benzyl alcohol as an excipient, which is used as a blocking anesthetic (4%) and an antiseptic (4–10%). In this work spectrophotometric methodology was used in order to determine diclofenac and benzyl alcohol in injectable formulations by applying, on the one hand, the first-derivative method of crossing zero for diclofenac sodium and on the other, second derivative for benzyl alcohol. The results obtained show that this method has a significant advantage over other techniques and it is appropriate for routine pharmaceutical analysis. |
| doi_str_mv | 10.1016/S0039-9140(98)00080-0 |
| format | Article |
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It is present in numerous pharmaceutical preparations. In injectable forms, it is usually accompanied by benzyl alcohol as an excipient, which is used as a blocking anesthetic (4%) and an antiseptic (4–10%). In this work spectrophotometric methodology was used in order to determine diclofenac and benzyl alcohol in injectable formulations by applying, on the one hand, the first-derivative method of crossing zero for diclofenac sodium and on the other, second derivative for benzyl alcohol. 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| ispartof | Talanta (Oxford), 1998-11, Vol.47 (3), p.525-530 |
| issn | 0039-9140 1873-3573 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Analysis Biological and medical sciences General pharmacology Medical sciences Pharmacology. Drug treatments |
| title | First and second order derivative spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceutical forms |
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