Zincsulphate induced metallothionein in pancreatic islets and protected against the diabetogenic toxin streptozotocin

Zincsulphate induced metallothionein in pancreatic islets and protected against the diabetogenic toxin streptozotocin

In mice, autoimmune diabetes can be induced with multiple low doses of streptozotocin (MLD-STZ). Specific T cell-dependent immune reactions and non-specific inflammatory damage induced by reactive oxygen species (ROS) are involved in the pathogenesis of MLD-STZ diabetes. Metallothionein (MT) can be...

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Veröffentlicht in:Talanta (Oxford) 1998-06, Vol.46 (2), p.355-359
Hauptverfasser: Ohly, Patricia, Wang, Zhiyong, Abel, Josef, Gleichmann, Helga
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Medical sciences
Metallothionein
Pancreatic islets
Streptozotocin
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Zusammenfassung:In mice, autoimmune diabetes can be induced with multiple low doses of streptozotocin (MLD-STZ). Specific T cell-dependent immune reactions and non-specific inflammatory damage induced by reactive oxygen species (ROS) are involved in the pathogenesis of MLD-STZ diabetes. Metallothionein (MT) can be significantly ( P
ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(97)00347-0